617 research outputs found
Long-term vascular access ports as a means of sedative administration in a rodent fMRI survival model
The purpose of this study is to develop a rodent functional magnetic resonance imaging (fMRI) survival model with the use of heparin-coated vascular access devices. Such a model would ease the administration of sedative agents, reduce the number of animals required in survival experiments and eliminate animal-to-animal variability seen in previous designs. Seven male Sprague-Dawley rats underwent surgical placement of an MRI-compatible vascular access port, followed by implantable electrode placement on the right median nerve. Functional MRI during nerve stimulation and resting-state functional connectivity MRI (fcMRI) were performed at times 0, 2, 4, 8 and 12 weeks postoperatively using a 9.4 T scanner. Anesthesia was maintained using intravenous dexmedetomidine and reversed using atipamezole. There were no fatalities or infectious complications during this study. All vascular access ports remained patent. Blood oxygen level dependent (BOLD) activation by electrical stimulation of the median nerve using implanted electrodes was seen within the forelimb sensory region (S1FL) for all animals at all time points. The number of activated voxels decreased at time points 4 and 8 weeks, returning to a normal level at 12 weeks, which is attributed to scar tissue formation and resolution around the embedded electrode. The applications of this experiment extend far beyond the scope of peripheral nerve experimentation. These vascular access ports can be applied to any survival MRI study requiring repeated medication administration, intravenous contrast, or blood sampling
A Monte Carlo platform for the optical modeling of pulse oximetry
We investigated a custom Monte Carlo (MC) platform in the generation of opto-physiological models of motion artefact
and perfusion in pulse oximetry. With the growing availability and accuracy of tissue optical properties in literatures,
MC simulation of light-tissue interaction is providing increasingly valuable information for optical bio-monitoring
research. Motion-induced artefact and loss of signal quality during low perfusion are currently the primary limitations in
pulse oximetry. While most attempts to circumvent these issues have focused on signal post-processing techniques, we
propose the development of improved opto-physiological models to include the characterisation of motion artefact and
low perfusion. In this stage of the research, a custom MC platform is being developed for its use in determining the
effects of perfusion, haemodynamics and tissue-probe optical coupling on transillumination at different positions of the
human finger. The results of MC simulations indicate a useful and predictable output from the platform
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A Pulsatile Optical Tissue Phantom for the Investigation of Light-Tissue Interaction in Reflectance Photoplethysmography
The aim of this study was to investigate the effect of emitter-detector separation distance and arterial depth in reflectance photoplethysmography (PPG), utilizing a homogenous pulsatile phantom that exhibits the broad optical absorbance and scattering properties of human tissue. The developed phantom comprised of embedded silicone arteries (outer diameter = 4 mm) that were arranged parallel to one another at nine increasing depths (3.2 mm to 24.4 mm). A pulsatile pump (Harvard Apparatus, MA, USA) circulated a blood imitating fluid through the vessels at the desired heart rate (60 bpm) and stroke volume (5 Lmin-1). The PPG sensor’s emitter and detector were isolated on a translation bridge to provide a computer-controlled separation distance between them. Recordings were taken at each vessel depth for emitter-detector separation distances from 2 mm to 8 mm in 0.1 mm steps. The optimum separation distance between the emitter and detector for vessels between depths of 3.2 mm and 10.5 mm was between 3.7 and 4.3 mm, suggesting that the maximum penetration of IR (930 nm) light in a homogenous pulsatile phantom is no greater than 10.5 mm
Evidence to support magnetic resonance conditional labelling of all pacemaker and defibrillator leads in patients with cardiac implantable electronic devices
Aims:
Many cardiac pacemakers and defibrillators are not approved by regulators for magnetic resonance imaging (MRI). Even following generator exchange to an approved magnetic resonance (MR)-conditional model, many systems remain classified ‘non-MR conditional’ due to the leads. This classification makes patient access to MRI challenging, but there is no evidence of increased clinical risk. We compared the effect of MRI on non-MR conditional and MR-conditional pacemaker and defibrillator leads. //
Methods and results:
Patients undergoing clinical 1.5T MRI with pacemakers and defibrillators in three centres over 5 years were included. Magnetic resonance imaging protocols were similar for MR-conditional and non-MR conditional systems. Devices were interrogated pre- and immediately post-scan, and at follow-up, and adverse clinical events recorded. Lead parameter changes peri-scan were stratified by MR-conditional labelling. A total of 1148 MRI examinations were performed in 970 patients (54% non-MR conditional systems, 39% defibrillators, 15% pacing-dependent) with 2268 leads. There were no lead-related adverse clinical events, and no clinically significant immediate or late lead parameter changes following MRI in either MR-conditional or non-MR conditional leads. Small reductions in atrial and right ventricular sensed amplitudes and impedances were similar between groups, with no difference in the proportion of leads with parameter changes greater than pre-defined thresholds (7.1%, 95% confidence interval: 6.1–8.3). //
Conclusions:
There was no increased risk of MRI in patients with non-MR conditional pacemaker or defibrillator leads when following recommended protocols. Standardizing MR conditions for all leads would significantly improve access to MRI by enabling patients to be scanned in non-specialist centres, with no discernible incremental risk
Preporuke za postupanje kod bolesnika sa srčanim implantabilnim elektroničkim uređajima koji su podvrgnuti magnetskoj rezonanci - Radna skupina za aritmije i elektrostimulaciju Hrvatskoga kardiološkog društva
For many years, magnetic resonance imaging (MRI) was contraindicated in patients with cardiac implantable electronic devices (CIED). Today, there is a growing amount of evidence that MRI can be performed safely in the majority of patients with CIEDs. Firstly, there are devices considered MRI conditional by manufacturers that are available on the market and secondly, there is clear evidence that even patients with MRI non-conditional devices can also undergo MRI safely. Protocols have been developed and recommendations from different cardiac and radiologic societies have been published in recent years. However, the majority of physicians are still reluctant to refer these patients to MRI. Therefore, this document is published as a joint statement of the Croatian Working Group on Arrhythmias and Cardiac Pacing and Department of Radiology, Sestre milosrdnice University Hospital Centre to guide and ease the management of patients with CIED undergoing
MRI. Also, we propose a unified protocol and checklist that could be used in Croatian hospitals.Magnetska rezonanca (MR) dugo je bila kontraindicirana dijagnostička metoda kod bolesnika sa srčanim implantabilnim elektroničkim uređajima (CIED). Danas imamo dovoljno dokaza da se MR može sigurno učiniti kod većine bolesnika s CIED. Prvo, postoje uređaji koji mogu biti podvrgnuti MR prema preporukama proizvođača, a drugo, postoje jasni dokazi da većina uređaja koji nisu označeni kao sigurni za MR od proizvođača također mogu biti podvrgnuti MR. Tijekom godina
razvijeni su brojni protokoli kardioloških i radioloških društava, međutim, dio liječnika i dalje oklijeva kod postavljanja indikacije
za MR u ove skupine bolesnika. Stoga je Radna skupina za aritmije i elektrostimulaciju srca Hrvatskoga kardiološkog društva u suradnji s radiolozima KBC Sestre milosrdnice pripremila preporuke za postupanje s bolesnicima s CIED koji su podvrgnuti MR
Miniaturized Piezo Force Sensor for a Medical Catheter and Implantable Device
Real-time monitoring of intrabody pressures can benefit from the use of miniaturized force sensors during surgical interventions or for the recovery period thereafter. Herein, we present a force sensor made of poly(vinylidene fluoride)-co-trifluoroethylene (P(VDF-TrFE)) with a simple fabrication process that has been integrated into the tip of a medical catheter for intraluminal pressure monitoring, as well as into an implantable device with a power consumption of 180 μW obtained by the near-field communication (NFC) interface to monitor the arterial pulse at the subcutaneous level (≤1 cm). The pressure range supported by the sensor is below 40 kPa, with a signal responsivity of 0.63 μV/Pa and a mean lifetime expectancy of 400 000 loading cycles inside physiological conditions (12 kPa). The proposed sensor has been tested experimentally with synthetic anatomical models for the lungs (bronchoscopy) and subcutaneous tissue, as well as directly above the human carotid and radial arteries. Information about these pressure levels can provide insights about tissue homeostasis inside the body as fluid dynamics are altered in some health conditions affecting the hemodynamic and endocrine body systems, whereas for surgical interventions, precise control and estimation of the pressure exerted by a catheter over the internal walls are necessary to avoid endothelium injuries that lead to bleeding, liquid extravasation, or flow alteration associated with atheroma formation
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