ERP evidence suggests executive dysfunction in ecstasy polydrug users

Background: Deficits in executive functions such as access to semantic/long-term memory have been shown in ecstasy users in previous research. Equally, there have been many reports of equivocal findings in this area. The current study sought to further investigate behavioural and electro-physiological measures of this executive function in ecstasy users. Method: Twenty ecstasy–polydrug users, 20 non-ecstasy–polydrug users and 20 drug-naïve controls were recruited. Participants completed background questionnaires about their drug use, sleep quality, fluid intelligence and mood state. Each individual also completed a semantic retrieval task whilst 64 channel Electroencephalography (EEG) measures were recorded. Results: Analysis of Variance (ANOVA) revealed no between-group differences in behavioural performance on the task. Mixed ANOVA on event-related potential (ERP) components P2, N2 and P3 revealed significant between-group differences in the N2 component. Subsequent exploratory univariate ANOVAs on the N2 component revealed marginally significant between-group differences, generally showing greater negativity at occipito-parietal electrodes in ecstasy users compared to drug-naïve controls. Despite absence of behavioural differences, differences in N2 magnitude are evidence of abnormal executive functioning in ecstasy–polydrug users

Transmit Optimization with Improper Gaussian Signaling for Interference Channels

This paper studies the achievable rates of Gaussian interference channels with additive white Gaussian noise (AWGN), when improper or circularly asymmetric complex Gaussian signaling is applied. For the Gaussian multiple-input multiple-output interference channel (MIMO-IC) with the interference treated as Gaussian noise, we show that the user's achievable rate can be expressed as a summation of the rate achievable by the conventional proper or circularly symmetric complex Gaussian signaling in terms of the users' transmit covariance matrices, and an additional term, which is a function of both the users' transmit covariance and pseudo-covariance matrices. The additional degrees of freedom in the pseudo-covariance matrix, which is conventionally set to be zero for the case of proper Gaussian signaling, provide an opportunity to further improve the achievable rates of Gaussian MIMO-ICs by employing improper Gaussian signaling. To this end, this paper proposes widely linear precoding, which efficiently maps proper information-bearing signals to improper transmitted signals at each transmitter for any given pair of transmit covariance and pseudo-covariance matrices. In particular, for the case of two-user Gaussian single-input single-output interference channel (SISO-IC), we propose a joint covariance and pseudo-covariance optimization algorithm with improper Gaussian signaling to achieve the Pareto-optimal rates. By utilizing the separable structure of the achievable rate expression, an alternative algorithm with separate covariance and pseudo-covariance optimization is also proposed, which guarantees the rate improvement over conventional proper Gaussian signaling.Comment: Accepted by IEEE Transactions on Signal Processin

Web Service Discovery Based on Past User Experience

Web service technology provides a way for simplifying interoperability among different organizations. A piece of functionality available as a web service can be involved in a new business process. Given the steadily growing number of available web services, it is hard for developers to find services appropriate for their needs. The main research efforts in this area are oriented on developing a mechanism for semantic web service description and matching. In this paper, we present an alternative approach for supporting users in web service discovery. Our system implements the implicit culture approach for recommending web services to developers based on the history of decisions made by other developers with similar needs. We explain the main ideas underlying our approach and report on experimental results

Establishing gold standard approaches to rapid tranquillisation: a review and discussion of the evidence on the safety and efficacy of medications currently used

Background: Rapid tranquillisation is used when control of agitation, aggression or excitement is required. Throughout the UK there is no consensus over the choice of drugs to be used as first line treatment. The NICE guideline on the management of violent behaviour involving psychiatric inpatients conducted a systematic examination of the literature relating to the effectiveness and safety of rapid tranquillisation (NICE, 2005). This paper presents the key findings from that review and key guideline recommendations generated, and discusses the implications for practice of more recent research and information. Aims: To examine the evidence on the efficacy and safety of medications used for rapid tranquillisation in inpatient psychiatric settings. Method: Systematic review of current guidelines and phase III randomised, controlled trials of medication used for rapid tranquillisation. Formal consensus methods were used to generate clinically relevant recommendations to support safe and effective prescribing of rapid tranquillisation in the development of a NICE guideline. Findings: There is a lack of high quality clinical trial evidence in the UK and therefore a ‘gold standard’ medication regime for rapid tranquillisation has not been established. Rapid tranquillisation and clinical practice: The NICE guideline produced 35 recommendations on rapid tranquillisation practice for the UK, with the primary aim of calming the service user to enable the use of psychosocial techniques. Conclusions and implications for clinical practice: Further UK specific research is urgently needed that provides the clinician with a hierarchy of options for the clinical practice of rapid tranquillisation