Immunotronics - novel finite-state-machine architectures with built-in self-test using self-nonself differentiation

A novel approach to hardware fault tolerance is demonstrated that takes inspiration from the human immune system as a method of fault detection. The human immune system is a remarkable system of interacting cells and organs that protect the body from invasion and maintains reliable operation even in the presence of invading bacteria or viruses. This paper seeks to address the field of electronic hardware fault tolerance from an immunological perspective with the aim of showing how novel methods based upon the operation of the immune system can both complement and create new approaches to the development of fault detection mechanisms for reliable hardware systems. In particular, it is shown that by use of partial matching, as prevalent in biological systems, high fault coverage can be achieved with the added advantage of reducing memory requirements. The development of a generic finite-state-machine immunization procedure is discussed that allows any system that can be represented in such a manner to be "immunized" against the occurrence of faulty operation. This is demonstrated by the creation of an immunized decade counter that can detect the presence of faults in real tim

An overview on structural health monitoring: From the current state-of-the-art to new bio-inspired sensing paradigms

In the last decades, the field of structural health monitoring (SHM) has grown exponentially. Yet, several technical constraints persist, which are preventing full realization of its potential. To upgrade current state-of-the-art technologies, researchers have started to look at nature’s creations giving rise to a new field called ‘biomimetics’, which operates across the border between living and non-living systems. The highly optimised and time-tested performance of biological assemblies keeps on inspiring the development of bio-inspired artificial counterparts that can potentially outperform conventional systems. After a critical appraisal on the current status of SHM, this paper presents a review of selected works related to neural, cochlea and immune-inspired algorithms implemented in the field of SHM, including a brief survey of the advancements of bio-inspired sensor technology for the purpose of SHM. In parallel to this engineering progress, a more in-depth understanding of the most suitable biological patterns to be transferred into multimodal SHM systems is fundamental to foster new scientific breakthroughs. Hence, grounded in the dissection of three selected human biological systems, a framework for new bio-inspired sensing paradigms aimed at guiding the identification of tailored attributes to transplant from nature to SHM is outlined.info:eu-repo/semantics/acceptedVersio

Artificial immune systems

The biological immune system is a robust, complex, adaptive system that defends the body from foreign pathogens. It is able to categorize all cells (or molecules) within the body as self or nonself substances. It does this with the help of a distributed task force that has the intelligence to take action from a local and also a global perspective using its network of chemical messengers for communication. There are two major branches of the immune system. The innate immune system is an unchanging mechanism that detects and destroys certain invading organisms, whilst the adaptive immune system responds to previously unknown foreign cells and builds a response to them that can remain in the body over a long period of time. This remarkable information processing biological system has caught the attention of computer science in recent years

Immune System Based Control and Intelligent Agent Design for Power System Applications

The National Academy of Engineering has selected the US Electric Power Grid as the supreme engineering achievement of the 20th century. Yet, this same grid is struggling to keep up with the increasing demand for electricity, its quality and cost. A growing recognition of the need to modernize the grid to meet future challenges has found articulation in the vision of a Smart Grid in using new control strategies that are intelligent, distributed, and adaptive. The objective of this work is to develop smart control systems inspired from the biological Human Immune System to better manage the power grid at the both generation and distribution levels. The work is divided into three main sections. In the first section, we addressed the problem of Automatic Generation Control design. The Clonal Selection theory is successfully applied as an optimization technique to obtain decentralized control gains that minimize a performance index based on Area Control Errors. Then the Immune Network theory is used to design adaptive controllers in order to diminish the excess maneuvering of the units and help the control areas comply with the North American Electric Reliability Corporation\u27s standards set to insure good quality of service and equitable mutual assistance by the interconnected energy balancing areas. The second section of this work addresses the design and deployment of Multi Agent Systems on both terrestrial and shipboard power systems self-healing using a novel approach based on the Immune Multi-Agent System (IMAS). The Immune System is viewed as a highly organized and distributed Multi-Cell System that strives to heal the body by working together and communicating to get rid of the pathogens. In this work both simulation and hardware design and deployment of the MAS are addressed. The third section of this work consists in developing a small scale smart circuit by modifying and upgrading the existing Analog Power Simulator to demonstrate the effectiveness of the developed technologies. We showed how to develop smart Agents hardware along with a wireless communication platform and the electronic switches. After putting together the different designed pieces, the resulting Multi Agent System is integrated into the Power Simulator Hardware. The multi Agent System developed is tested for fault isolation, reconfiguration, and restoration problems by simulating a permanent three phase fault on one of the feeder lines. The experimental results show that the Multi Agent System hardware developed performed effectively and in a timely manner which confirms that this technology is very promising and a very good candidate for Smart Grid control applications

A machine learning pipeline for discriminant pathways identification

Motivation: Identifying the molecular pathways more prone to disruption during a pathological process is a key task in network medicine and, more in general, in systems biology. Results: In this work we propose a pipeline that couples a machine learning solution for molecular profiling with a recent network comparison method. The pipeline can identify changes occurring between specific sub-modules of networks built in a case-control biomarker study, discriminating key groups of genes whose interactions are modified by an underlying condition. The proposal is independent from the classification algorithm used. Three applications on genomewide data are presented regarding children susceptibility to air pollution and two neurodegenerative diseases: Parkinson's and Alzheimer's. Availability: Details about the software used for the experiments discussed in this paper are provided in the Appendix

Design, Development and Implementation of Intelligent Algorithms to Increase Autonomy of Quadrotor Unmanned Missions

This thesis presents the development and implementation of intelligent algorithms to increase autonomy of unmanned missions for quadrotor type UAVs. A six-degree-of freedom dynamic model of a quadrotor is developed in Matlab/Simulink in order to support the design of control algorithms previous to real-time implementation. A dynamic inversion based control architecture is developed to minimize nonlinearities and improve robustness when the system is driven outside bounds of nominal design. The design and the implementation of the control laws are described. An immunity-based architecture is introduced for monitoring quadrotor health and its capabilities for detecting abnormal conditions are successfully demonstrated through flight testing. A vision-based navigation scheme is developed to enhance the quadrotor autonomy under GPS denied environments. An optical flow sensor and a laser range finder are used within an Extended Kalman Filter for position estimation and its estimation performance is analyzed by comparing against measurements from a GPS module. Flight testing results are presented where the performances are analyzed, showing a substantial increase of controllability and tracking when the developed algorithms are used under dynamically changing environments. Healthy flights, flights with failures, flight with GPS-denied navigation and post-failure recovery are presented