Deep Learning in Cardiology

The medical field is creating large amount of data that physicians are unable to decipher and use efficiently. Moreover, rule-based expert systems are inefficient in solving complicated medical tasks or for creating insights using big data. Deep learning has emerged as a more accurate and effective technology in a wide range of medical problems such as diagnosis, prediction and intervention. Deep learning is a representation learning method that consists of layers that transform the data non-linearly, thus, revealing hierarchical relationships and structures. In this review we survey deep learning application papers that use structured data, signal and imaging modalities from cardiology. We discuss the advantages and limitations of applying deep learning in cardiology that also apply in medicine in general, while proposing certain directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table

Wavelet Based Dictionaries for Dimensionality Reduction of ECG Signals

Dimensionality reduction of ECG signals is considered within the framework of sparse representation. The approach constructs the signal model by selecting elementary components from a redundant dictionary via a greedy strategy. The proposed wavelet dictionaries are built from the multiresolution scheme, but translating the prototypes within a shorter step than that corresponding to the wavelet basis. The reduced representation of the signal is shown to be suitable for compression at low level distortion. In that regard, compression results are superior to previously reported benchmarks on the MIT-BIH Arrhythmia data set

Boosting the Battery Life of Wearables for Health Monitoring Through the Compression of Biosignals

Modern wearable Internet of Things (IoT) devices enable the monitoring of vital parameters such as heart or respiratory (RESP) rates, electrocardiography (ECG), photo-plethysmographic (PPG) signals within e-health applications. A common issue of wearable technology is that signal transmission is power-demanding and, as such, devices require frequent battery charges and this poses serious limitations to the continuous monitoring of vitals. To ameliorate this, we advocate the use of lossy signal compression as a means to decrease the data size of the gathered biosignals and, in turn, boost the battery life of wearables and allow for fine-grained and long-term monitoring. Considering 1-D biosignals such as ECG, RESP, and PPG, which are often available from commercial wearable IoT devices, we provide a thorough review of existing biosignal compression algorithms. Besides, we present novel approaches based on online dictionaries, elucidating their operating principles and providing a quantitative assessment of compression, reconstruction and energy consumption performance of all schemes. As we quantify, the most efficient schemes allow reductions in the signal size of up to 100 times, which entail similar reductions in the energy demand, by still keeping the reconstruction error within 4% of the peak-to-peak signal amplitude. Finally, avenues for future research are discussed. © 2014 IEEE

Continuous Estimation of Smoking Lapse Risk from Noisy Wrist Sensor Data Using Sparse and Positive-Only Labels

Estimating the imminent risk of adverse health behaviors provides opportunities for developing effective behavioral intervention mechanisms to prevent the occurrence of the target behavior. One of the key goals is to find opportune moments for intervention by passively detecting the rising risk of an imminent adverse behavior. Significant progress in mobile health research and the ability to continuously sense internal and external states of individual health and behavior has paved the way for detecting diverse risk factors from mobile sensor data. The next frontier in this research is to account for the combined effects of these risk factors to produce a composite risk score of adverse behaviors using wearable sensors convenient for daily use. Developing a machine learning-based model for assessing the risk of smoking lapse in the natural environment faces significant outstanding challenges requiring the development of novel and unique methodologies for each of them. The first challenge is coming up with an accurate representation of noisy and incomplete sensor data to encode the present and historical influence of behavioral cues, mental states, and the interactions of individuals with their ever-changing environment. The next noteworthy challenge is the absence of confirmed negative labels of low-risk states and adequate precise annotations of high-risk states. Finally, the model should work on convenient wearable devices to facilitate widespread adoption in research and practice. In this dissertation, we develop methods that account for the multi-faceted nature of smoking lapse behavior to train and evaluate a machine learning model capable of estimating composite risk scores in the natural environment. We first develop mRisk, which combines the effects of various mHealth biomarkers such as stress, physical activity, and location history in producing the risk of smoking lapse using sequential deep neural networks. We propose an event-based encoding of sensor data to reduce the effect of noises and then present an approach to efficiently model the historical influence of recent and past sensor-derived contexts on the likelihood of smoking lapse. To circumvent the lack of confirmed negative labels (i.e., annotated low-risk moments) and only a few positive labels (i.e., sensor-based detection of smoking lapse corroborated by self-reports), we propose a new loss function to accurately optimize the models. We build the mRisk models using biomarker (stress, physical activity) streams derived from chest-worn sensors. Adapting the models to work with less invasive and more convenient wrist-based sensors requires adapting the biomarker detection models to work with wrist-worn sensor data. To that end, we develop robust stress and activity inference methodologies from noisy wrist-sensor data. We first propose CQP, which quantifies wrist-sensor collected PPG data quality. Next, we show that integrating CQP within the inference pipeline improves accuracy-yield trade-offs associated with stress detection from wrist-worn PPG sensors in the natural environment. mRisk also requires sensor-based precise detection of smoking events and confirmation through self-reports to extract positive labels. Hence, we develop rSmoke, an orientation-invariant smoking detection model that is robust to the variations in sensor data resulting from orientation switches in the field. We train the proposed mRisk risk estimation models using the wrist-based inferences of lapse risk factors. To evaluate the utility of the risk models, we simulate the delivery of intelligent smoking interventions to at-risk participants as informed by the composite risk scores. Our results demonstrate the envisaged impact of machine learning-based models operating on wrist-worn wearable sensor data to output continuous smoking lapse risk scores. The novel methodologies we propose throughout this dissertation help instigate a new frontier in smoking research that can potentially improve the smoking abstinence rate in participants willing to quit

Advanced Biometrics with Deep Learning

Biometrics, such as fingerprint, iris, face, hand print, hand vein, speech and gait recognition, etc., as a means of identity management have become commonplace nowadays for various applications. Biometric systems follow a typical pipeline, that is composed of separate preprocessing, feature extraction and classification. Deep learning as a data-driven representation learning approach has been shown to be a promising alternative to conventional data-agnostic and handcrafted pre-processing and feature extraction for biometric systems. Furthermore, deep learning offers an end-to-end learning paradigm to unify preprocessing, feature extraction, and recognition, based solely on biometric data. This Special Issue has collected 12 high-quality, state-of-the-art research papers that deal with challenging issues in advanced biometric systems based on deep learning. The 12 papers can be divided into 4 categories according to biometric modality; namely, face biometrics, medical electronic signals (EEG and ECG), voice print, and others

System-on-Chip Solution for Patients Biometric: A Compressive Sensing-Based Approach

IEEE The ever-increasing demand for biometric solutions for the internet of thing (IoT)-based connected health applications is mainly driven by the need to tackle fraud issues, along with the imperative to improve patient privacy, safety and personalized medical assistance. However, the advantages offered by the IoT platforms come with the burden of big data and its associated challenges in terms of computing complexity, bandwidth availability and power consumption. This paper proposes a solution to tackle both privacy issues and big data transmission by incorporating the theory of compressive sensing (CS) and a simple, yet, efficient identification mechanism using the electrocardiogram (ECG) signal as a biometric trait. Moreover, the paper presents the hardware implementation of the proposed solution on a system on chip (SoC) platform with an optimized architecture to further reduce hardware resource usage. First, we investigate the feasibility of compressing the ECG data while maintaining a high identification quality. The obtained results show a 98.88% identification rate using only a compression ratio of 30%. Furthermore, the proposed system has been implemented on a Zynq SoC using heterogeneous software/hardware solution, which is able to accelerate the software implementation by a factor of 7.73 with a power consumption of 2.318 W

Spatial Characterization and Estimation of Intracardiac Propagation Patterns During Atrial Fibrillation

This doctoral thesis is in the field of biomedical signal processing with focus on methods for the analysis of atrial fibrillation (AF). Paper I of the present thesis addresses the challenge of extracting spatial properties of AF from body surface signals. Different parameters are extracted to estimate the preferred direction of atrial activation and the complexity of the atrial activation pattern. In addition, the relation of the spatial properties to AF organization, which is quantified by AF frequency, is evaluated. While no significant correlation between the preferred direction of atrial activation and AF frequency could be observed, the complexity of the atrial activation pattern was found to increase with AF frequency. The remaining three papers deal with the analysis of the propagation of the electrical activity in the atria during AF based on intracardiac signals. In Paper II, a time-domain method to quantify propagation patterns along a linear catheter based on the detected atrial activation times is developed. Taking aspects on intra-atrial signal organization into account, the detected activation times are combined into wavefronts, and parameters related to the consistency of the wavefronts over time and the activation order along the catheter are extracted. Furthermore, the potential relationship of the extracted parameters to established measures from body surface signals is investigated. While the degree of wavefront consistency was not reflected by the applied body surface measures, AF frequency could distinguish between recordings with different degrees of intra-atrial signal organization. This supports the role of AF frequency as an organization measure of AF. In Paper III, a novel method to analyze intracardiac propagation patterns based on causality analysis in the frequency domain is introduced. In particular, the approach is based on the partial directed coherence (PDC), which evaluates directional coupling between multiple signals in the frequency domain. The potential of the method is illustrated with simulation scenarios based on a detailed ionic model of the human atrial cell as well as with real data recordings, selected to present typical propagation mechanisms and recording situations in atrial tachyarrhythmias. For simulated data, the PDC is correctly reflecting the direction of coupling and thus the propagation between all recording sites. For real data, clear propagation patterns are identified which agree with previous clinical observations. Thus, the results illustrate the ability of the novel approach to identify propagation patterns from intracardiac signals during AF which can provide important information about the underlying AF mechanisms, potentially improving the planning and outcome of ablation. However, spurious couplings over long distances can be observed when analyzing real data comprised by a large number of simultaneously recorded signals, which gives room for further improvement of the method. The derivation of the PDC is entirely based on the fit of a multivariate autoregressive (MVAR) model, commonly estimated by the least-squares (LS) method. In Paper IV, the adaptive group least absolute selection and shrinkage operator (LASSO) is introduced in order to avoid overfitting of the MVAR model and to incorporate prior information such as sparsity of the solution. The sparsity can be motivated by the observation that direct couplings over longer distances are likely to be zero during AF; an information which has been further incorporated by proposing distance-adaptive group LASSO. In simulations, adaptive and distance-adaptive group LASSO are found to be superior to LS estimation in terms of both detection and estimation accuracy. In addition, the results of both simulations and real data analysis indicate that further improvements can be achieved when the distance between the recording sites is known or can be estimated. This further promotes the PDC as a method for analysis of AF propagation patterns, which may contribute to a better understanding of AF mechanisms as well as improved AF treatment

Applications of Signal Analysis to Atrial Fibrillation

This work was supported by projects TEC2010–20633 from the Spanish Ministry of Science and Innovation and PPII11–0194–8121 from Junta de Comunidades de Castilla-La ManchaRieta Ibañez, JJ.; Alcaraz Martínez, R. (2013). Applications of Signal Analysis to Atrial Fibrillation. En Atrial Fibrillation - Mechanisms and Treatment. InTech. 155-180. https://doi.org/10.5772/5340915518