How Memory Conforms to Brain Development

Nature exhibits countless examples of adaptive networks, whose topology evolves constantly coupled with the activity due to its function. The brain is an illustrative example of a system in which a dynamic complex network develops by the generation and pruning of synaptic contacts between neurons while memories are acquired and consolidated. Here, we consider a recently proposed brain developing model to study how mechanisms responsible for the evolution of brain structure affect and are affected by memory storage processes. Following recent experimental observations, we assume that the basic rules for adding and removing synapses depend on local synaptic currents at the respective neurons in addition to global mechanisms depending on the mean connectivity. In this way a feedback loop between “form” and “function” spontaneously emerges that influences the ability of the system to optimally store and retrieve sensory information in patterns of brain activity or memories. In particular, we report here that, as a consequence of such a feedback-loop, oscillations in the activity of the system among the memorized patterns can occur, depending on parameters, reminding mind dynamical processes. Such oscillations have their origin in the destabilization of memory attractors due to the pruning dynamics, which induces a kind of structural disorder or noise in the system at a long-term scale. This constantly modifies the synaptic disorder induced by the interference among the many patterns of activity memorized in the system. Such new intriguing oscillatory behavior is to be associated only to long-term synaptic mechanisms during the network evolution dynamics, and it does not depend on short-term synaptic processes, as assumed in other studies, that are not present in our model.Financial support from the Spanish Ministry of Science and Technology, and the Agencia Española de Investigación (AEI) under grant FIS2017-84256-P (FEDER funds) and from the Obra Social La Caixa (ID 100010434, with code LCF/BQ/ES15/10360004). This study has been also partially financed by the Consejería de Conocimiento, Investigación y Universidad, Junta de Andalucía and European Regional Development Fund (ERDF), with reference SOMM17/6105/UGR

Computing phonological generalization over real speech exemplars

Though it has attracted growing attention from phonologists and phoneticians Exemplar Theory (e g Bybee 2001) has hitherto lacked an explicit production model that can apply to speech signals An adequate model must be able to generalize but this presents the problem of how to generate an output that generalizes over a collection of unique variable-length signals Rather than resorting to a priori phonological units such as phones we adopt a dynamic programming approach using an optimization criterion that is sensitive to the frequency of similar subsequences within other exemplars the Phonological Exemplar-Based Learning System We show that PEBLS displays pattern-entrenchment behaviour central to Exemplar Theory s account of phonologization (C) 2010 Elsevier Ltd All rights reserve

The importance of quantum decoherence in brain processes

It is shown how environmental decoherence plays an essential and constructive role in a quantum mechanical theory of brain process that has significant explanatory power.Comment: Submitted to Phys. Rev, E. on Oct 6, 200

Learning and memory in machines and animals : an AI model that accounts for some neurobiological data

The CEL model of learning and memory (Components of Episodic Learning) [Granger 1982, 1983a, 1983b] provides a process model of certain aspects of learning and memory in animals and humans. The model consists of a set of asynchronous and semi-independent functional operators that collectively create and modify memory traces as a result of experience. The model conforms to relevant results in the learning literature of psychology and neurobiology. There are two goals to this work: one is to create a set of working learning systems that will improve their performance on the basis of experience, and the other is to compare these systems' performance with that of living systems, as a step towards the eventual comparative characterizations of different learning systems.Parts of the model have been implemented in the CEL-0 program, which operates in a 'Maze-World' simulated maze environment. The program exhibits simple exploratory behavior that leads to the acquisition of predictive and discriminatory schemata. A number of interesting theoretical predictions have arisen in part from observation of the operation of the program, some of which are currently being tested in neurobiological experiments. In particular, some neurobiological evidence for the existence of multiple, seperable memory systems in humans and animals is interpreted in terms of the model, and some new experiments are suggested arising from the model's predictions

Getting the best outcomes from epilepsy surgery.

Neurosurgery is an underutilized treatment that can potentially cure drug-refractory epilepsy. Careful, multidisciplinary presurgical evaluation is vital for selecting patients and to ensure optimal outcomes. Advances in neuroimaging have improved diagnosis and guided surgical intervention. Invasive electroencephalography allows the evaluation of complex patients who would otherwise not be candidates for neurosurgery. We review the current state of the assessment and selection of patients and consider established and novel surgical procedures and associated outcome data. We aim to dispel myths that may inhibit physicians from referring and patients from considering neurosurgical intervention for drug-refractory focal epilepsies. Ann Neurol 2018;83:676-690

A Neural Model of How The Brain Represents and Compares Numbers

Many psychophysical experiments have shown that the representation of numbers and numerical quantities in humans and animals is related to number magnitude. A neural network model is proposed to quantitatively simulate error rates in quantification and numerical comparison tasks, and reaction times for number priming and numerical assessment and comparison tasks. Transient responses to inputs arc integrated before they activate an ordered spatial map that selectively responds to the number of events in a sequence. The dynamics of numerical comparison are encoded in activity pattern changes within this spatial map. Such changes cause a "directional comparison wave" whose properties mimic data about numerical comparison. These model mechanisms are variants of neural mechanisms that have elsewhere been used to explain data about motion perception, attention shifts, and target tracking. Thus, the present model suggests how numerical representations may have emerged as specializations of more primitive mechanisms in the cortical Where processing stream.National Science Foundation (IRI-97-20333); Defense Advanced research Projects Agency and the Office of Naval Research (N00014-95-1-0409); National Institute of Health (1-R29-DC02952-01