3,024 research outputs found
Consensus, Cohesion and Connectivity
Social life clusters into groups held together by ties that also transmit
information. When collective problems occur, group members use their ties to
discuss what to do and to establish an agreement, to be reached quick enough to
prevent discounting the value of the group decision. The speed at which a group
reaches consensus can be predicted by the algebraic connectivity of the
network, which also imposes a lower bound on the group's cohesion. This
specific measure of connectivity is put to the test by re-using experimental
data, which confirm the prediction
Influence of Demographic Patterns on Human Response to Exposure to Environmental Contaminants: Heterogeneity Factors
It is generally accepted that the risk of disease and death vary markedly by age and sex. However, there are also inherited and acquired factors that cause vast differences in human susceptibility to many pollutant exposures. Most people are less familiar with this wide range of heterogeneity precipitated by genetic make-up, life style, occupation, nutrition, residence location, etc.
The combined role of these many heterogeneity factors is often underestimated. Yet they are the major factors that determine the evolution of mortality and morbidity patterns within a population.
In this paper, we examine a variety of heterogeneities present in environmental pollutant susceptibilities, briefly look at how attempts to recognize heterogeneity have played a role in efforts to regulate pollutants, consider how likely shifts in the composition of population may affect morbidity and mortality rates affected by environmental pollution, discuss how indirect heterogeneity factors can lead to additional complications in interpretations of pollution-related mortality statistics, and offer several suggestive models of heterogeneous susceptibility
Enhancing Bayesian risk prediction for epidemics using contact tracing
Contact tracing data collected from disease outbreaks has received relatively
little attention in the epidemic modelling literature because it is thought to
be unreliable: infection sources might be wrongly attributed, or data might be
missing due to resource contraints in the questionnaire exercise. Nevertheless,
these data might provide a rich source of information on disease transmission
rate. This paper presents novel methodology for combining contact tracing data
with rate-based contact network data to improve posterior precision, and
therefore predictive accuracy. We present an advancement in Bayesian inference
for epidemics that assimilates these data, and is robust to partial contact
tracing. Using a simulation study based on the British poultry industry, we
show how the presence of contact tracing data improves posterior predictive
accuracy, and can directly inform a more effective control strategy.Comment: 40 pages, 9 figures. Submitted to Biostatistic
Constraint satisfaction mechanisms for marginal stability and criticality in large ecosystems
We discuss a resource-competition model, which takes the MacArthur's model as
a platform, to unveil interesting connections with glassy features and jamming
in high dimension. This model presents two qualitatively different phases: a
"shielded" phase, where a collective and self-sustained behavior emerges, and a
"vulnerable" phase, where a small perturbation can destabilize the system and
contribute to population extinction. We first present our perspective based on
a strong similarity with continuous constraint satisfaction problems in their
convex regime. Then, we discuss the stability in terms of the computation of
the leading eigenvalue of the Hessian matrix of the free energy in the replica
space. This computation allows us to efficiently distinguish between the two
aforementioned phases and to relate high-dimensional critical ecosystems to
glassy phenomena in the low-temperature regime.Comment: Updated version with references added. 6 pages, 2 figure
Novel Multidimensional Models of Opinion Dynamics in Social Networks
Unlike many complex networks studied in the literature, social networks
rarely exhibit unanimous behavior, or consensus. This requires a development of
mathematical models that are sufficiently simple to be examined and capture, at
the same time, the complex behavior of real social groups, where opinions and
actions related to them may form clusters of different size. One such model,
proposed by Friedkin and Johnsen, extends the idea of conventional consensus
algorithm (also referred to as the iterative opinion pooling) to take into
account the actors' prejudices, caused by some exogenous factors and leading to
disagreement in the final opinions.
In this paper, we offer a novel multidimensional extension, describing the
evolution of the agents' opinions on several topics. Unlike the existing
models, these topics are interdependent, and hence the opinions being formed on
these topics are also mutually dependent. We rigorous examine stability
properties of the proposed model, in particular, convergence of the agents'
opinions. Although our model assumes synchronous communication among the
agents, we show that the same final opinions may be reached "on average" via
asynchronous gossip-based protocols.Comment: Accepted by IEEE Transaction on Automatic Control (to be published in
May 2017
Vaccine Effects on Heterogeneity in Susceptibility and Implications for Population Health Management
Heterogeneity in host susceptibility is a key determinant of infectious disease dynamics but is rarely accounted for in assessment of disease control measures. Understanding how susceptibility is distributed in populations, and how control measures change this distribution, is integral to predicting the course of epidemics with and without interventions. Using multiple experimental and modeling approaches, we show that rainbow trout have relatively homogeneous susceptibility to infection with infectious hematopoietic necrosis virus and that vaccination increases heterogeneity in susceptibility in a nearly all-or-nothing fashion. In a simple transmission model with an R-0 of 2, the highly heterogeneous vaccine protection would cause a 35 percentage-point reduction in outbreak size over an intervention inducing homogenous protection at the same mean level. More broadly, these findings provide validation of methodology that can help to reduce biases in predictions of vaccine impact in natural settings and provide insight into how vaccination shapes population susceptibility. IMPORTANCE Differences among individuals influence transmission and spread of infectious diseases as well as the effectiveness of control measures. Control measures, such as vaccines, may provide leaky protection, protecting all hosts to an identical degree, or all-or-nothing protection, protecting some hosts completely while leaving others completely unprotected. This distinction can have a dramatic influence on disease dynamics, yet this distribution of protection is frequently unaccounted for in epidemiological models and estimates of vaccine efficacy. Here, we apply new methodology to experimentally examine host heterogeneity in susceptibility and mode of vaccine action as distinct components influencing disease outcome. Through multiple experiments and new modeling approaches, we show that the distribution of vaccine effects can be robustly estimated. These results offer new experimental and inferential methodology that can improve predictions of vaccine effectiveness and have broad applicability to human, wildlife, and ecosystem health
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