6,751 research outputs found
Multi-objective Optimization of Biochemical System Production Using an Improve Newton Competitive Differential Evolution Method
In this paper, an improve method of multi-objective optimization for biochemical system production is presented and discussed in detail. The optimization process of biochemical system production become hard and difficult when involved a large biochemical system that contain with many components. In addition, the multi-objective problem also need to be considered. Due to that, this study proposed and improve method that comprises with Newton method, differential evolution algorithm (DE) and competitive co-evolutionary algorithm(ComCA). The aim of the proposed method is to maximize the production and simultaneously minimize the total amount of chemical concentrations involves. The operation of the proposed method starts with Newton method by dealing with biochemical system production as a nonlinear equations system. Then DE and ComCA are used to represent the variables in nonlinear equation system and tune the variables in order to find the best solution. The used of DE is to maximize the production while ComCA is to minimize the total amount of chemical concentrations involves. The effectiveness of the proposed method is evaluated using two benchmark biochemical systems and the experimental results show that the proposed method perform well compared to other works
Exploiting network topology for large-scale inference of nonlinear reaction models
The development of chemical reaction models aids understanding and prediction
in areas ranging from biology to electrochemistry and combustion. A systematic
approach to building reaction network models uses observational data not only
to estimate unknown parameters, but also to learn model structure. Bayesian
inference provides a natural approach to this data-driven construction of
models. Yet traditional Bayesian model inference methodologies that numerically
evaluate the evidence for each model are often infeasible for nonlinear
reaction network inference, as the number of plausible models can be
combinatorially large. Alternative approaches based on model-space sampling can
enable large-scale network inference, but their realization presents many
challenges. In this paper, we present new computational methods that make
large-scale nonlinear network inference tractable. First, we exploit the
topology of networks describing potential interactions among chemical species
to design improved "between-model" proposals for reversible-jump Markov chain
Monte Carlo. Second, we introduce a sensitivity-based determination of move
types which, when combined with network-aware proposals, yields significant
additional gains in sampling performance. These algorithms are demonstrated on
inference problems drawn from systems biology, with nonlinear differential
equation models of species interactions
Biological Networks
Networks of coordinated interactions among biological entities govern a myriad of biological functions that span a wide range of both length and time scales—from ecosystems to individual cells and from years to milliseconds. For these networks, the concept “the whole is greater than the sum of its parts” applies as a norm rather than an exception. Meanwhile, continued advances in molecular biology and high-throughput technology have enabled a broad and systematic interrogation of whole-cell networks, allowing the investigation of biological processes and functions at unprecedented breadth and resolution—even down to the single-cell level. The explosion of biological data, especially molecular-level intracellular data, necessitates new paradigms for unraveling the complexity of biological networks and for understanding how biological functions emerge from such networks. These paradigms introduce new challenges related to the analysis of networks in which quantitative approaches such as machine learning and mathematical modeling play an indispensable role. The Special Issue on “Biological Networks” showcases advances in the development and application of in silico network modeling and analysis of biological systems
- …