Machine learning with multimodal neuroimaging data to classify stages of Alzheimer’s disease: a systematic review and meta-analysis

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Deep learning of brain asymmetry digital biomarkers to support early diagnosis of cognitive decline and dementia

Early identification of degenerative processes in the human brain is essential for proper care and treatment. This may involve different instrumental diagnostic methods, including the most popular computer tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) scans. These technologies provide detailed information about the shape, size, and function of the human brain. Structural and functional cerebral changes can be detected by computational algorithms and used to diagnose dementia and its stages (amnestic early mild cognitive impairment - EMCI, Alzheimer’s Disease - AD). They can help monitor the progress of the disease. Transformation shifts in the degree of asymmetry between the left and right hemispheres illustrate the initialization or development of a pathological process in the brain. In this vein, this study proposes a new digital biomarker for the diagnosis of early dementia based on the detection of image asymmetries and crosssectional comparison of NC (normal cognitively), EMCI and AD subjects. Features of brain asymmetries extracted from MRI of the ADNI and OASIS databases are used to analyze structural brain changes and machine learning classification of the pathology. The experimental part of the study includes results of supervised machine learning algorithms and transfer learning architectures of convolutional neural networks for distinguishing between cognitively normal subjects and patients with early or progressive dementia. The proposed pipeline offers a low-cost imaging biomarker for the classification of dementia. It can be potentially helpful to other brain degenerative disorders accompanied by changes in brain asymmetries

Umělá inteligence v kybernetické bezpečnosti

Artifcial intelligence (AI) and machine learning (ML) have grown rapidly in recent years, and their applications in practice can be seen in many felds, ranging from facial recognition to image analysis. Recent developments in Artificial intelligence have a vast transformative potential for both cybersecurity defenders and cybercriminals. Anti-malware solutions adopt intelligent techniques to detect and prevent threats to the digital space. In contrast, cybercriminals are aware of the new prospects too and likely to adapt AI techniques to their operations. This thesis presents advances made so far in the field of applying AI techniques in cybersecurity for combating against cyber threats, to demonstrate how this promising technology can be a useful tool for detection and prevention of cyberattacks. Furthermore, the research examines how transnational criminal organizations and cybercriminals may leverage developing AI technology to conduct more sophisticated criminal activities. Next, the research outlines the possible dynamic new kind of malware, called X-Ware and X-sWarm, which simulates the swarm system behaviour and integrates the neural network to operate more efficiently as a background for the forthcoming anti-malware solution. This research proposes how to record and visualize the behaviour of these type of malware when it propagates through the file system, computer network (virus process is known) or by observed data analysis (virus process is not known and we observe only the data from the system). Finally, a paradigm of an anti-malware solution, named Multi agent antivirus system has been proposed in the thesis that gives the insight to develop a more robust, adaptive and flexible defence system.Význam umělé inteligence (AI) a strojového učení (ML) v posledních letech rychle rostl a na jejich aplikacích lze vidět, že v mnoha oblastech, od rozpoznávání obličeje až po analýzu obrazu, byl učiněn velký pokrok. Poslední vývoj v oblasti umělé inteligence má obrovský potenciál jak pro obránce v oblasti kybernetické bezpečnosti, tak pro ůtočníky. AI se stává řešením v otázce obrany proti modernímu malware a hraje tak důležitou roli v detekci a prevenci hrozeb v digitálním prostoru. Naproti tomu kyberzločinci jsou si vědomi nových vyhlídek ve spojení s AI a pravděpodobně přizpůsobí tyto techniky novým generacím malware, vektorům útoku a celkově jejich operacím. Tato práce představuje dosavadní pokroky aplikace technik AI v oblasti kybernetické bezpečnosti. V této oblasti tzn. v boji proti kybernetickým hrozbám se ukázuje jako slibná technologie a užitečný nástroj pro detekci a prevenci kybernetických útoků. V práci si rovněž pokládme otázku, jak mohou nadnárodní zločinecké organizace a počítačoví zločinci využít vyvíjející se technologii umělé inteligence k provádění sofistikovanějších trestných činností. Konečně, výzkum nastíní možný nový druh malware, nazvaný X-Ware, který simuluje chování hejnového systému a integruje neuronovou síť tak, aby fungovala efektivněji a tak se celý X-Ware a X-sWarm dal použít nejen jako kybernetická zbraň na útok, ale i jako antivirové obranné řešení. Tento výzkum navrhuje, jak zaznamenat a vizualizovat chování X-Ware, když se šíří prostřednictvím systému souborů, sítí a to jak analýzou jeho dynamiky (proces je znám), tak analýzou dat (proces není znám, pozorujeme jen data). Nakonec bylo v disertační práci navrženo paradigma řešení proti malwaru, jež bylo nazváno „Multi agent antivirus system“. Tato práce tedy poskytuje pohled na vývoj robustnějšího, adaptivnějšího a flexibilnějšího obranného systému.460 - Katedra informatikyvyhově

A Study of the Thermodynamics of Small Systems and Phase Transition in Bulk Square Well-Hard Disk Binary Mixture

Under the umbrella of statistical mechanics and particle-based simulations, two distinct problems have been discussed in this study. The first part included systems of finite clusters of three and 13 particles, where the particles are interacting via Lennard Jones potential. A machine learning technique, Diffusion Maps (DMap), has been employed to the large datasets of thermodynamically small systems from Monte Carlo simulations in order to identify the structural and energetic changes in these systems. DMap suggests at most three dimensions are required to describe and identify the systems with 9 (N = 3) and 39 (N = 13) dimensions. At the end of the study, a model has been proposed to functionalize the potential energy in terms of geometric variables that are identified with a heuristic screening. Investigation of the thermodynamics of bulk systems was another major focus of this thesis. The phase diagrams of the pure square-well solids and binary mixture of square-well and hard-disk particles, under the assumption of a pseudo-single- component model, have been constructed, and the phase equilibria behaviors were discussed. The datasets were also created in Monte Carlo simulations. The results showed isostructural solid-solid phase transition, which was previously identified that the pure square-well system with a very short range of attraction undergoes, also occurs in the presence of additional hard-disk components, namely for the binary mixture of square-well and hard-disk systems

Computational Intelligence in Healthcare

The number of patient health data has been estimated to have reached 2314 exabytes by 2020. Traditional data analysis techniques are unsuitable to extract useful information from such a vast quantity of data. Thus, intelligent data analysis methods combining human expertise and computational models for accurate and in-depth data analysis are necessary. The technological revolution and medical advances made by combining vast quantities of available data, cloud computing services, and AI-based solutions can provide expert insight and analysis on a mass scale and at a relatively low cost. Computational intelligence (CI) methods, such as fuzzy models, artificial neural networks, evolutionary algorithms, and probabilistic methods, have recently emerged as promising tools for the development and application of intelligent systems in healthcare practice. CI-based systems can learn from data and evolve according to changes in the environments by taking into account the uncertainty characterizing health data, including omics data, clinical data, sensor, and imaging data. The use of CI in healthcare can improve the processing of such data to develop intelligent solutions for prevention, diagnosis, treatment, and follow-up, as well as for the analysis of administrative processes. The present Special Issue on computational intelligence for healthcare is intended to show the potential and the practical impacts of CI techniques in challenging healthcare applications