251,193 research outputs found
Quo Vadis, Action Recognition? A New Model and the Kinetics Dataset
The paucity of videos in current action classification datasets (UCF-101 and
HMDB-51) has made it difficult to identify good video architectures, as most
methods obtain similar performance on existing small-scale benchmarks. This
paper re-evaluates state-of-the-art architectures in light of the new Kinetics
Human Action Video dataset. Kinetics has two orders of magnitude more data,
with 400 human action classes and over 400 clips per class, and is collected
from realistic, challenging YouTube videos. We provide an analysis on how
current architectures fare on the task of action classification on this dataset
and how much performance improves on the smaller benchmark datasets after
pre-training on Kinetics.
We also introduce a new Two-Stream Inflated 3D ConvNet (I3D) that is based on
2D ConvNet inflation: filters and pooling kernels of very deep image
classification ConvNets are expanded into 3D, making it possible to learn
seamless spatio-temporal feature extractors from video while leveraging
successful ImageNet architecture designs and even their parameters. We show
that, after pre-training on Kinetics, I3D models considerably improve upon the
state-of-the-art in action classification, reaching 80.9% on HMDB-51 and 98.0%
on UCF-101.Comment: Removed references to mini-kinetics dataset that was never made
publicly available and repeated all experiments on the full Kinetics datase
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Commentary on child-adult differences in muscle activation - A review
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A model of the electrical behaviour of myelinated sensory nerve fibres based on human data
Calculation of the response of human myelinated sensory nerve fibres to spinal cord stimulation initiated the development of a fibre model based on electro-physiological and morphometric data for human sensory nerve fibres. The model encompasses a mathematical description of the kinetics of the nodal membrane, and a non-linear fibre geometry. Fine tuning of only a few, not well-established parameters was performed by fitting the shape of a propagating action potential and its diameter-dependent propagation velocity. The quantitative behaviour of this model corresponds better to experimentally determined human fibre properties than other mammalian, non-human models do. Typical characteristics, such as the shape of the action potential, the propagation velocity and the strength-duration behaviour show a good fit with experimental data. The introduced diameter-dependent parameters did not result in a noticeable diameter dependency of action potential duration and refractory period. The presented model provides an improved tool to analyse the electrical behaviour of human myelinated sensory nerve fibres
Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.
We developed a systematic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs of 73 cancer genes with dual guide RNAs in three cell lines, comprising 141,912 tests of interaction. Numerous therapeutically relevant interactions were identified, and these patterns replicated with combinatorial drugs at 75% precision. From these results, we anticipate that cellular context will be critical to synthetic-lethal therapies
Self-organizing, two-temperature Ising model describing human segregation
A two-temperature Ising-Schelling model is introduced and studied for
describing human segregation. The self-organized Ising model with Glauber
kinetics simulated by M\"uller et al. exhibits a phase transition between
segregated and mixed phases mimicking the change of tolerance (local
temperature) of individuals. The effect of external noise is considered here as
a second temperature added to the decision of individuals who consider change
of accommodation. A numerical evidence is presented for a discontinuous phase
transition of the magnetization.Comment: 5 pages, 4 page
Sensing metabolites using donor-acceptor nanodistributions in fluorescence resonance energy transfer
Before fluorescence sensing techniques can be applied to media as delicate and complicated as human tissue, an adequate interpretation of the measured observables is required, i.e., an inverse problem needs to be solved. Recently we have solved the inverse problem relating to the kinetics of fluorescence resonance energy transfer (FRET), which clears the way for the determination of the donor-acceptor distribution function in FRET assays. In this letter this approach to monitoring metabolic processes is highlighted and the application to glucose sensing demonstrated
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