22,554 research outputs found
Data-driven modelling of biological multi-scale processes
Biological processes involve a variety of spatial and temporal scales. A
holistic understanding of many biological processes therefore requires
multi-scale models which capture the relevant properties on all these scales.
In this manuscript we review mathematical modelling approaches used to describe
the individual spatial scales and how they are integrated into holistic models.
We discuss the relation between spatial and temporal scales and the implication
of that on multi-scale modelling. Based upon this overview over
state-of-the-art modelling approaches, we formulate key challenges in
mathematical and computational modelling of biological multi-scale and
multi-physics processes. In particular, we considered the availability of
analysis tools for multi-scale models and model-based multi-scale data
integration. We provide a compact review of methods for model-based data
integration and model-based hypothesis testing. Furthermore, novel approaches
and recent trends are discussed, including computation time reduction using
reduced order and surrogate models, which contribute to the solution of
inference problems. We conclude the manuscript by providing a few ideas for the
development of tailored multi-scale inference methods.Comment: This manuscript will appear in the Journal of Coupled Systems and
Multiscale Dynamics (American Scientific Publishers
A Case Study for Business Integration as a Service
This paper presents Business Integration as a Service (BIaaS) to allow two services to work together in the Cloud to achieve a streamline process. We illustrate this integration using two services; Return on Investment (ROI) Measurement as a Service (RMaaS) and Risk Analysis as a Service (RAaaS) in the case study at the University of Southampton. The case study demonstrates the cost-savings and the risk analysis achieved, so two services can work as a single service. Advanced techniques are used to demonstrate statistical services and 3D Visualisation services under the remit of RMaaS and Monte Carlo Simulation as a Service behind the design of RAaaS. Computational results are presented with their implications discussed. Different types of risks associated with Cloud adoption can be calculated easily, rapidly and accurately with the use of BIaaS. This case study confirms the benefits of BIaaS adoption, including cost reduction and improvements in efficiency and risk analysis. Implementation of BIaaS in other organisations is also discussed. Important data arising from the integration of RMaaS and RAaaS are useful for management and stakeholders of University of Southampton
A comparative study of multiple-criteria decision-making methods under stochastic inputs
This paper presents an application and extension of multiple-criteria decision-making (MCDM) methods to account for stochastic input variables. More in particular, a comparative study is carried out among well-known and widely-applied methods in MCDM, when applied to the reference problem of the selection of wind turbine support structures for a given deployment location. Along with data from industrial experts, six deterministic MCDM methods are studied, so as to determine the best alternative among the available options, assessed against selected criteria with a view toward assigning confidence levels to each option. Following an overview of the literature around MCDM problems, the best practice implementation of each method is presented aiming to assist stakeholders and decision-makers to support decisions in real-world applications, where many and often conflicting criteria are present within uncertain environments. The outcomes of this research highlight that more sophisticated methods, such as technique for the order of preference by similarity to the ideal solution (TOPSIS) and Preference Ranking Organization method for enrichment evaluation (PROMETHEE), better predict the optimum design alternative
Mesoscopic simulation of diffusive contaminant spreading in gas flows at low pressure
Many modern production and measurement facilities incorporate multiphase
systems at low pressures. In this region of flows at small, non-zero Knudsen-
and low Mach numbers the classical mesoscopic Monte Carlo methods become
increasingly numerically costly. To increase the numerical efficiency of
simulations hybrid models are promising. In this contribution, we propose a
novel efficient simulation approach for the simulation of two phase flows with
a large concentration imbalance in a low pressure environment in the low
intermediate Knudsen regime. Our hybrid model comprises a lattice-Boltzmann
method corrected for the lower intermediate Kn regime proposed by Zhang et al.
for the simulation of an ambient flow field. A coupled event-driven
Monte-Carlo-style Boltzmann solver is employed to describe particles of a
second species of low concentration. In order to evaluate the model, standard
diffusivity and diffusion advection systems are considered.Comment: 9 pages, 8 figure
Investigation of Air Transportation Technology at Princeton University, 1989-1990
The Air Transportation Technology Program at Princeton University proceeded along six avenues during the past year: microburst hazards to aircraft; machine-intelligent, fault tolerant flight control; computer aided heuristics for piloted flight; stochastic robustness for flight control systems; neural networks for flight control; and computer aided control system design. These topics are briefly discussed, and an annotated bibliography of publications that appeared between January 1989 and June 1990 is given
Business Integration as a Service
This paper presents Business Integration as a Service (BIaS) which enables connections between services operating in the Cloud. BIaS integrates different services and business activities to achieve a streamline process. We illustrate this integration using two services; Return on Investment (ROI) Measurement as a Service (RMaaS) and Risk Analysis as a Service (RAaaS) in two case studies at the University of Southampton and Vodafone/Apple. The University of Southampton case study demonstrates the cost-savings and the risk analysis achieved, so two services can work as a single service. The Vodafone/Apple case study illustrates statistical analysis and 3D Visualisation of expected revenue and associated risk. These two cases confirm the benefits of BIaS adoption, including cost reduction and improvements in efficiency and risk analysis. Implementation of BIaS in other organisations is also discussed. Important data arising from the integration of RMaaS and RAaaS are useful for management of University of Southampton and potential and current investors for Vodafone/Apple
Spin-dynamics simulations of the triangular antiferromagnetic XY model
Using Monte Carlo and spin-dynamics methods, we have investigated the dynamic
behavior of the classical, antiferromagnetic XY model on a triangular lattice
with linear sizes . The temporal evolutions of spin configurations
were obtained by solving numerically the coupled equations of motion for each
spin using fourth-order Suzuki-Trotter decompositions of exponential operators.
From space- and time-displaced spin-spin correlation functions and their
space-time Fourier transforms we obtained the dynamic structure factor for momentum and frequency . Below
(Kosterlitz-Thouless transition), both the in-plane () and the
out-of-plane () components of exhibit very strong
and sharp spin-wave peaks. Well above , and
apparently display a central peak, and spin-wave signatures are still seen in
. In addition, we also observed an almost dispersionless domain-wall
peak at high below (Ising transition), where long-range order
appears in the staggered chirality. Above , the domain-wall peak
disappears for all . The lineshape of these peaks is captured reasonably
well by a Lorentzian form. Using a dynamic finite-size scaling theory, we
determined the dynamic critical exponent = 1.002(3). We found that our
results demonstrate the consistency of the dynamic finite-size scaling theory
for the characteristic frequeny and the dynamic structure factor
itself.Comment: 8 pages, RevTex, 10 figures, submitted to PR
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