Low-Dose CT Using Denoising Diffusion Probabilistic Model for 20×\times Speedup

Low-dose computed tomography (LDCT) is an important topic in the field of radiology over the past decades. LDCT reduces ionizing radiation-induced patient health risks but it also results in a low signal-to-noise ratio (SNR) and a potential compromise in the diagnostic performance. In this paper, to improve the LDCT denoising performance, we introduce the conditional denoising diffusion probabilistic model (DDPM) and show encouraging results with a high computational efficiency. Specifically, given the high sampling cost of the original DDPM model, we adapt the fast ordinary differential equation (ODE) solver for a much-improved sampling efficiency. The experiments show that the accelerated DDPM can achieve 20x speedup without compromising image quality

Adaptive Edge-guided Block-matching and 3D filtering (BM3D) Image Denoising Algorithm

Image denoising is a well studied field, yet reducing noise from images is still a valid challenge. Recently proposed Block-matching and 3D filtering (BM3D) is the current state of the art algorithm for denoising images corrupted by Additive White Gaussian noise (AWGN). Though BM3D outperforms all existing methods for AWGN denoising, still its performance decreases as the noise level increases in images, since it is harder to find proper match for reference blocks in the presence of highly corrupted pixel values. It also blurs sharp edges and textures. To overcome these problems we proposed an edge guided BM3D with selective pixel restoration. For higher noise levels it is possible to detect noisy pixels form its neighborhoods gray level statistics. We exploited this property to reduce noise as much as possible by applying a pre-filter. We also introduced an edge guided pixel restoration process in the hard-thresholding step of BM3D to restore the sharpness of edges and textures. Experimental results confirm that our proposed method is competitive and outperforms the state of the art BM3D in all considered subjective and objective quality measurements, particularly in preserving edges, textures and image contrast

Low-Dose CT Image Denoising using Image Decomposition and Sparse Representation

X-ray computed tomography (CT) is now a widely used imaging modality for numerous medical purposes. The risk of high X-ray radiation may induce genetic, cancerous and other diseases, demanding the development of new image processing methods that are able to enhance the quality of low-dose CT images. However, lowering the radiation dose increases the noise in acquired images and hence affects important diagnostic information. This paper contributes an efficient denoising method for low-dose CT images. A noisy image is decomposed into three component images of low, medium and high frequency bands; noise is mainly presented in the medium and high component images. Then, by exploiting the fact that a small image patch of the noisy image can be approximated by a linear combination of several elements in a given dictionary of noise-free image patches generated from noise-free images taken at nearly the same position with the noisy image, noise in these medium and high component images are effectively eliminated.Specifically, we give new solutions for image decomposition to easily control the filter parameters, for dictionary construction to improve the effectiveness and reduce the running-time. Instead of using a large dataset of patches, only a structured small part of patches extracted from the raw data is used to form a dictionary, to be used in sparse coding. In addition, we illustrate the effectiveness of the proposed method in preserving image details which are subtle but clinically important. Experimental results conducted on both synthetic and real noise data demonstrate that the proposed method is competitive with the state-of-the-art methods

Region based 4D tomographic image reconstruction: Application to cardiac x-ray CT

X-ray computed tomography (CT) is a powerful tool for noninvasive cardiac imaging. However, radiation dose is a major issue. In this paper, we propose an iterative reconstruction method that reduces the radiation dose without compromising image quality. This is achieved by exploiting prior knowledge in two ways: the reconstructed object is assumed to consist of both stationary and dynamic regions over time and the dynamic region is assumed to have sparse structures after a proper sparsifying space-time transform. Experiments on simulation data and a real micro-CT cardiac mouse dataset show that, with comparable image quality, the radiation dose can be substantially reduced compared to conventional acquisition/reconstruction protocols