Correlated Multimodal Imaging in Life Sciences:Expanding the Biomedical Horizon

International audienceThe frontiers of bioimaging are currently being pushed toward the integration and correlation of several modalities to tackle biomedical research questions holistically and across multiple scales. Correlated Multimodal Imaging (CMI) gathers information about exactly the same specimen with two or more complementary modalities that-in combination-create a composite and complementary view of the sample (including insights into structure, function, dynamics and molecular composition). CMI allows to describe biomedical processes within their overall spatio-temporal context and gain a mechanistic understanding of cells, tissues, diseases or organisms by untangling their molecular mechanisms within their native environment. The two best-established CMI implementations for small animals and model organisms are hardware-fused platforms in preclinical imaging (Hybrid Imaging) and Correlated Light and Electron Microscopy (CLEM) in biological imaging. Although the merits of Preclinical Hybrid Imaging (PHI) and CLEM are well-established, both approaches would benefit from standardization of protocols, ontologies and data handling, and the development of optimized and advanced implementations. Specifically, CMI pipelines that aim at bridging preclinical and biological imaging beyond CLEM and PHI are rare but bear great potential to substantially advance both bioimaging and biomedical research. CMI faces three mai

An overview of robotics and autonomous systems for harsh environments

Across a wide range of industries and applications, robotics and autonomous systems can fulfil the crucial and challenging tasks such as inspection, exploration, monitoring, drilling, sampling and mapping in areas of scientific discovery, disaster prevention, human rescue and infrastructure management, etc. However, in many situations, the associated environment is either too dangerous or inaccessible to humans. Hence, a wide range of robots have been developed and deployed to replace or aid humans in these activities. A look at these harsh environment applications of robotics demonstrate the diversity of technologies developed. This paper reviews some key application areas of robotics that involve interactions with harsh environments (such as search and rescue, space exploration, and deep-sea operations), gives an overview of the developed technologies and provides a discussion of the key trends and future directions common to many of these areas

Indoor and outdoor localization for AGVs in the primary aluminum industry

The goal of this project is to analyze two types of AGV indoor and outdoor localization techniques in an aluminum smelter building with a particular operative vehicle. The indoor localization is performed with the ARTag markers system while the outdoor localization employs multiple Wi-Fi transceivers to trilaterate the position of the vehicle based on the RSSI value. Finally, raw estimated pose is fused with the IMU sensor data using the extended kalman filter to increase localization accuracy.openEmbargo tempraneo per motivi di segretezza e/o di proprietà dei risultati e informazioni di enti esterni o aziende private che hanno partecipato alla realizzazione del lavoro di ricerca relativo alla tes