3,411 research outputs found

    The Recent History of Platelets in Thrombosis and Other Disorders

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    The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 25 November 2003. Introduction by Professor Tom Meade, London School of Hygiene and Tropical Medicine.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2005. ©The Trustee of the Wellcome Trust, London, 2005. All volumes freely available following the links to publications and Wellcome Witnesses at www.ucl.ac.uk/histmed.Annotated and edited transcript of a Witness Seminar held on 25 November 2003. Introduction by Professor Tom Meade, London School of Hygiene and Tropical Medicine.Annotated and edited transcript of a Witness Seminar held on 25 November 2003. Introduction by Professor Tom Meade, London School of Hygiene and Tropical Medicine.Annotated and edited transcript of a Witness Seminar held on 25 November 2003. Introduction by Professor Tom Meade, London School of Hygiene and Tropical Medicine.Annotated and edited transcript of a Witness Seminar held on 25 November 2003. Introduction by Professor Tom Meade, London School of Hygiene and Tropical Medicine.Annotated and edited transcript of a Witness Seminar held on 25 November 2003. Introduction by Professor Tom Meade, London School of Hygiene and Tropical Medicine.Annotated and edited transcript of a Witness Seminar held on 25 November 2003. Introduction by Professor Tom Meade, London School of Hygiene and Tropical Medicine.The recent history of research on platelets and its applications in medicine started with the introduction of ex vivo methods for studying platelet behaviour. The Witness Seminar held on 25 November 2003, chaired by Professor Tom Meade, considered the detailed study of platelets starting with the recognition of their role in haemostasis, both in thrombotic and bleeding disorders . Professor Gustav Born described his research and the invention and development of the optical aggregometer that bears his name. Other topics included the biochemistry and function of platelets ; the platelet release reaction and the effect of aspirin on it ; the Nobel Prize-winning discovery by Sir John Vane of how aspirin inhibits the natural production of prostaglandins; and results of randomized controlled trials of aspirin and other thrombolytic drugs for the prevention of thrombotic conditions. An appendix includes a discussion of the streptokinase trials, 1986-96, from the unpublished Witness Seminar meeting on Thrombolysis held on 28 January 2003, chaired by Professor Brian Pentecost. Participants : Dr Y S [Mick] Bakhle, Sir Christopher Booth, Professor Donald Chambers, Professor John Dickinson, Professor Peter Elwood, Professor Rod Flower, Professor Alison Goodall, Professor John Hampton, Professor Michael Harrison, Professor Stan Heptinstall, Dr Peter Hunter, Dr Peter MacCallum, Dr Marty Mahaut-Smith, Professor Salvador Moncada, Professor Michael Oliver, Professor Clive Page, Professor Sir Stanley Peart, Professor Colin Prentice, Professor Peter Richardson, Dr Stewart Sage, and Dr Duncan Thomas; and from Thrombolysis, Dr Hewan Dewar, the late Sir Richard Doll, Professor John Hampton, Dr Arthur Hollman, Professor Desmond Julian, Dr Robin Norris, Professor Tom Quinn, Dr Roger Smith, and Professor Andrew Stevens. Reynolds L A, Tansey E M. (eds) (2005) The Recent history of platelets in thrombosis and other disorders, Wellcome Witnesses to Twentieth Century Medicine, vol. 23. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust,which is a registered charity, no. 210183

    JRC annual report 1997. EUR 18097

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    Evaluation of MF and UF as pretreatments prior to RO applied to reclaim waste water for fresh water substituion in a paper mill: A practical experience

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    A pilot plant study has been carried out to compare the effectiveness of different low pressure membrane systems (microfiltration and ultrafiltration) as pretreatments for a reverse osmosis system producing high quality reclaimed water from the effluent of a municipal wastewater treatment plant receiving a high percentage of industrial wastewater. The reclaimed water will be used to substitute fresh water in a paper mill. Although the implemented systems showed several problems derived from the unstable quality of the feed water, they were solid enough to keep a constant permeate quality; i.e. percentages of salt rejection above 99%, efficiencies in the removal of microorganisms to lower values than 1 CFU/100 mL, and final COD results below the detection limit (<5 mg L−1). In short, the quality of the produced reclaimed water was good enough to be used substituting fresh water in a paper mill. An enhanced monitoring of the quality of the water feeding the municipal wastewater treatment plant and an improved corresponding management of the treatments performed in there may be one of the keys to the success of this type of reclamation initiatives. Achieving constant disinfection, an appropriate design of the plants, and a good performance of cleaning operations were very important factors to be considered in order to fight against fouling. Temperature and the soaking time of chemical membrane cleanings were particularly well-optimized for the success of the treatment. Chloramines were compared to free chlorine as disinfection agent achieving satisfactory results

    JRC annual report 1997. EUR 18097

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    Algorithmic Jim Crow

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    This Article contends that current immigration- and security-related vetting protocols risk promulgating an algorithmically driven form of Jim Crow. Under the “separate but equal” discrimination of a historic Jim Crow regime, state laws required mandatory separation and discrimination on the front end, while purportedly establishing equality on the back end. In contrast, an Algorithmic Jim Crow regime allows for “equal but separate” discrimination. Under Algorithmic Jim Crow, equal vetting and database screening of all citizens and noncitizens will make it appear that fairness and equality principles are preserved on the front end. Algorithmic Jim Crow, however, will enable discrimination on the back end in the form of designing, interpreting, and acting upon vetting and screening systems in ways that result in a disparate impact

    Women's economic advancement through agricultural change

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    This paper reviews donor experience with the design of development projects that are sensitive to gender-specific constraints. The review finds that the gap between intentions and implementation as regards gender-sensitivity is larger in agriculture than in health and nutrition. One of the reasons forwarded for this gap is the dearth of quantitative studies documenting the foregone benefits in terms of agricultural productivity of not promoting the economic advancement of women in agriculture.employment ,Nutrition ,Gender ,Women Economic conditions. ,Women Employment Bangladesh. ,Women in agriculture Bangladesh. ,Gender. ,Nutrition ,

    Hide and seek between Andromeda's halo, disk, and giant stream

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    Photometry in B, V (down to V ~ 26 mag) is presented for two 23' x 23' fields of the Andromeda galaxy (M31) that were observed with the blue channel camera of the Large Binocular Telescope during the Science Demonstration Time. Each field covers an area of about 5.1kpc x 5.1kpc at the distance of M31 ((m-M)o ~ 24.4 mag), sampling, respectively, a northeast region close to the M31 giant stream (field S2), and an eastern portion of the halo in the direction of the galaxy minor axis (field H1). The stream field spans a region that includes Andromeda's disk and the giant stream, and this is reflected in the complexity of the color magnitude diagram of the field. One corner of the halo field also includes a portion of the giant stream. Even though these demonstration time data were obtained under non-optimal observing conditions the B photometry, acquired in time-series mode, allowed us to identify 274 variable stars (among which 96 are bona fide and 31 are candidate RR Lyrae stars, 71 are Cepheids, and 16 are binary systems) by applying the image subtraction technique to selected portions of the observed fields. Differential flux light curves were obtained for the vast majority of these variables. Our sample includes mainly pulsating stars which populate the instability strip from the Classical Cepheids down to the RR Lyrae stars, thus tracing the different stellar generations in these regions of M31 down to the horizontal branch of the oldest (t ~ 10 Gyr) component.Comment: 59 pages, 26 figures, 12 tables, ApJ in pres

    A study of defibrillator waveforms, vectors, and therapies Kevin Anthony Michael.

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    Includes abstract.Includes bibliographical references.The defibrillation studies were performed in a porcine model given its resemblance to the human heart and its resilience to repeated ventricular fibrillation inductions (VF) and defibrillations. A novel sequential preshock waveform was assessed in a prototype serial capacitance device. Single and multi-electrode defibrillation vectors were evaluated in intra-cardiac, subcutaneous (SQ), and intra-pericardial configurations. The burden of ITS and the factors improving detection were assessed. Anti-tachycardia pacing was used to evaluate therapies in this patient cohort. The diagnostic utility of the post pacing interval (PPI) after failed ATP episodes was then investigated to help discriminate between atrial fibrillation/tachycardia (AF/AT) and VT
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