Design, Fabrication, and Testing of an Electrospinning Apparatus for the Deposition of PMMA Polymer for Biomedical Applications

This paper describes the successful design and fabrication of a deposition system for synthesis and assembly of nanoscale and submicron sized fibers of poly(methylmethacrylate)(PMMA) polymer. To optimize the electrospinning deposition process, the distance between the needle and the electrically grounded substrate, the applied voltage, and the concentration of PMMA polymer in the solution were varied. PMMA fibers as small as 500 nanometers were observed using scanning electron microscopy (SEM). The chemical signature of PMMA was confirmed for best quality and retention of chemistry using Fourier Transformed Infrared spectroscopy (FT-IR). PMMA is a biocompatible polymer, and nanofibers of PMMA are key building blocks for scaffolds and other biomanufacturing applications, such as bioprinting for regenerative medicine and tissue engineering of synthetic organs (Mo, 2004)

Report on the Information Retrieval Festival (IRFest2017)

The Information Retrieval Festival took place in April 2017 in Glasgow. The focus of the workshop was to bring together IR researchers from the various Scottish universities and beyond in order to facilitate more awareness, increased interaction and reflection on the status of the field and its future. The program included an industry session, research talks, demos and posters as well as two keynotes. The first keynote was delivered by Prof. Jaana Kekalenien, who provided a historical, critical reflection of realism in Interactive Information Retrieval Experimentation, while the second keynote was delivered by Prof. Maarten de Rijke, who argued for more Artificial Intelligence usage in IR solutions and deployments. The workshop was followed by a "Tour de Scotland" where delegates were taken from Glasgow to Aberdeen for the European Conference in Information Retrieval (ECIR 2017

Microheated substrates for patterning cells and controlling development

Here, we seek to control cellular development by devising a means through which cells can be subjected to a microheated environment in standard culture conditions. Numerous techniques have been devised for controlling cellular function and development via manipulation of surface environmental cues at the micro- and nanoscale. It is well understood that temperature plays a significant role in the rate of cellular activities, migratory behavior (thermotaxis), and in some cases, protein expression. Yet, the effects and possible utilization of micrometer-scale temperature fields in cell cultures have not been explored. Toward this end, two types of thermally isolated microheated substrates were designed and fabricated, one with standard backside etching beneath a dielectric film and another with a combination of surface and bulk micromachining and backside etching. The substrates were characterized with infrared microscopy, finite element modeling, scanning electron microscopy, stylus profilometry, and electrothermal calibrations. Neuron culture studies were conducted on these substrates to 1) examine the feasibility of using a microheated environment to achieve patterned cell growth and 2) selectively accelerate neural development on regions less than 100$mu m$wide. Results show that attached neurons, grown on microheated regions set at 37$~^circ C$, extended processes substantially faster than those incubated at 25$~^circ C$on the same substrate. Further, unattached neurons were positioned precisely along the length of the heater filament (operating at 45$~^circ C$) using free convection currents. These preliminary findings indicate that microheated substrates may be used to direct cellular development spatially in a practical manner.$hfillhbox[1414]

Coordinating tasks in M-form and U-form organisations

We model the coordination of specialised tasks inside an organisation as "attribute matching". Using this method, we compare the performance of organisational forms (M-form and U-form) in implementing changes such as innovation and reform. In our framework, organisational forms affect the information structure of an organisation and thus the way to coordinate changes. Compared to the U-form, the M-form organisation achieves better coordination but suffers from fewer economies of scale. The distinctive advantage of the M-form is flexibility of experimentation, which allows the organisation to introduce more innovation and reform. The theory is illustrated by the organisational differences between China and the former Soviet Union and sheds light on their different reform strategies, particularly with regard to the prevalence of the experimental approach in China

We Don't Need Another Hero? The Impact of "Heroes" on Software Development

A software project has "Hero Developers" when 80% of contributions are delivered by 20% of the developers. Are such heroes a good idea? Are too many heroes bad for software quality? Is it better to have more/less heroes for different kinds of projects? To answer these questions, we studied 661 open source projects from Public open source software (OSS) Github and 171 projects from an Enterprise Github. We find that hero projects are very common. In fact, as projects grow in size, nearly all project become hero projects. These findings motivated us to look more closely at the effects of heroes on software development. Analysis shows that the frequency to close issues and bugs are not significantly affected by the presence of project type (Public or Enterprise). Similarly, the time needed to resolve an issue/bug/enhancement is not affected by heroes or project type. This is a surprising result since, before looking at the data, we expected that increasing heroes on a project will slow down howfast that project reacts to change. However, we do find a statistically significant association between heroes, project types, and enhancement resolution rates. Heroes do not affect enhancement resolution rates in Public projects. However, in Enterprise projects, the more heroes increase the rate at which project complete enhancements. In summary, our empirical results call for a revision of a long-held truism in software engineering. Software heroes are far more common and valuable than suggested by the literature, particularly for medium to large Enterprise developments. Organizations should reflect on better ways to find and retain more of these heroesComment: 8 pages + 1 references, Accepted to International conference on Software Engineering - Software Engineering in Practice, 201

Generic parameters governing the biofunctionality of laser surface engineered nylon 6,6

On account of an ever increasing demand on medicine there is a need and a drive by the biomedical industry to develop robust and predictable implant technology. This paper gives an account of the implementation of CO2 and KrF excimer laser systems to modulate the biofunctionality of nylon 6,6 in terms of osteoblast cell response. There were correlative trends between the cell response, contact angle, polar component and surface oxygen content for the whole area irradiative processed samples. Thus, allowing one to identify the potential for this technology in regenerative medicine. However, no strong correlations were determined for the laser-induced patterned samples which can be attributed to the likely mixed-state wetting regime. Through analytical analysis, governing equations are discussed, showing how different parameters can be used to predict the wettability of, and biological cell response to, laser surface engineered nylon 6,6

Malicious cryptography techniques for unreversable (malicious or not) binaries

Fighting against computer malware require a mandatory step of reverse engineering. As soon as the code has been disassemblied/decompiled (including a dynamic analysis step), there is a hope to understand what the malware actually does and to implement a detection mean. This also applies to protection of software whenever one wishes to analyze them. In this paper, we show how to amour code in such a way that reserse engineering techniques (static and dymanic) are absolutely impossible by combining malicious cryptography techniques developped in our laboratory and new types of programming (k-ary codes). Suitable encryption algorithms combined with new cryptanalytic approaches to ease the protection of (malicious or not) binaries, enable to provide both total code armouring and large scale polymorphic features at the same time. A simple 400 Kb of executable code enables to produce a binary code and around $2^{140}$ mutated forms natively while going far beyond the old concept of decryptor.Comment: 17 pages, 2 figures, accepted for presentation at H2HC'1

Local search: A guide for the information retrieval practitioner

There are a number of combinatorial optimisation problems in information retrieval in which the use of local search methods are worthwhile. The purpose of this paper is to show how local search can be used to solve some well known tasks in information retrieval (IR), how previous research in the field is piecemeal, bereft of a structure and methodologically flawed, and to suggest more rigorous ways of applying local search methods to solve IR problems. We provide a query based taxonomy for analysing the use of local search in IR tasks and an overview of issues such as fitness functions, statistical significance and test collections when conducting experiments on combinatorial optimisation problems. The paper gives a guide on the pitfalls and problems for IR practitioners who wish to use local search to solve their research issues, and gives practical advice on the use of such methods. The query based taxonomy is a novel structure which can be used by the IR practitioner in order to examine the use of local search in IR

Computational Contributions to the Automation of Agriculture

The purpose of this paper is to explore ways that computational advancements have enabled the complete automation of agriculture from start to finish. With a major need for agricultural advancements because of food and water shortages, some farmers have begun creating their own solutions to these problems. Primarily explored in this paper, however, are current research topics in the automation of agriculture. Digital agriculture is surveyed, focusing on ways that data collection can be beneficial. Additionally, self-driving technology is explored with emphasis on farming applications. Machine vision technology is also detailed, with specific application to weed management and harvesting of crops. Finally, the effects of automating agriculture are briefly considered, including labor, the environment, and direct effects on farmers