Towards Accurate Dielectric Property Retrieval of Biological Tissues for Blood Glucose Monitoring

(c) 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.This post-acceptance version of the paper is essentially complete, but may differ from the official copy of record, which can be found at the following web location (subscription required to access full paper): http://dx.doi.org/10/1109/TMTT.2014.2365019

Smartphone-Based pH Sensor for Home Monitoring of Pulmonary Exacerbations in Cystic Fibrosis.

Currently, Cystic Fibrosis (CF) patients lack the ability to track their lung health at home, relying instead on doctor checkups leading to delayed treatment and lung damage. By leveraging the ubiquity of the smartphone to lower costs and increase portability, a smartphone-based peripheral pH measurement device was designed to attach directly to the headphone port to harvest power and communicate with a smartphone application. This platform was tested using prepared pH buffers and sputum samples from CF patients. The system matches within ~0.03 pH of a benchtop pH meter while fully powering itself and communicating with a Samsung Galaxy S3 smartphone paired with either a glass or Iridium Oxide (IrOx) electrode. The IrOx electrodes were found to have 25% higher sensitivity than the glass probes at the expense of larger drift and matrix sensitivity that can be addressed with proper calibration. The smartphone-based platform has been demonstrated as a portable replacement for laboratory pH meters, and supports both highly robust glass probes and the sensitive and miniature IrOx electrodes with calibration. This tool can enable more frequent pH sputum tracking for CF patients to help detect the onset of pulmonary exacerbation to provide timely and appropriate treatment before serious damage occurs

Design of a CMOS closed-loop system with applications to bio-impedance measurements

This paper proposes a method for impedance measurements based on a closed-loop implementation of CMOS circuits. The proposed system has been conceived for alternate current excited systems, performing simultaneously driving and measuring functions, thanks to feedback. The system delivers magnitude and phase signals independently, which can be optimized separately, and can be applied to any kind of load (resistive and capacitive). Design specifications for CMOS circuit blocks and trade-offs for system accuracy and loop stability have been derived. Electrical simulation results obtained for several loads agree with the theory, enabling the proposed method to any impedance measurement problem, in special, to bio-setups including electrodes.Ministerio de Ciencia e Innovación TEC2007-6807

Design and development of a novel Invasive Blood Pressure simulator for patient's monitor testing

This paper presents a newly-designed and realized Invasive Blood Pressure (IBP) device for the simulation on patient’s monitors. This device shows improvements and presents extended features with respect to a first prototype presented by the authors and similar systems available in the state-of-the-art. A peculiarity of the presented device is that all implemented features can be customized from the developer and from the point of view of the end user. The realized device has been tested, and its performances in terms of accuracy and of the back-loop measurement of the output for the blood pressure regulation utilization have been described. In particular, an accuracy of ±1 mmHg at 25 °C, on a range from −30 to 300 mmHg, was evaluated under different test conditions. The designed device is an ideal tool for testing IBP modules, for zero setting, and for calibrations. The implemented extended features, like the generation of custom waveforms and the Universal Serial Bus (USB) connectivity, allow use of this device in a wide range of applications, from research to equipment maintenance in clinical environments to educational purposes. Moreover, the presented device represents an innovation, both in terms of technology and methodologies: It allows quick and efficient tests to verify the proper functioning of IBP module of patients’ monitors. With this innovative device, tests can be performed directly in the field and faster procedures can be implemented by the clinical maintenance personnel. This device is an open source project and all materials, hardware, and software are fully available for interested developers or researchers.Web of Science201art. no. 25

Electrical properties of breast cancer cells from impedance measurement of cell suspensions

Impedance spectroscopy of biological cells has been used to monitor cell status, e.g. cell proliferation, viability, etc. It is also a fundamental method for the study of the electrical properties of cells which has been utilised for cell identification in investigations of cell behaviour in the presence of an applied electric field, e.g. electroporation. There are two standard methods for impedance measurement on cells. The use of microelectrodes for single cell impedance measurement is one method to realise the measurement, but the variations between individual cells introduce significant measurement errors. Another method to measure electrical properties is by the measurement of cell suspensions, i.e. a group of cells within a culture medium or buffer. This paper presents an investigation of the impedance of normal and cancerous breast cells in suspension using the Maxwell-Wagner mixture theory to analyse the results and extract the electrical parameters of a single cell. The results show that normal and different stages of cancer breast cells can be distinguished by the conductivity presented by each cell. © 2010 IOP Publishing Ltd

Study directed at development of an implantable biotelemetry ion detector

A literature search was conducted to currently update known information in the field of ion-selective electrodes. The review attempts to identify present trends in cation and anions selective electrodes pertinent to the area of bioimplantable units. An electronic circuit was designed to provide the high impedance interface between the ion-selective sensors and signal-processing equipment. The resulting design emphasized the need for low power and miniaturization. Many of the circuits were constructed and used to evaluate the ion-selective electrodes. A cuvette capable of holding the ion-selective and the reference electrodes was designed and constructed. This equipment was used to evaluate commercially available ion-selective electrodes and the electrodes designed and constructed in the study. The results of the electrode tests are included

Magnetic and electric field meters developed for the US Department of Energy

This report describes work done at the Jet Propulsion Laboratory for the Office of Energy Storage and Distribution of DOE on the measurement of power line fields. A magnetic field meter is discussed that uses fiber optics to couple a small measuring probe to a remote readout device. The use of fiber optics minimizes electric field perturbation due to the presence of the probe and provides electric isolation for the probe, so that it could be used in a high field or high voltage environment. Power to operate the sensor electronics is transferred via an optical fiber, and converted to electrical form by a small photodiode array. The fundamental, the second and third harmonics of the field are filtered and separately measured, as well as the broadband rms level of the field. The design of the meter is described in detail and data from laboratory tests are presented. The report also describes work done to improve the performance of a DC bushing in a Swedish factory, using the improved meter. The DC electric fields are measured with synchronous detection to provide field magnitude data in two component directions