An Implantable Low Pressure, Low Drift, Dual BioPressure Sensor and In-Vivo Calibration Methods Thereof

The human body’s intracranial pressure (ICP) is a critical component in sustaining healthy blood flow to the brain while allowing adequate volume for brain tissue within the rigid structures of the cranium. Disruptions in the body’s autoregulation of intracranial pressure are often caused by hemorrhage, tumors, edema, or excess cerebral spinal fluid resulting in treatments that are estimated to globally cost up to approximately five billion dollars annually. A critical element in the contemporary management of acute head injury, intracranial hemorrhage, stroke, or other conditions resulting in intracranial hypertension, is the real-time monitoring of ICP. Currently, such mainstream clinical monitoring can only take place short-term within an acute care hospital. The monitoring is prone to measurement drift and is comprised of externally tethered pressure sensors that are temporarily implanted into the brain, thus carrying a significant risk of infection. To date, reliable, low drift, completely internalized, long-term ICP monitoring devices remain elusive. The successful development of such a device would not only be safer and more reliable in the short-term but would expand the use of ICP monitoring for the management of chronic intracranial hypertension and enable further clinical research into these disorders. The research herein reviews the current challenges of existing ICP monitoring systems, develops a new novel sensing technology, and evaluates the same for potentially facilitating long-term implantable ICP sensing. Based upon the findings of this research, this dissertation proposes and evaluates a dual matched-die piezo-resistive strain sensing device, with a novel in-vivo calibration system and method thereof, for application to long-term implantable ICP sensing

VihreäIT metriikoiden analysointi sekä mittausviitekehyksen luonti Sonera Helsinki Datakeskus (HDC) projektille.

The two objectives of this thesis were to investigate and evaluate the most suitable set of energy efficiency metrics for Sonera Helsinki Data Center (HDC), and to analyze which energy efficient technologies could be implemented and in what order to gain most impact. Sustainable IT is a complex matter, and it has two components. First and the more complex matter is the energy efficiency and energy-proportionality of the IT environment. The second is the use of renewable energy sources. Both of these need to be addressed. This thesis is a theoretical study, and it focuses on energy efficiency. The use of off-site renewables is outside of the scope of this thesis. The main aim of this thesis is to improve energy efficiency through effective metric framework. In the final metric framework, metrics that target renewable energy usage in the data center are included as they are important from CO2 emission reduction perspective. The selection of energy efficient solutions in this thesis are examples from most important data center technology categories, and do not try to cover the whole array of different solutions to improve energy efficiency in a data center. The ontological goal is to present main energy efficiency metrics available in scientific discourse, and also present examples of energy efficient solutions in most energy consuming technology domains inside the data center. Even though some of the concepts are quite abstract, realism is taken into account in every analysis. The epistemology in this thesis is based on scientific articles that include empirical validation and scientific peer review. This forms the origin of the used knowledge and the nature of this knowledge. The findings from this thesis are considered valid and reliable based on the epistemology of scientific articles, and by using the actual planning documents of Sonera HDC. The reasoning in this thesis is done in abstracto, but there are many empirical results that qualify the results also as ´in concreto´. Findings are significant for Sonera HDC but they are also applicable for any general data center project or company seeking energy efficiency in their data centers.Lopputyöllä on kaksi päätavoitetta. Ensimmäinen tavoite on löytää sopivin mittausviitekehys energiatehokkuuden osoittamiseksi Sonera Helsinki Datakeskukselle (HDC). Toisena tavoitteena on analysoida, mitä energiatehokkaita ratkaisuja tulisi implementoida ja missä järjestyksessä, saavuttaakseen mahdollisimman ison vaikutuksen. Vihreä IT on monimutkainen asia ja samalla siihen liittyy kaksi eri komponenttia. Ensimmäisenä komponenttina, ja merkityksellisempänä sekä monimutkaisempana, on energiatehokkuus ja energian kulutuksen mukautuvuus suhteessa työkuormaan. Toinen komponentti vihreän IT:n osalta on uusiutuvien energialähteiden käyttäminen. Molemmat komponentit on huomioitava. Lopputyö on teoreettinen tutkimus. Lopputyön ontologinen tavoite on esittää keskeisimmät energiatehokkuusmittarit, jotka ovat saatavilla tieteellisessä keskustelussa, ja esittää myös esimerkkejä energiatehokkaista ratkaisuista teknologia-alueisiin, jotka kuluttavat eniten energiaa data keskuksissa. Vaikka osa esitetyistä ratkaisuista on melko abstraktissa todellisuudessa, realismi on pyritty ottamaan huomioon arvioita tehdessä. Epistemologisesti tämä lopputyö perustuu tieteellisiin artikkeleihin, joissa on tehty empiiristä validointia ja tiedeyhteisön vertaisarviointia tiedon totuusarvosta. Kirjoittaja pyrkii välttämään oman arvomaailman ja subjektiivisen näkemyksen tuomista analyysiin pyrkimällä enemmänkin arvioimaan ratkaisuja perustuen päätavoitteeseen, joka on sekä lisätä energiatehokkuutta että vähentää CO2 -päästöjä datakeskuksessa. Lopputyön löydökset todetaan valideiksi ja luotettaviksi, koska ne perustuvat tieteellisten artikkeleiden epistemologiaan ja siihen, että arvioinnin pohjana on käytetty todellisia Sonera HDC -projektin suunnitteludokumentteja. Päätelmät ja analyysit ovat abstrahoituja, mutta perustuvat empiirisiin tuloksiin, jotka koskevat käytännön tekemistä sekä valintoja. Löydökset ovat merkittäviä Sonera HDC -projektin kannalta, ja myös muille datakeskuksille, jotka haluavat toimia kestävän kehityksen pohjalta

HE-LHC: The High-Energy Large Hadron Collider – Future Circular Collider Conceptual Design Report Volume 4

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries

High-Luminosity Large Hadron Collider (HL-LHC): Technical Design Report

The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 9000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its instantaneous luminosity (rate of collisions) by a factor of five beyond the original design value and the integrated luminosity (total number of collisions) by a factor ten. The LHC is already a highly complex and exquisitely optimised machine so this upgrade must be carefully conceived and will require new infrastructures (underground and on surface) and over a decade to implement. The new configuration, known as High Luminosity LHC (HL-LHC), relies on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11–12 Tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 100 metre-long high-power superconducting links with negligible energy dissipation, all of which required several years of dedicated R&D effort on a global international level. The present document describes the technologies and components that will be used to realise the project and is intended to serve as the basis for the detailed engineering design of the HL-LHC