Peaks detection and alignment for mass spectrometry data

The goal of this paper is to review existing methods for protein mass spectrometry data analysis, and to present a new methodology for automatic extraction of significant peaks (biomarkers). For the pre-processing step required for data from MALDI-TOF or SELDI- TOF spectra, we use a purely nonparametric approach that combines stationary invariant wavelet transform for noise removal and penalized spline quantile regression for baseline correction. We further present a multi-scale spectra alignment technique that is based on identification of statistically significant peaks from a set of spectra. This method allows one to find common peaks in a set of spectra that can subsequently be mapped to individual proteins. This may serve as useful biomarkers in medical applications, or as individual features for further multidimensional statistical analysis. MALDI-TOF spectra obtained from serum samples are used throughout the paper to illustrate the methodology

A FPGA system for QRS complex detection based on Integer Wavelet Transform

Due to complexity of their mathematical computation, many QRS detectors are implemented in software and cannot operate in real time. The paper presents a real-time hardware based solution for this task. To filter ECG signal and to extract QRS complex it employs the Integer Wavelet Transform. The system includes several components and is incorporated in a single FPGA chip what makes it suitable for direct embedding in medical instruments or wearable health care devices. It has sufficient accuracy (about 95%), showing remarkable noise immunity and low cost. Additionally, each system component is composed of several identical blocks/cells what makes the design highly generic. The capacity of today existing FPGAs allows even dozens of detectors to be placed in a single chip. After the theoretical introduction of wavelets and the review of their application in QRS detection, it will be shown how some basic wavelets can be optimized for easy hardware implementation. For this purpose the migration to the integer arithmetic and additional simplifications in calculations has to be done. Further, the system architecture will be presented with the demonstrations in both, software simulation and real testing. At the end, the working performances and preliminary results will be outlined and discussed. The same principle can be applied with other signals where the hardware implementation of wavelet transform can be of benefit

Active Vision With Multiresolution Wavelets

A wavelet decomposition for multiscale edge detection is used to separate border edges from texture in an image, toward the goal of a complete segmentation by Active Perception for robotic exploration of a scene. The physical limitations of the image acquisition system and the robotic system provide the limitations on the range of scales which we consider. We link edges through scale space, using the characteristics of these wavelets for guidance. The linked zero crossings are used to remove texture and preserve borders, then the scene can be reconstructed without texture

Dyadic Wavelets Energy Zero-Crossings

An important problem in signal analysis is to define a general purpose signal representation which is well adapted for developing pattern recognition algorithms. In this paper we will show that such a representation can be defined from the position of the zero-crossings and the local energy values of a dyadic wavelet decomposition. This representation is experimentally complete and admits a simple distance for pattern matching applications. It provides a multiscale decomposition of the signal and at each scale characterizes the locations of abrupt changes in the signal. We have developed a stereo matching algorithm to illustrate the application of this representation to pattern matching