Model-based analysis of increased loads on the performance of activated sludge and waste stabilization ponds

In a way to counter criticism on low cost-effective conventional activated sludge (AS) technology, waste stabilization ponds (WSPs) offer a valid alternative for wastewater treatment due to their simple and inexpensive operation. To evaluate this alternative with respect to its robustness and resilience capacity, we perform in silico experiments of different peak-load scenarios in two mathematical models representing the two systems. A systematic process of quality assurance for these virtual experiments is implemented, including sensitivity and identifiability analysis, with non-linear error propagation. Moreover, model calibration of a 210-day real experiment with 31 days of increased load was added to the evaluation. Generally speaking, increased-load scenarios run in silico showed that WSP systems are more resilient towards intermediate disturbances, hence, are suitable to treat not only municipal wastewater, but also industrial wastewater, such as poultry wastewater, and paperboard wastewater. However, when disturbances are extreme (over 7000 mg COD.L-1), the common design of the natural system fails to perform better than AS. Besides, the application of sensitivity analysis reveals the most influential parameters on the performance of the two systems. In the AS system, parameters related to autotrophic bacteria have the highest influence on the dynamics of particulate organic matter, while nitrogen removal is largely driven by nitrification and denitrification. Conversely, with an insignificant contribution of heterotrophs, the nutrient removal in the pond system is mostly done by algal assimilation. Furthermore, this systematic model-based analysis proved to be a suitable means for investigating the maximum load of wastewater treatment systems, and from that avoiding environmental problems and high economic costs for cleaning surface waters after severe overload events

Municipal wastewater treatment with pond technology : historical review and future outlook

Facing an unprecedented population growth, it is difficult to overstress the assets for wastewater treatment of waste stabilization ponds (WSPs), i.e. high removal efficiency, simplicity, and low cost, which have been recognized by numerous scientists and operators. However, stricter discharge standards, changes in wastewater compounds, high emissions of greenhouse gases, and elevated land prices have led to their replacements in many places. This review aims at delivering a comprehensive overview of the historical development and current state of WSPs, and providing further insights to deal with their limitations in the future. The 21st century is witnessing changes in the way of approaching conventional problems in pond technology, in which WSPs should no longer be considered as a low treatment technology. Advanced models and technologies have been integrated for better design, control, and management. The roles of algae, which have been crucial as solar-powered aeration, will continue being a key solution. Yet, the separation of suspended algae to avoid deterioration of the effluent remains a major challenge in WSPs while in the case of high algal rate pond, further research is needed to maximize algal growth yield, select proper strains, and optimize harvesting methods to put algal biomass production in practice. Significant gaps need to be filled in understanding mechanisms of greenhouse gas emission, climate change mitigation, pond ecosystem services, and the fate and toxicity of emerging contaminants. From these insights, adaptation strategies are developed to deal with new opportunities and future challenges

Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats

The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in cats

Greenhouse gas emissions from wastewater treatment plants on a plantwide scale: Sensitivity and uncertainty analysis

This paper presents the sensitivity and uncertainty analysis of a mathematical model for greenhouse gas emission (GHG) and energy consumption assessment in wastewater treatment plants. A sensitivity analysis was carried out (using two different methods) to determine which model factors have the greatest effect on the predicted values of the GHG production. Further, an uncertainty analysis was carried out to quantify the uncertainty of the key model outputs, such as carbon dioxide production from activated sludge treatment. The results show that influent fractionation factors, which characterize influent composition, have an important role on direct and indirect GHGs production and emission. Moreover, model factors related to the aerobic biomass growth show a relevant influence on GHGs in terms of emission from off-site power generation (mCO2eq,PG). Further, model factors related to the autotrophic biomass growth were found to strongly interact with other factors especially in modeling mCO2eq,PG. Finally, nitrous oxide (N2O) emission associated with the effluent has the highest uncertainty, suggesting the need for a mechanistic model for N2O production in biological treatment