The Parallelism Motifs of Genomic Data Analysis

Genomic data sets are growing dramatically as the cost of sequencing continues to decline and small sequencing devices become available. Enormous community databases store and share this data with the research community, but some of these genomic data analysis problems require large scale computational platforms to meet both the memory and computational requirements. These applications differ from scientific simulations that dominate the workload on high end parallel systems today and place different requirements on programming support, software libraries, and parallel architectural design. For example, they involve irregular communication patterns such as asynchronous updates to shared data structures. We consider several problems in high performance genomics analysis, including alignment, profiling, clustering, and assembly for both single genomes and metagenomes. We identify some of the common computational patterns or motifs that help inform parallelization strategies and compare our motifs to some of the established lists, arguing that at least two key patterns, sorting and hashing, are missing

Mixing multi-core CPUs and GPUs for scientific simulation software

Recent technological and economic developments have led to widespread availability of multi-core CPUs and specialist accelerator processors such as graphical processing units (GPUs). The accelerated computational performance possible from these devices can be very high for some applications paradigms. Software languages and systems such as NVIDIA's CUDA and Khronos consortium's open compute language (OpenCL) support a number of individual parallel application programming paradigms. To scale up the performance of some complex systems simulations, a hybrid of multi-core CPUs for coarse-grained parallelism and very many core GPUs for data parallelism is necessary. We describe our use of hybrid applica- tions using threading approaches and multi-core CPUs to control independent GPU devices. We present speed-up data and discuss multi-threading software issues for the applications level programmer and o er some suggested areas for language development and integration between coarse-grained and ne-grained multi-thread systems. We discuss results from three common simulation algorithmic areas including: partial di erential equations; graph cluster metric calculations and random number generation. We report on programming experiences and selected performance for these algorithms on: single and multiple GPUs; multi-core CPUs; a CellBE; and using OpenCL. We discuss programmer usability issues and the outlook and trends in multi-core programming for scienti c applications developers

Parallel computing in information retrieval - An updated review

The progress of parallel computing in Information Retrieval (IR) is reviewed. In particular we stress the importance of the motivation in using parallel computing for Text Retrieval. We analyse parallel IR systems using a classification due to Rasmussen [1] and describe some parallel IR systems. We give a description of the retrieval models used in parallel Information Processing.. We describe areas of research which we believe are needed

Mapping of portable parallel programs

An efficient parallel program designed for a parallel architecture includes a detailed outline of accurate assignments of concurrent computations onto processors, and data transfers onto communication links, such that the overall execution time is minimized. This process may be complex depending on the application task and the target multiprocessor architecture. Furthermore, this process is to be repeated for every different architecture even though the application task may be the same. Consequently, this has a major impact on the ever increasing cost of software development for multiprocessor systems. A remedy for this problem would be to design portable parallel programs which can be mapped efficiently onto any computer system. In this dissertation, we present a portable programming tool called Cluster-M. The three components of Cluster-M are the Specification Module, the Representation Module, and the Mapping Module. In the Specification Module, for a given problem, a machine-independent program is generated and represented in the form of a clustered task graph called Spec graph. Similarly, in the Representation Module, for a given architecture or heterogeneous suite of computers, a clustered system graph called Rep graph is generated. The Mapping Module is responsible for efficient mapping of Spec graphs onto Rep graphs. As part of this module, we present the first algorithm which produces a near-optimal mapping of an arbitrary non-uniform machine-independent task graph with M modules, onto an arbitrary non-uniform task-independent system graph having N processors, in 0(M P) time, where P = max(M, N). Our experimental results indicate that Cluster-M produces better or similar mapping results compared to other leading techniques which work only for restricted task or system graphs

Theory and design of portable parallel programs for heterogeneous computing systems and networks

A recurring problem with high-performance computing is that advanced architectures generally achieve only a small fraction of their peak performance on many portions of real applications sets. The Amdahl\u27s law corollary of this is that such architectures often spend most of their time on tasks (codes/algorithms and the data sets upon which they operate) for which they are unsuited. Heterogeneous Computing (HC) is needed in the mid 90\u27s and beyond due to ever increasing super-speed requirements and the number of projects with these requirements. HC is defined as a special form of parallel and distributed computing that performs computations using a single autonomous computer operating in both SIMD and MIMD modes, or using a number of connected autonomous computers. Physical implementation of a heterogeneous network or system is currently possible due to the existing technological advances in networking and supercomputing. Unfortunately, software solutions for heterogeneous computing are still in their infancy. Theoretical models, software tools, and intelligent resource-management schemes need to be developed to support heterogeneous computing efficiently. In this thesis, we present a heterogeneous model of computation which encapsulates all the essential parameters for designing efficient software and hardware for HC. We also study a portable parallel programming tool, called Cluster-M, which implements this model. Furthermore, we study and analyze the hardware and software requirements of HC and show that, Cluster-M satisfies the requirements of HC environments

An Application Perspective on High-Performance Computing and Communications

We review possible and probable industrial applications of HPCC focusing on the software and hardware issues. Thirty-three separate categories are illustrated by detailed descriptions of five areas -- computational chemistry; Monte Carlo methods from physics to economics; manufacturing; and computational fluid dynamics; command and control; or crisis management; and multimedia services to client computers and settop boxes. The hardware varies from tightly-coupled parallel supercomputers to heterogeneous distributed systems. The software models span HPF and data parallelism, to distributed information systems and object/data flow parallelism on the Web. We find that in each case, it is reasonably clear that HPCC works in principle, and postulate that this knowledge can be used in a new generation of software infrastructure based on the WebWindows approach, and discussed in an accompanying paper

Parallelisation of EST clustering

Master of Science - ScienceThe field of bioinformatics has been developing steadily, with computational problems related to biology taking on an increased importance as further advances are sought. The large data sets involved in problems within computational biology have dictated a search for good, fast approximations to computationally complex problems. This research aims to improve a method used to discover and understand genes, which are small subsequences of DNA. A difficulty arises because genes contain parts we know to be functional and other parts we assume are non-functional as there functions have not been determined. Isolating the functional parts requires the use of natural biological processes which perform this separation. However, these processes cannot read long sequences, forcing biologists to break a long sequence into a large number of small sequences, then reading these. This creates the computational difficulty of categorizing the short fragments according to gene membership. Expressed Sequence Tag Clustering is a technique used to facilitate the identification of expressed genes by grouping together similar fragments with the assumption that they belong to the same gene. The aim of this research was to investigate the usefulness of distributed memory parallelisation for the Expressed Sequence Tag Clustering problem. This was investigated empirically, with a distributed system tested for speed against a sequential one. It was found that distributed memory parallelisation can be very effective in this domain. The results showed a super-linear speedup for up to 100 processors, with higher numbers not tested, and likely to produce further speedups. The system was able to cluster 500000 ESTs in 641 minutes using 101 processors

Automatic visual recognition using parallel machines

Invariant features and quick matching algorithms are two major concerns in the area of automatic visual recognition. The former reduces the size of an established model database, and the latter shortens the computation time. This dissertation, will discussed both line invariants under perspective projection and parallel implementation of a dynamic programming technique for shape recognition. The feasibility of using parallel machines can be demonstrated through the dramatically reduced time complexity. In this dissertation, our algorithms are implemented on the AP1000 MIMD parallel machines. For processing an object with a features, the time complexity of the proposed parallel algorithm is O(n), while that of a uniprocessor is O(n2). The two applications, one for shape matching and the other for chain-code extraction, are used in order to demonstrate the usefulness of our methods. Invariants from four general lines under perspective projection are also discussed in here. In contrast to the approach which uses the epipolar geometry, we investigate the invariants under isotropy subgroups. Theoretically speaking, two independent invariants can be found for four general lines in 3D space. In practice, we show how to obtain these two invariants from the projective images of four general lines without the need of camera calibration. A projective invariant recognition system based on a hypothesis-generation-testing scheme is run on the hypercube parallel architecture. Object recognition is achieved by matching the scene projective invariants to the model projective invariants, called transfer. Then a hypothesis-generation-testing scheme is implemented on the hypercube parallel architecture