Italian center for Astronomical Archives publishing solution: modular and distributed

The Italian center for Astronomical Archives tries to provide astronomical data resources as interoperable services based on IVOA standards. Its VO expertise and knowledge comes from active participation within IVOA and VO at European and international level, with a double-fold goal: learn from the collaboration and provide inputs to the community. The first solution to build an easy to configure and maintain resource publisher conformant to VO standards proved to be too optimistic. For this reason it has been necessary to re-think the architecture with a modular system built around the messaging concept, where each modular component speaks to the other interested parties through a system of broker-managed queues. The first implemented protocol, the Simple Cone Search, shows the messaging task architecture connecting the parametric HTTP interface to the database backend access module, the logging module, and allows multiple cone search resources to be managed together through a configuration manager module. Even if relatively young, it already proved the flexibility required by the overall system when the database backend changed from MySQL to PostgreSQL+PgSphere. Another implementation test has been made to leverage task distribution over multiple servers to serve simultaneously: FITS cubes direct linking, cubes cutout and cubes positional merging. Currently the implementation of the SIA-2.0 standard protocol is ongoing while for TAP we will be adapting the TAPlib library. Alongside these tools a first administration tool (TASMAN) has been developed to ease the build up and maintenance of TAP_SCHEMA-ta including also ObsCore maintenance capability. Future work will be devoted at widening the range of VO protocols covered by the set of available modules, improve the configuration management and develop specific purpose modules common to all the service components.Comment: SPIE Astronomical Telescopes + Instrumentation 2018, Software and Cyberinfrastructure for Astronomy V, pre-publishing draft proceeding (reduced abstract

Mapping and Displaying Structural Transformations between XML and PDF

Documents are often marked up in XML-based tagsets to delineate major structural components such as headings, paragraphs, figure captions and so on, without much regard to their eventual displayed appearance. And yet these same abstract documents, after many transformations and 'typesetting' processes, often emerge in the popular format of Adobe PDF, either for dissemination or archiving. Until recently PDF has been a totally display-based document representation, relying on the underlying PostScript semantics of PDF. Early versions of PDF had no mechanism for retaining any form of abstract document structure but recent releases have now introduced an internal structure tree to create the so called 'Tagged PDF'. This paper describes the development of a plugin for Adobe Acrobat which creates a two-window display. In one window is shown an XML document original and in the other its Tagged PDF counterpart is seen, with an internal structure tree that, in some sense, matches the one seen in XML. If a component is highlighted in either window then the corresponding structured item, with any attendant text, is also highlighted in the other window. Important applications of correctly Tagged PDF include making PDF documents reflow intelligently on small screen devices and enabling them to be read out in correct reading order, via speech synthesiser software, for the visually impaired. By tracing structure transformation from source document to destination one can implement the repair of damaged PDF structure or the adaptation of an existing structure tree to an incrementally updated document

Design and validation of a medical robotic device system to control two collaborative robots for ultrasound-guided needle insertions

The percutaneous biopsy is a critical intervention for diagnosis and staging in cancer therapy. Robotic systems can improve the efficiency and outcome of such procedures while alleviating stress for physicians and patients. However, the high complexity of operation and the limited possibilities for robotic integration in the operating room (OR) decrease user acceptance and the number of deployed robots. Collaborative systems and standardized device communication may provide approaches to overcome named problems. Derived from the IEEE 11073 SDC standard terminology of medical device systems, we designed and validated a medical robotic device system (MERODES) to access and control a collaborative setup of two KUKA robots for ultrasound-guided needle insertions. The system is based on a novel standard for service-oriented device connectivity and utilizes collaborative principles to enhance user experience. Implementing separated workflow applications allows for a flexible system setup and configuration. The system was validated in three separate test scenarios to measure accuracies for 1) co-registration, 2) needle target planning in a water bath and 3) in an abdominal phantom. The co-registration accuracy averaged 0.94 ± 0.42 mm. The positioning errors ranged from 0.86 ± 0.42 to 1.19 ± 0.70 mm in the water bath setup and from 1.69 ± 0.92 to 1.96 ± 0.86 mm in the phantom. The presented results serve as a proof-of-concept and add to the current state of the art to alleviate system deployment and fast configuration for percutaneous robotic interventions

Real-time Observation of Dynamic Sarcomeric Addition in an In Vivo-like Cardiomyocyte Culture Model

Cardiac hypertrophy is the enlargement of individual cardiac muscle cell (cardiomyocyte) in both size and mass, which is achieved by addition of sarcomeres, the basic contractile unit. Cardiomyocytes elongate by adding sarcomeres in series and thicken by adding sarcomeres in parallel. Though it is generally accepted that sarcomeric addition can be initiated by increased mechanical loading, the sarcomeric addition process under various mechanical overloads on molecular level remains largely unknown. Previous research on sarcomeric addition largely rely on animal models of induced cardiac hypertrophy; those experiments provide little direct evidence for sarcomeric addition process as a response to increased mechanical loading, aside from the start and end point conditions. Studies showing the dynamic addition process of sarcomeric addition are rare, due to lack of in vivo-like cardiomyocyte culture models for mechanical assays and limited choice of live imaging techniques. In this project, a 3D cardiomyocyte culture model that recapitulates the in vivo-like mechanical loading environment, was established in vitro on a 2D PDMS substrate. With this culture model, we, for the first time, revealed the dynamic sarcomeric addition process at intercalated discs and Z discs with custom-built passive pulse splitter-based TPEF-SHG microscope, which confirmed the long-standing hypothesis of sarcomeric addition at intercalated discs and Z discs. These findings may advance the comprehension of cardiomyocyte remodeling process on sarcomeric level during development of cardiac hypertrophy