Environmental Audit improvements in industrial systems through FRAM

Environmental risk management requires specific methodologies to focus audit activities on the most critical elements of production systems. Limited resources require a clear motivation to put attention on specific technological, human, organizational components, and often should address the monitor of interactions among these elements. Recent research in environmental risk looks at methods to deal with complexity as interesting tools to reduce real impacts on pollution and consumption. In this paper, we provide evidence of the advantage in using the Functional Resonance Analysis Method (FRAM), not only to identify the criticalities of a complex production system but to provide a methodology to continuously improve the audit activities in parallel with the introduction of technique to reduce environmental risk. The case study presents the evolution of environmental audit in a sinter plant, proving the need for a review of the criticality list and the successful application of FRAM to refocus the control activities

Timing models for high-level synthesis

In this paper, we describe a timing model for clock estimation during high-level synthesis. In order to obtain realistic timing estimates, the proposed model considers all delay elements, including datapath, control and wire delays, and several technology factors, such as layout architecture, technology mapping, buffers insertion and loading effects. The experimental results show that this model can provide much better estimates than previous models. This model is well suited for automatic and interactive synthesis as well as feedback-driven synthesis where performance matrices must be rapidly and incrementally calculated

A Product Line Systems Engineering Process for Variability Identification and Reduction

Software Product Line Engineering has attracted attention in the last two decades due to its promising capabilities to reduce costs and time to market through reuse of requirements and components. In practice, developing system level product lines in a large-scale company is not an easy task as there may be thousands of variants and multiple disciplines involved. The manual reuse of legacy system models at domain engineering to build reusable system libraries and configurations of variants to derive target products can be infeasible. To tackle this challenge, a Product Line Systems Engineering process is proposed. Specifically, the process extends research in the System Orthogonal Variability Model to support hierarchical variability modeling with formal definitions; utilizes Systems Engineering concepts and legacy system models to build the hierarchy for the variability model and to identify essential relations between variants; and finally, analyzes the identified relations to reduce the number of variation points. The process, which is automated by computational algorithms, is demonstrated through an illustrative example on generalized Rolls-Royce aircraft engine control systems. To evaluate the effectiveness of the process in the reduction of variation points, it is further applied to case studies in different engineering domains at different levels of complexity. Subject to system model availability, reduction of 14% to 40% in the number of variation points are demonstrated in the case studies.Comment: 12 pages, 6 figures, 2 tables; submitted to the IEEE Systems Journal on 3rd June 201

Treatment algorithm for infants diagnosed with spinal muscular atrophy through newborn screening

Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by the degeneration of alpha motor neurons in the spinal cord, leading to muscular atrophy. SMA is caused by deletions or mutations in the survival motor neuron 1 gene (SMN1). In humans, a nearly identical copy gene, SMN2, is present. Because SMN2 has been shown to decrease disease severity in a dose-dependent manner, SMN2 copy number is predictive of disease severity. To develop a treatment algorithm for SMA-positive infants identified through newborn screening based upon SMN2 copy number. A working group comprised of 15 SMA experts participated in a modified Delphi process, moderated by a neutral third-party expert, to develop treatment guidelines. The overarching recommendation is that all infants with two or three copies of SMN2 should receive immediate treatment (n = 13). For those infants in which immediate treatment is not recommended, guidelines were developed that outline the timing and appropriate screens and tests to be used to determine the timing of treatment initiation. The identification SMA affected infants via newborn screening presents an unprecedented opportunity for achievement of maximal therapeutic benefit through the administration of treatment pre-symptomatically. The recommendations provided here are intended to help formulate treatment guidelines for infants who test positive during the newborn screening process

From FPGA to ASIC: A RISC-V processor experience

This work document a correct design flow using these tools in the Lagarto RISC- V Processor and the RTL design considerations that must be taken into account, to move from a design for FPGA to design for ASIC