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Design for Additive Manufacturing: A Method to Explore Unexplored Regions of the Design Space
Additive Manufacturing (AM) technologies enable the fabrication of parts and devices that
are geometrically complex, have graded material compositions, and can be customized. To take
advantage of these capabilities, it is important to assist designers in exploring unexplored regions
of design spaces. We present a Design for Additive Manufacturing (DFAM) method that
encompasses conceptual design, process selection, later design stages, and design for
manufacturing. The method is based on the process-structure-property-behavior model that is
common in the materials design literature. A prototype CAD system is presented that embodies
the method. Manufacturable ELements (MELs) are proposed as an intermediate representation
for supporting the manufacturing related aspects of the method. Examples of cellular materials
are used to illustrate the DFAM method.Mechanical Engineerin
The latent process decomposition of cDNA microarray data sets
We present a new computational technique (a software implementation, data sets, and supplementary information are available at http://www.enm.bris.ac.uk/lpd/) which enables the probabilistic analysis of cDNA microarray data and we demonstrate its effectiveness in identifying features of biomedical importance. A hierarchical Bayesian model, called latent process decomposition (LPD), is introduced in which each sample in the data set is represented as a combinatorial mixture over a finite set of latent processes, which are expected to correspond to biological processes. Parameters in the model are estimated using efficient variational methods. This type of probabilistic model is most appropriate for the interpretation of measurement data generated by cDNA microarray technology. For determining informative substructure in such data sets, the proposed model has several important advantages over the standard use of dendrograms. First, the ability to objectively assess the optimal number of sample clusters. Second, the ability to represent samples and gene expression levels using a common set of latent variables (dendrograms cluster samples and gene expression values separately which amounts to two distinct reduced space representations). Third, in contrast to standard cluster models, observations are not assigned to a single cluster and, thus, for example, gene expression levels are modeled via combinations of the latent processes identified by the algorithm. We show this new method compares favorably with alternative cluster analysis methods. To illustrate its potential, we apply the proposed technique to several microarray data sets for cancer. For these data sets it successfully decomposes the data into known subtypes and indicates possible further taxonomic subdivision in addition to highlighting, in a wholly unsupervised manner, the importance of certain genes which are known to be medically significant. To illustrate its wider applicability, we also illustrate its performance on a microarray data set for yeast
Index to NASA Tech Briefs, 1975
This index contains abstracts and four indexes--subject, personal author, originating Center, and Tech Brief number--for 1975 Tech Briefs
Plasma Nanoscience: from Nano-Solids in Plasmas to Nano-Plasmas in Solids
The unique plasma-specific features and physical phenomena in the
organization of nanoscale solid-state systems in a broad range of elemental
composition, structure, and dimensionality are critically reviewed. These
effects lead to the possibility to localize and control energy and matter at
nanoscales and to produce self-organized nano-solids with highly unusual and
superior properties. A unifying conceptual framework based on the control of
production, transport, and self-organization of precursor species is introduced
and a variety of plasma-specific non-equilibrium and kinetics-driven phenomena
across the many temporal and spatial scales is explained. When the plasma is
localized to micrometer and nanometer dimensions, new emergent phenomena arise.
The examples range from semiconducting quantum dots and nanowires, chirality
control of single-walled carbon nanotubes, ultra-fine manipulation of
graphenes, nano-diamond, and organic matter, to nano-plasma effects and
nano-plasmas of different states of matter.Comment: This is an essential interdisciplinary reference which can be used by
both advanced and early career researchers as well as in undergraduate
teaching and postgraduate research trainin
Ono: an open platform for social robotics
In recent times, the focal point of research in robotics has shifted from industrial ro- bots toward robots that interact with humans in an intuitive and safe manner. This evolution has resulted in the subfield of social robotics, which pertains to robots that function in a human environment and that can communicate with humans in an int- uitive way, e.g. with facial expressions. Social robots have the potential to impact many different aspects of our lives, but one particularly promising application is the use of robots in therapy, such as the treatment of children with autism. Unfortunately, many of the existing social robots are neither suited for practical use in therapy nor for large scale studies, mainly because they are expensive, one-of-a-kind robots that are hard to modify to suit a specific need. We created Ono, a social robotics platform, to tackle these issues. Ono is composed entirely from off-the-shelf components and cheap materials, and can be built at a local FabLab at the fraction of the cost of other robots. Ono is also entirely open source and the modular design further encourages modification and reuse of parts of the platform
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