31,300 research outputs found
Friendship and Natural Selection
More than any other species, humans form social ties to individuals who are
neither kin nor mates, and these ties tend to be with similar people. Here, we
show that this similarity extends to genotypes. Across the whole genome,
friends' genotypes at the SNP level tend to be positively correlated
(homophilic); however, certain genotypes are negatively correlated
(heterophilic). A focused gene set analysis suggests that some of the overall
correlation can be explained by specific systems; for example, an olfactory
gene set is homophilic and an immune system gene set is heterophilic. Finally,
homophilic genotypes exhibit significantly higher measures of positive
selection, suggesting that, on average, they may yield a synergistic fitness
advantage that has been helping to drive recent human evolution
Transcriptome-wide analysis reveals different categories of response to a standardised immune challenge in a wild rodent
Individuals vary in their immune response and, as a result, some are more susceptible to infectious disease than others. Little is known about the nature of this individual variation in natural populations, or which components of immune pathways are most responsible, but defining this underlying landscape of variation is an essential first step to understanding the drivers of this variation and, ultimately, predicting the outcome of infection. We describe transcriptome-wide variation in response to a standardised immune challenge in wild field voles. We find that markers can be categorised into a limited number of types. For the majority of markers, the response of an individual is dependent on its baseline expression level, with significant enrichment in this category for conventional immune pathways. Another, moderately sized, category contains markers for which the responses of different individuals are also variable but independent of their baseline expression levels. This category lacks any enrichment for conventional immune pathways. We further identify markers which display particularly high individual variability in response, and could be used as markers of immune response in larger studies. Our work shows how a standardised challenge performed on a natural population can reveal the patterns of natural variation in immune response
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