Convergencia de tecnologías ópticas y Ethernet en LAN, MAN y SAN: nuevas arquitecturas, análisis de prestaciones y eficiencia energética

Mención Internacional en el título de doctorThe development of Information Technologies in the last decades, especially the last two, together with the introduction of computing devices to the mainstream consumer market, has had the logical consequence of the generalisation of the Internet access. The explosive development of the smartphone market has brought ubiquity to that generalisation, to the point that social interaction, content sharing and content production happens all the time. Social networks have all but increased that trend, maximising the diffusion of multimedia content: images, audio and video, which require high network capacities to be enjoyed quickly. This need for endless bandwidth and speed in information sharing brings challenges that affect mainly optical Metropolitan Area Networks (MANs) and Wide Area Networks (WANs). Furthermore, the wide spreading of Ethernet technologies has also brought the possibility to achieve economies of scale by either extending the reach of Ethernet Local Area Networks (LANs) to the MAN and WAN environment or even integrating them with Storage Area Networks (SANs). Finally, this generalisation of telecommunication technologies in every day life has as a consequence an important rise in energy consumption as well. Because of this, providing energy efficient strategies in networking is key to ensure the scalability of the whole Internet. In this thesis, the main technologies in all the fields mentioned above are reviewed, its core challenges identified and several contributions beyond the state of the art are suggested to improve today’s MANs andWANs. In the first contribution of this thesism, the integration between Metro Ethernet and Wavelength Division Multiplexion (WDM) optical transparent rings is explored by proposing an adaptation architecture to provide efficient broadcast and multicast. The second contribution explores the fusion between transparent WDM and OCDMA architectures to simplify medium access in a ring. Regarding SANs, the third contribution explores the challenges in SANs through the problems of Fibre Channel over Ethernet due to buffer design issues. In this contribution, analysis, design and validation with FCoE traces and simulation is provided to calculate buffer overflow probabilities in the absence of flow control mechanisms taking into account the bursty nature of SAN traffic. Finally, the fourth and last contribution addresses the problems of energy efficiency in Plastic Optical Fibres (POF), a new kind of optical fibre more suitable for transmission in vehicles and for home networking. This contribution suggests two packet coalescing strategies to further improve the energy effiency mechanisms in POFs.El desarrollo de las Tecnologías de la Información en las últimas décadas, especialmente las últimas dos, junto con la introducción de dispositivos informáticos al mercado de masas, ha tenido como consecuencia lógica la generalización del acceso a Internet. El explosivo desarrollo del mercado de teléfonos inteligentes ha añadido un factor de ubicuidad a tal generalización, al extremo de que la interacción social, la compartición y producción de contenidos sucede a cada instante. Las redes sociales no han hecho sino incrementar tal tendencia, maximizando la difusión de contenido multimedia: imágenes, audio y vídeo, los cuales requieren gran capacidad en las redes para poder obtenerse con rapidez. Esta necesidad de ancho de banda ilimitado y velocidad en la compartición de información trae consigo retos que afectan principalmente a las Redes de Área Metropolitana (Metropolitan Area Networks, MANs) y Redes de Área Extensa (Wide Area Networks, WANs). Además, la gran difusión de las tecnologías Ethernet ha traído la posibilidad de alcanzar economías de escala bien extendiendo el alcance de Ethernet más allá de las Redes de Área Local (Local Area Networks, LANs) al entorno de las MAN y las WAN o incluso integrándolas con Redes de Almacenamiento (Storage Area Networks, SANs). Finalmente, esta generalización de las tecnologías de la comunicación en la vida cotidiana tiene también como consecuencia un importante aumento en el consumo de energía. Por tanto, desarrollar estrategias de transmisión en red eficientes energéticamente es clave para asegurar la escalabilidad de Internet. En esta tesis, las principales tecnologías de todos los campos mencionados arriba serán estudiadas, sus más importantes retos identificados y se sugieren varias contribuciones más allá del actual estado del arte para mejorar las actuales MANs y WANs. En la primera contribución de esta tesis, se explora la integración entre Metro Ethernet y anillos ópticos transparentes por Multiplexión en Longitud de Onda (Wavelength Division Multiplex, WDM) mediante la proposición de una arquitectura de adaptación para permitir la difusión y multidifusión eficiente. La segunda contribución explora la fusión entre las arquitecturas transparentes WDM y arquitecturas por Accesso Dividido Múltiple por Códigos Ópticos (OCDMA) para simplificar el acceso en una red en anillo. En lo referente a las SANs, la tercera contribución explora los retos en SANs a través de los problemas de Fibre Channel sobre Ethernet debido a los problemas en el diseño de búferes. En esta contribución, se provee un análisis, diseño y validación con trazas FCoE para calcular las probabilidades de desbordamiento de buffer en ausencia de mecanismos de control de flujo teniendo en cuenta la naturaleza rafagosa del tráfico de SAN. Finalmente, la cuarta y última contribución aborda los problemas de eficiencia energética en Fibras Ópticas Plásticas (POF), una nueva variedad de fibra óptica más adecuada para la transmisión en vehículos y para entornos de red caseros. Esta contribución sugiere dos estrategias de agrupamiento de paquetes para mejorar los mecanismos de eficiencia energética en POFs.Programa Oficial de Posgrado en Ingeniería TelemáticaPresidente: Luca Valcarenghi.- Secretario: Ignacio Soto Campos.- Vocal: Bas Huiszoo

Gamma-ray Bursts: 15 Years of GRB Afterglows

Gamma-ray bursts (GRB) are amongst the most energetic phenomena in the Universe. In 1997 (more than 15 years ago), BeppoSAX allowed the detection of the first GRB X-ray afterglow, leading to the detection of afterglows at other wavelengths (optical, radio) in the following years, probing the cosmological distance scale. There are still many other open issues which still need to be addressed, regarding both theoretical and observational aspects: prompt emission and afterglow physics, progenitors (including Pop III stars), host galaxies, multi-messenger information, etc

Dichotomic role of NAADP/two-pore channel 2/Ca2+ signaling in regulating neural differentiation of mouse embryonic stem cells

Poster Presentation - Stem Cells and Pluripotency: abstract no. 1866The mobilization of intracellular Ca2+stores is involved in diverse cellular functions, including cell proliferation and differentiation. At least three endogenous Ca2+mobilizing messengers have been identified, including inositol trisphosphate (IP3), cyclic adenosine diphosphoribose (cADPR), and nicotinic adenine acid dinucleotide phosphate (NAADP). Similar to IP3, NAADP can mobilize calcium release in a wide variety of cell types and species, from plants to animals. Moreover, it has been previously shown that NAADP but not IP3-mediated Ca2+increases can potently induce neuronal differentiation in PC12 cells. Recently, two pore channels (TPCs) have been identified as a novel family of NAADP-gated calcium release channels in endolysosome. Therefore, it is of great interest to examine the role of TPC2 in the neural differentiation of mouse ES cells. We found that the expression of TPC2 is markedly decreased during the initial ES cell entry into neural progenitors, and the levels of TPC2 gradually rebound during the late stages of neurogenesis. Correspondingly, perturbing the NAADP signaling by TPC2 knockdown accelerates mouse ES cell differentiation into neural progenitors but inhibits these neural progenitors from committing to the final neural lineage. Interestingly, TPC2 knockdown has no effect on the differentiation of astrocytes and oligodendrocytes of mouse ES cells. Overexpression of TPC2, on the other hand, inhibits mouse ES cell from entering the neural lineage. Taken together, our data indicate that the NAADP/TPC2-mediated Ca2+signaling pathway plays a temporal and dichotomic role in modulating the neural lineage entry of ES cells; in that NAADP signaling antagonizes ES cell entry to early neural progenitors, but promotes late neural differentiation.postprin