An Unsupervised Learning Model for Deformable Medical Image Registration

We present a fast learning-based algorithm for deformable, pairwise 3D medical image registration. Current registration methods optimize an objective function independently for each pair of images, which can be time-consuming for large data. We define registration as a parametric function, and optimize its parameters given a set of images from a collection of interest. Given a new pair of scans, we can quickly compute a registration field by directly evaluating the function using the learned parameters. We model this function using a convolutional neural network (CNN), and use a spatial transform layer to reconstruct one image from another while imposing smoothness constraints on the registration field. The proposed method does not require supervised information such as ground truth registration fields or anatomical landmarks. We demonstrate registration accuracy comparable to state-of-the-art 3D image registration, while operating orders of magnitude faster in practice. Our method promises to significantly speed up medical image analysis and processing pipelines, while facilitating novel directions in learning-based registration and its applications. Our code is available at https://github.com/balakg/voxelmorph .Comment: 9 pages, in CVPR 201

Efficient Continuous-Time SLAM for 3D Lidar-Based Online Mapping

Modern 3D laser-range scanners have a high data rate, making online simultaneous localization and mapping (SLAM) computationally challenging. Recursive state estimation techniques are efficient but commit to a state estimate immediately after a new scan is made, which may lead to misalignments of measurements. We present a 3D SLAM approach that allows for refining alignments during online mapping. Our method is based on efficient local mapping and a hierarchical optimization back-end. Measurements of a 3D laser scanner are aggregated in local multiresolution maps by means of surfel-based registration. The local maps are used in a multi-level graph for allocentric mapping and localization. In order to incorporate corrections when refining the alignment, the individual 3D scans in the local map are modeled as a sub-graph and graph optimization is performed to account for drift and misalignments in the local maps. Furthermore, in each sub-graph, a continuous-time representation of the sensor trajectory allows to correct measurements between scan poses. We evaluate our approach in multiple experiments by showing qualitative results. Furthermore, we quantify the map quality by an entropy-based measure.Comment: In: Proceedings of the International Conference on Robotics and Automation (ICRA) 201

A Statistical Model for Simultaneous Template Estimation, Bias Correction, and Registration of 3D Brain Images

Template estimation plays a crucial role in computational anatomy since it provides reference frames for performing statistical analysis of the underlying anatomical population variability. While building models for template estimation, variability in sites and image acquisition protocols need to be accounted for. To account for such variability, we propose a generative template estimation model that makes simultaneous inference of both bias fields in individual images, deformations for image registration, and variance hyperparameters. In contrast, existing maximum a posterori based methods need to rely on either bias-invariant similarity measures or robust image normalization. Results on synthetic and real brain MRI images demonstrate the capability of the model to capture heterogeneity in intensities and provide a reliable template estimation from registration