State of Alaska Election Security Project Phase 2 Report

A laska’s election system is among the most secure in the country, and it has a number of safeguards other states are now adopting. But the technology Alaska uses to record and count votes could be improved— and the state’s huge size, limited road system, and scattered communities also create special challenges for insuring the integrity of the vote. In this second phase of an ongoing study of Alaska’s election security, we recommend ways of strengthening the system—not only the technology but also the election procedures. The lieutenant governor and the Division of Elections asked the University of Alaska Anchorage to do this evaluation, which began in September 2007.Lieutenant Governor Sean Parnell. State of Alaska Division of Elections.List of Appendices / Glossary / Study Team / Acknowledgments / Introduction / Summary of Recommendations / Part 1 Defense in Depth / Part 2 Fortification of Systems / Part 3 Confidence in Outcomes / Conclusions / Proposed Statement of Work for Phase 3: Implementation / Reference

Handgrip strength time profile and frailty: an exploratory study

This study aims to explore the use of force vs. time data obtained from an isometric handgrip test to match a frailty state based on the TFI score. BodyGrip, a novel prototype system, is used for handgrip strength over 10 s time interval tests. A cross-sectional study with a non-probabilistic sample of community-dwelling elderly women was conducted. The force/time data collected from the dominant handgrip strength test, together with the Tilburg Frailty Indicator (TFI) test results, were used to train artificial neural networks. Different models were tested, and the frailty matching of TFI scores reached a minimum accuracy of 75%. Despite the small sample size, the BodyGrip system appears to be a promising tool for exploring new frailty-related features. The adopted strategy foresees ultimately configuring the system to be used as an expedite mode for identifying individuals at risk, allowing an easy, quick, and frequent person-centered care approach. Additionally, it is suitable for following up of the elderly in particular, and it may assume a relevant role in the mitigation of the increase in frailty evolution during and after the imposed isolation of the COVID-19 pandemic. Further use of the system will improve the robustness of the artificial neural network algorithm.info:eu-repo/semantics/publishedVersio

Using a systems approach to analyze the operational safety of dams

Dam systems are arrangements of interacting components that store and convey water for beneficial purposes. Dam failures are associated with extreme consequences to human life, the environment and the economy. Existing techniques for dam safety analysis tend to focus on verifying system performance at the edge of the design envelope. In analyzing the events which occur within the design envelope, linear chain-of-events models are often used to analyze the potential outcomes for the system. These chain-of-events models require that combinations of conditions are identified at the outset of the analysis, which can be very cumbersome given the number of physically possible combinations. Additional complications arising from feedback behaviour and time are not easily overcome using existing tools. Recent work in the industry has begun to focus on systems approaches to the problem, especially stochastic simulation. Given current computational abilities, stochastic simulation may not be capable of analyzing combinations of events that have a low combined probability but potentially extreme consequences. This research focuses on developing and implementing a methodology that dynamically characterizes combinations of component operating states and their potential impacts on dam safety. Automated generation of scenarios is achieved through the use of a component operating states database that defines all possible combinations of component states (scenarios) using combinatorics. A Deterministic Monte Carlo simulation framework systematically characterizes each scenario through a number of iterations that vary adverse operating state timing, impacts and inflows. Component interactions and feedbacks are represented within the system dynamics simulation model. Simulation outcomes provide useful indicators for dam operators including conditional failure rates, times to failure, failure inflow thresholds, and reservoir level exceedance frequencies. Dynamic system response can be assessed directly from the simulation outcomes. The scenario results may be useful to dam owners in emergency decision-making to inform response timelines and to justify the allocation of resources. Results may also help inform the development of improved operating strategies or upgrade alternatives that can reduce the impacts of these extreme events. This work offers a significant improvement in the ability to systematically characterize the potential combinations of events and their consequences

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization

Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform

Caenorhabditis elegans is a valuable model organism in biomedical research that has led to major discoveries in the fields of neurodegeneration, cancer and aging. Because movement phenotypes are commonly used and represent strong indicators of C. elegans fitness, there is an increasing need to replace manual assessments of worm motility with automated measurements to increase throughput and minimize observer biases. Here, we provide a protocol for the implementation of the improved wide field-of-view nematode tracking platform (WF-NTP), which enables the simultaneous analysis of hundreds of worms with respect to multiple behavioral parameters. The protocol takes only a few hours to complete, excluding the time spent culturing C. elegans, and includes (i) experimental design and preparation of samples, (ii) data recording, (iii) software management with appropriate parameter choices and (iv) post-experimental data analysis. We compare the WF-NTP with other existing worm trackers, including those having high spatial resolution. The main benefits of WF-NTP relate to the high number of worms that can be assessed at the same time on a whole-plate basis and the number of phenotypes that can be screened for simultaneously