3,736 research outputs found
Evidential Label Propagation Algorithm for Graphs
Community detection has attracted considerable attention crossing many areas
as it can be used for discovering the structure and features of complex
networks. With the increasing size of social networks in real world, community
detection approaches should be fast and accurate. The Label Propagation
Algorithm (LPA) is known to be one of the near-linear solutions and benefits of
easy implementation, thus it forms a good basis for efficient community
detection methods. In this paper, we extend the update rule and propagation
criterion of LPA in the framework of belief functions. A new community
detection approach, called Evidential Label Propagation (ELP), is proposed as
an enhanced version of conventional LPA. The node influence is first defined to
guide the propagation process. The plausibility is used to determine the domain
label of each node. The update order of nodes is discussed to improve the
robustness of the method. ELP algorithm will converge after the domain labels
of all the nodes become unchanged. The mass assignments are calculated finally
as memberships of nodes. The overlapping nodes and outliers can be detected
simultaneously through the proposed method. The experimental results
demonstrate the effectiveness of ELP.Comment: 19th International Conference on Information Fusion, Jul 2016,
Heidelber, Franc
A survey on utilization of data mining approaches for dermatological (skin) diseases prediction
Due to recent technology advances, large volumes of medical data is obtained. These data contain valuable information. Therefore data mining techniques can be used to extract useful patterns. This paper is intended to introduce data mining and its various techniques and a survey of the available literature on medical data mining. We emphasize mainly on the application of data mining on skin diseases. A categorization has been provided based on the different data mining techniques. The utility of the various data mining methodologies is highlighted. Generally association mining is suitable for extracting rules. It has been used especially in cancer diagnosis. Classification is a robust method in medical mining. In this paper, we have summarized the different uses of classification in dermatology. It is one of the most important methods for diagnosis of erythemato-squamous diseases. There are different methods like Neural Networks, Genetic Algorithms and fuzzy classifiaction in this topic. Clustering is a useful method in medical images mining. The purpose of clustering techniques is to find a structure for the given data by finding similarities between data according to data characteristics. Clustering has some applications in dermatology. Besides introducing different mining methods, we have investigated some challenges which exist in mining skin data
A Multiple Classifier System Identifies Novel Cannabinoid CB2 Receptor Ligands
open access articleDrugs have become an essential part of our lives due to their ability to improve people’s
health and quality of life. However, for many diseases, approved drugs are not yet available
or existing drugs have undesirable side effects, making the pharmaceutical industry strive to
discover new drugs and active compounds. The development of drugs is an expensive
process, which typically starts with the detection of candidate molecules (screening) for an
identified protein target. To this end, the use of high-performance screening techniques has
become a critical issue in order to palliate the high costs. Therefore, the popularity of
computer-based screening (often called virtual screening or in-silico screening) has rapidly
increased during the last decade. A wide variety of Machine Learning (ML) techniques has
been used in conjunction with chemical structure and physicochemical properties for
screening purposes including (i) simple classifiers, (ii) ensemble methods, and more recently
(iii) Multiple Classifier Systems (MCS). In this work, we apply an MCS for virtual screening
(D2-MCS) using circular fingerprints. We applied our technique to a dataset of cannabinoid
CB2 ligands obtained from the ChEMBL database. The HTS collection of Enamine
(1.834.362 compounds), was virtually screened to identify 48.432 potential active molecules
using D2-MCS. This list was subsequently clustered based on circular fingerprints and from
each cluster, the most active compound was maintained. From these, the top 60 were kept,
and 21 novel compounds were purchased. Experimental validation confirmed six highly
active hits (>50% displacement at 10 ÎĽM and subsequent Ki determination) and an
additional five medium active hits (>25% displacement at 10 ÎĽM). D2-MCS hence provided a
hit rate of 29% for highly active compounds and an overall hit rate of 52%
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