147 research outputs found
Dynamic functional connectivity in schizophrenia and bipolar disorder: A review of the evidence and associations with psychopathological features
Alterations of functional network connectivity have been implicated in the pathophysiology of schizophrenia (SCZ) and bipolar disorder (BD). Recent studies also suggest that the temporal dynamics of functional connec-tivity (dFC) can be altered in these disorders. Here, we summarized the existing literature on dFC in SCZ and BD, and their association with psychopathological and cognitive features. We systematically searched PubMed, Web of Science, and Scopus for studies investigating dFC in SCZ and BD and identified 77 studies. Our findings support a general model of dysconnectivity of dFC in SCZ, whereas a heterogeneous picture arose in BD. Although dFC alterations are more severe and widespread in SCZ compared to BD, dysfunctions of a triple network system underlying goal-directed behavior and sensory-motor networks were present in both disorders. Furthermore, in SCZ, positive and negative symptoms were associated with abnormal dFC.Implications for understanding the pathophysiology of disorders, the role of neurotransmitters, and treatments on dFC are discussed. The lack of standards for dFC metrics, replication studies, and the use of small samples represent major limitations for the field
The role of facial movements in emotion recognition
Most past research on emotion recognition has used photographs of posed expressions intended to depict the apex of the emotional display. Although these studies have provided important insights into how emotions are perceived in the face, they necessarily leave out any role of dynamic information. In this Review, we synthesize evidence from vision science, affective science and neuroscience to ask when, how and why dynamic information contributes to emotion recognition, beyond the information conveyed in static images. Dynamic displays offer distinctive temporal information such as the direction, quality and speed of movement, which recruit higher-level cognitive processes and support social and emotional inferences that enhance judgements of facial affect. The positive influence of dynamic information on emotion recognition is most evident in suboptimal conditions when observers are impaired and/or facial expressions are degraded or subtle. Dynamic displays further recruit early attentional and motivational resources in the perceiver, facilitating the prompt detection and prediction of others’ emotional states, with benefits for social interaction. Finally, because emotions can be expressed in various modalities, we examine the multimodal integration of dynamic and static cues across different channels, and conclude with suggestions for future research
Predictive signature of static and dynamic functional connectivity for ECT clinical outcomes
Introduction: Electroconvulsive therapy (ECT) remains one of the most effective approaches for treatment-resistant depressive episodes, despite the potential cognitive impairment associated with this treatment. As a potent stimulator of neuroplasticity, ECT might normalize aberrant depression-related brain function via the brain’s reconstruction by forming new neural connections. Multiple lines of evidence have demonstrated that functional connectivity (FC) changes are reliable indicators of antidepressant efficacy and cognitive changes from static and dynamic perspectives. However, no previous studies have directly ascertained whether and how different aspects of FC provide complementary information in terms of neuroimaging-based prediction of clinical outcomes.Methods: In this study, we implemented a fully automated independent component analysis framework to an ECT dataset with subjects (n = 50, age = 65.54 ± 8.92) randomized to three treatment amplitudes (600, 700, or 800 milliamperes [mA]). We extracted the static functional network connectivity (sFNC) and dynamic FNC (dFNC) features and employed a partial least square regression to build predictive models for antidepressant outcomes and cognitive changes.Results: We found that both antidepressant outcomes and memory changes can be robustly predicted by the changes in sFNC (permutation test p < 5.0 × 10−3). More interestingly, by adding dFNC information, the model achieved higher accuracy for predicting changes in the Hamilton Depression Rating Scale 24-item (HDRS24, t = 9.6434, p = 1.5 × 10−21). The predictive maps of clinical outcomes show a weakly negative correlation, indicating that the ECT-induced antidepressant outcomes and cognitive changes might be associated with different functional brain neuroplasticity.Discussion: The overall results reveal that dynamic FC is not redundant but reflects mechanisms of ECT that cannot be captured by its static counterpart, especially for the prediction of antidepressant efficacy. Tracking the predictive signatures of static and dynamic FC will help maximize antidepressant outcomes and cognitive safety with individualized ECT dosing
Hidden Strains: Understanding Schizophrenia's Impact on Families and Communities
"Hidden Strains: Understanding Schizophrenia's Impact on Families and Communities" examines the challenges family caregivers of schizophrenia patients face in Romania. This study uncovers the socio-economic burdens and limited psychiatric support, particularly in rural areas, compounded by societal stigma. A significant finding is the caregivers' knowledge gap about schizophrenia, underscoring the need for mental health education for early detection and stigma reduction. The research stresses the vital roles of family and community in schizophrenia care, advocating for more community resources. It introduces innovative care models like the "Open Dialogue Approach" from Scandinavia, suggesting solutions for Romania's mental health challenges. Broadening its view, "Hidden Strains" contrasts Romanian mental health issues with global trends, emphasizing the urgency of mental health reforms. Concluding with recommendations for worldwide application, this work offers insights for professionals, caregivers, and policymakers, and resonates universally despite its Romanian foundation
Enhancing autobiographical memory fluency & specificity: effects of eye movements & eye closure
Research has demonstrated that performing a sequence of saccadic horizontal eye movements (SEMs) prior to retrieval or closing one’s eyes during retrieval facilitates episodic memory. The research in this thesis is concerned with increasing the recall of episodic autobiographical memory in old (Experiment 1) and younger (Experiment 1-3) individuals with the use SEMs (Experiments 1-3) and eye-closure (Experiments 2-3).
Experiment 1 extends previous research by examining the effects of SEMs in older and younger adults. Autobiographical episodic and semantic memory fluency was assessed in younger and older participants following saccadic (vs. fixation control) manipulations. Eye movements enhanced episodic fluency in both age groups. Semantic autobiographical memory showed a main effect of age (greater fluency in younger participants), whereas general semantic memory showed no effect of age or eye movement.
Experiment 2 extended the first study by the inclusion of eye-closure. The experiment also changed how memories were elicited by use of the Galton Crovitz technique using concrete and abstract words. Recall was measured by the specificity of recall and its associated phenomenological qualities. The experiment found concrete cues to enhance both the specificity of recall and phenomenological qualities. Eye movements increased memory specificity but not phenomenological qualities. Eye closure effects were only found on the phenomenological qualities of ‘seeing’ and ‘hearing’.
Experiment 3 made changes to both manipulations and measurements. Eye-closure was altered from between to within subjects and dynamic visual noise (DVN) was included to increase distraction with eyes open. As before, SEMs was manipulated between-subjects. Regarding measurements, participants indicated whether memories were recalled directly or after more effortful generation. A significant effect of eye-closure/distraction was found (except direct vs generative recall which only showed effects of DVN) showing an advantage in the eye closure condition. Cue-type produced similar findings to Experiment 2 but SEM effects produced only numerical differences. This is the first-time eye-closure and DVN effects have been shown in autobiographical memory using the cue-word technique
Pediatric and Adolescent Nephrology Facing the Future: Diagnostic Advances and Prognostic Biomarkers in Everyday Practice
The Special Issue entitled “Pediatric and adolescent nephrology facing the future: diagnostic advances and prognostic biomarkers in everyday practice” contains articles written in the era when COVID-19 had not yet been a major clinical problem in children. Now that we know its multifaceted clinical course, complications concerning the kidneys, and childhood-specific post-COVID pediatric inflammatory multisystem syndrome (PIMS), the value of diagnostic and prognostic biomarkers in the pediatric area should be appreciated, and their importance ought to increase
Internet and Biometric Web Based Business Management Decision Support
Internet and Biometric Web Based Business Management Decision Support
MICROBE
MOOC material prepared under
IO1/A5 Development of the MICROBE personalized MOOCs content and teaching materials
Prepared by:
A. Kaklauskas, A. Banaitis, I. Ubarte
Vilnius Gediminas Technical University, Lithuania
Project No: 2020-1-LT01-KA203-07810
Human Connection as a Treatment for Addiction
Research supports that social connection is important in both humans and animals. In humans, having a cohesive support/social network system and healthy attachments in childhood predict low risk of later addiction (i.e. substance use disorder), as does perceived support from a religious or other cohesive community. Moreover, personal characteristics such as identifying as religious or spiritual can predict low risk for addiction, but little is known about the intersection of neuroscience and religion/spirituality in this regard. Conversely, adverse childhood experiences (ACEs) have repeatedly been shown to predict later addiction. However, the role of the body’s neuro-hormonal responses, such as the endogenous opioid and oxytocin systems in this process merits further exploration, such as how the production or deprivation of endogenous opioids impact later substance use patterns. Existing research also provides evidence that individuals decrease pursuit of interpersonal connections and social bonds when they use substances that activate opioid receptors. This has been found with both substances of abuse and medications used to treat addiction (e.g., methadone, buprenorphine, naltrexone). Research has also demonstrated that addiction often results in situations of social isolation. However, it remains to be elucidated whether the substances of abuse physiologically meet that need for connection. Importantly, research across numerous fields indicates that intentionally increasing interpersonal connection may be an effective treatment for addiction. However, less is known about how specific characteristics of communities impact the quantity, quality, or effectiveness of care and support for a person with addiction [...]https://dc.etsu.edu/etsu_books/1292/thumbnail.jp
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