47,981 research outputs found

    Grey-matter texture abnormalities and reduced hippocampal volume are distinguishing features of schizophrenia

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    Neurodevelopmental processes are widely believed to underlie schizophrenia. Analysis of brain texture from conventional magnetic resonance imaging (MRI) can detect disturbance in brain cytoarchitecture. We tested the hypothesis that patients with schizophrenia manifest quantitative differences in brain texture that, alongside discrete volumetric changes, may serve as an endophenotypic biomarker. Texture analysis (TA) of grey matter distribution and voxel-based morphometry (VBM) of regional brain volumes were applied to MRI scans of 27 patients with schizophrenia and 24 controls. Texture parameters (uniformity and entropy) were also used as covariates in VBM analyses to test for correspondence with regional brain volume. Linear discriminant analysis tested if texture and volumetric data predicted diagnostic group membership (schizophrenia or control). We found that uniformity and entropy of grey matter differed significantly between individuals with schizophrenia and controls at the fine spatial scale (filter width below 2 mm). Within the schizophrenia group, these texture parameters correlated with volumes of the left hippocampus, right amygdala and cerebellum. The best predictor of diagnostic group membership was the combination of fine texture heterogeneity and left hippocampal size. This study highlights the presence of distributed grey-matter abnormalities in schizophrenia, and their relation to focal structural abnormality of the hippocampus. The conjunction of these features has potential as a neuroimaging endophenotype of schizophrenia

    Region-based segmentation of images using syntactic visual features

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    This paper presents a robust and efficient method for segmentation of images into large regions that reflect the real world objects present in the scene. We propose an extension to the well known Recursive Shortest Spanning Tree (RSST) algorithm based on a new color model and so-called syntactic features [1]. We introduce practical solutions, integrated within the RSST framework, to structure analysis based on the shape and spatial configuration of image regions. We demonstrate that syntactic features provide a reliable basis for region merging criteria which prevent formation of regions spanning more than one semantic object, thereby significantly improving the perceptual quality of the output segmentation. Experiments indicate that the proposed features are generic in nature and allow satisfactory segmentation of real world images from various sources without adjustment to algorithm parameters

    Evaluation of Statistical Features for Medical Image Retrieval

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    In this paper we present a complete system allowing the classification of medical images in order to detect possible diseases present in them. The proposed method is developed in two distinct stages: calculation of descriptors and their classification. In the first stage we compute a vector of thirty-three statistical features: seven are related to statistics of the first level order, fifteen to that of second level where thirteen are calculated by means of co-occurrence matrices and two with absolute gradient; the last thirteen finally are calculated using run-length matrices. In the second phase, using the descriptors already calculated, there is the actual image classification. Naive Bayes, RBF, Support VectorMa- chine, K-Nearest Neighbor, Random Forest and Random Tree classifiers are used. The results obtained from the proposed system show that the analysis carried out both on textured and on medical images lead to have a high accuracy

    Color image segmentation using a spatial k-means clustering algorithm

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    This paper details the implementation of a new adaptive technique for color-texture segmentation that is a generalization of the standard K-Means algorithm. The standard K-Means algorithm produces accurate segmentation results only when applied to images defined by homogenous regions with respect to texture and color since no local constraints are applied to impose spatial continuity. In addition, the initialization of the K-Means algorithm is problematic and usually the initial cluster centers are randomly picked. In this paper we detail the implementation of a novel technique to select the dominant colors from the input image using the information from the color histograms. The main contribution of this work is the generalization of the K-Means algorithm that includes the primary features that describe the color smoothness and texture complexity in the process of pixel assignment. The resulting color segmentation scheme has been applied to a large number of natural images and the experimental data indicates the robustness of the new developed segmentation algorithm

    Tongue Image Analysis for Diabetes Mellitus Diagnosis Based on SOM Kohonen

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    Tongue diagnosis is an important diagnostic method for evaluating the condition of internal organ by looking at the image of tongue . However, due to its qualitative, subjective and experience-based nature, traditional tongue diagnosis has a very limited application in clinical medicine. Moreover, traditional tongue diagnosis is always concerned with the identification of syndromes rather than with the connection between tongue abnormal appearances and diseases. This is not well understood in Western medicine, thus greatly obstruct its wider use in the world. In this paper, we present a novel computerized tongue inspection method aiming to address these problems. First, two kinds of quantitative features, chromatic and textural measures, are extracted from tongue images by using popular digital image processing techniques. Then, SOM Kohonen are employed to model the relationship between these quantitative features and diseases. The effectiveness of the method is tested on 35 patients affected by Diabetes Mellitus as well as other 30 healthy volunteers, and the diagnostic results predicted by the previously trained SOM Kohonen classifiers are compared with the HOMA-B

    Diagnostic value of two dimensional shear wave elastography combined with texture analysis in early liver fibrosis.

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    BACKGROUND: Staging diagnosis of liver fibrosis is a prerequisite for timely diagnosis and therapy in patients with chronic hepatitis B. In recent years, ultrasound elastography has become an important method for clinical noninvasive assessment of liver fibrosis stage, but its diagnostic value for early liver fibrosis still needs to be further improved. In this study, the texture analysis was carried out on the basis of two dimensional shear wave elastography (2D-SWE), and the feasibility of 2D-SWE plus texture analysis in the diagnosis of early liver fibrosis was discussed. AIM: To assess the diagnostic value of 2D-SWE combined with textural analysis in liver fibrosis staging. METHODS: This study recruited 46 patients with chronic hepatitis B. Patients underwent 2D-SWE and texture analysis; Young\u27s modulus values and textural patterns were obtained, respectively. Textural pattern was analyzed with regard to contrast, correlation, angular second moment (ASM), and homogeneity. Pathological results of biopsy specimens were the gold standard; comparison and assessment of the diagnosis efficiency were conducted for 2D-SWE, texture analysis and their combination. RESULTS: 2D-SWE displayed diagnosis efficiency in early fibrosis, significant fibrosis, severe fibrosis, and early cirrhosis (AUC \u3e 0.7, P \u3c 0.05) with respective AUC values of 0.823 (0.678-0.921), 0.808 (0.662-0.911), 0.920 (0.798-0.980), and 0.855 (0.716-0.943). Contrast and homogeneity displayed independent diagnosis efficiency in liver fibrosis stage (AUC \u3e 0.7, P \u3c 0.05), whereas correlation and ASM showed limited values. AUC of contrast and homogeneity were respectively 0.906 (0.779-0.973), 0.835 (0.693-0.930), 0.807 (0.660-0.910) and 0.925 (0.805-0.983), 0.789 (0.639-0.897), 0.736 (0.582-0.858), 0.705 (0.549-0.883) and 0.798 (0.650-0.904) in four liver fibrosis stages, which exhibited equivalence to 2D-SWE in diagnostic efficiency (P \u3e 0.05). Combined diagnosis (PRE) displayed diagnostic efficiency (AUC \u3e 0.7, P \u3c 0.01) for all fibrosis stages with respective AUC of 0.952 (0.841-0.994), 0.896 (0.766-0.967), 0.978 (0.881-0.999), 0.947 (0.835-0.992). The combined diagnosis showed higher diagnosis efficiency over 2D-SWE in early liver fibrosis (P \u3c 0.05), whereas no significant differences were observed in other comparisons (P \u3e 0.05). CONCLUSION: Texture analysis was capable of diagnosing liver fibrosis stage, combined diagnosis had obvious advantages in early liver fibrosis, liver fibrosis stage might be related to the hepatic tissue hardness distribution
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