Nano-Bio Hybrid Electronic Sensors for Chemical Detection and Disease Diagnostics

The need to detect low concentrations of chemical or biological targets is ubiquitous in environmental monitoring and biomedical applications. The goal of this work was to address challenges in this arena by combining nanomaterials grown via scalable techniques with chemical receptors optimized for the detection problem at hand. Advances were made in the CVD growth of graphene, carbon nanotubes and molybdenum disulfide. Field effect transistors using these materials as the channel were fabricated using methods designed to avoid contamination of the nanomaterial surfaces. These devices were used to read out electronic signatures of binding events of molecular targets in both vapor and solution phases. Single-stranded DNA functionalized graphene and carbon nanotubes were shown to be versatile receptors for a wide variety of volatile molecular targets, with characteristic responses that depended on the DNA sequence and the identity of the target molecule, observable down to part-per-billion concentrations. This technology was applied to increasingly difficult detection challenges, culminating in a study of blood plasma samples from patients with ovarian cancer. By working with large arrays of devices and studying the devices\u27 responses to pooled plasma samples and plasma samples from 24 individuals, sufficient data was collected to identify statistically robust patterns that allow samples to be classified as coming from individuals who are healthy or have either benign or malignant ovarian tumors. Solution-phase detection experiments focused on the design of surface linkers and specific receptors for medically relevant molecular targets. A non-covalent linker was used to attach a known glucose receptor to carbon nanotubes and the resulting hybrid was shown to be sensitive to glucose at the low concentrations found in saliva, opening up a potential pathway to glucose monitoring without the need for drawing blood. In separate experiments, molybdenum disulfide transistors were functionalized with a re-engineered variant of a μ-opiod receptor, a cell membrane protein that binds opiods and regulates pain and reward signaling in the body. The resulting devices were shown to bind opiods with affinities that agree with measurements in the native state. This result could enable not only an advanced opiod sensor but moreover could be generalized into a solid-state drug testing platform, allowing the interactions of novel pharmaceuticals and their target proteins to be read out electronically. Such a system could have high throughput due to the quick measurement, scalable device fabrication and high sensitivity of the molybdenum disulfide transistor

A thin monocrystalline diaphragm pressure sensor using silicon-on-insulator technology.

The sensors market is huge and growing annually, of this a large sector is pressure sensors. With increasing demands on performance there remains a need for ultraminiature, high performance pressure sensors, particularly for medicai applications. To address this a novel capacitive pressure sensor consisting of an array of parallel connected diaphragms has been designed and fabricated from SIMOX substrates. The benefits of this include single crystal silicon diaphragms, small, well controlled dimensions, single sided processing and the opportunity for electronics integration. Theoretical modelling of this structure predicts a high sensitivity and low stress device with opportunities for scaling to suit alternative applications. A novel, process technology was developed to achieve the required structure with the inclusion of procedures to address the specific issues relating to the SIMOX material. The sensor was fully characterised and the results demonstrated high performance compared with similar reported devices. Alternative structures such as cantilevers, bridges and resonators were fabricated as a demonstrative tool to show the feasibility of this technology in a wider field of applications

Production and application of textile materials

This specialized publication is dedicated to technical and technological solutions in textile production. Engineering solutions in the production of fibers and fabrics for both technical and domestic use are considered. Particular attention in the book is given to the study of textile products for biomedical applications. Modern medical fabrics and fibers are used as dressing and suture material and significantly accelerate the recovery processes after surgical operations and burn injuries. Fibers and fabrics are currently often used as a reinforcing element in the production of various composite materials, which are often used in mechanical engineering and in the construction sector. A separate chapter is devoted to textile reinforcing materials. Environmental problems in textile production are mainly related to the dyeing process and the chemical treatment of fabrics and fibers. Some aspects of textile dyeing and wastewater treatment processes are also discussed in this publication. The book will be useful to specialists involved in textile production and related industries

National Educators' Workshop: Update 1993. Standard Experiments in Engineering Materials Science and Technology

This document contains a collection of experiments presented and demonstrated at the National Educators' Workshop: Update 93 held at the NASA Langley Research Center in Hampton, Virginia, on November 3-5, 1993. The experiments related to the nature and properties of engineering materials and provided information to assist in teaching about materials in the education community

MC 2019 Berlin Microscopy Conference - Abstracts

Das Dokument enthält die Kurzfassungen der Beiträge aller Teilnehmer an der Mikroskopiekonferenz "MC 2019", die vom 01. bis 05.09.2019, in Berlin stattfand

Best available techniques (BAT) reference document on surface treatment using organic solvents including preservation of wood and wood products with chemicals: Industrial Emissions Directive 2010/75/EU (Integrated Pollution Prevention and Control)

The Best Available Techniques (BAT) Reference Document (BREF) on Surface Treatment using Organic Solvents including Preservation of Wood and Wood Products with Chemicals is part of a series of documents presenting the results of an exchange of information between EU Member States, the industries concerned, non-governmental organisations promoting environmental protection, and the Commission, to draw up, review and – where necessary – update BAT reference documents as required by Article 13(1) of Directive 2010/75/EU on Industrial Emissions (the Directive). This document is published by the European Commission pursuant to Article 13(6) of the Directive. The BREF on Surface Treatment Using Organic Solvents including Preservation of Wood and Wood Products with Chemicals covers the surface treatment of substances, objects or products using organic solvents as well as the preservation of wood and wood products using chemicals as specified in Sections 6.7 and 6.10 of Annex I to Directive 2010/75/EU respectively. Important issues for the implementation of Directive 2010/75/EU in the surface treatment using organic solvents (STS) and the wood preservation with chemicals (WPC) sectors are emissions to air and water as well as energy and water consumption. Chapter 1 provides general information on the STS sector and on the main environmental issues associated with their use. Chapters 2 to 14 give the applied processes, current emission and consumption levels, techniques to consider in the determination of BAT for the STS sectors that are covered by these chapters. Chapter 15 provides general information, applied processes, current emission and consumption levels, techniques to consider in the determination of BAT for the wood preservation sector. Chapter 16 provides thumbnail descriptions of additional STS sectors, for which a data collection via questionnaires has not been carried out. General techniques to consider in the determination of BAT (i.e. those techniques to consider that are widely applied in the STS sector) are reported in Chapter 17. Chapter 18 presents the BAT conclusions as defined in Article 3(12) of the Directive, both general and sector-specific. Chapter 19 provides the emerging techniques for the STS and WPC sectors. Concluding remarks and recommendations for future work are presented in Chapter 20.JRC.B.5-Circular Economy and Industrial Leadershi

Bowdoin Orient v.131, no.1-24 (1999-2000)

https://digitalcommons.bowdoin.edu/bowdoinorient-2000s/1000/thumbnail.jp