Aerospace medicine and biology: A continuing bibliography with indexes (supplement 335)

This bibliography lists 143 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during March, 1990. Subject coverage includes: aerospace medicine and psychology, life support systems and controlled environments, safety equipment, exobiology and extraterrestrial life, and flight crew behavior and performance

EFFICACY OF AUTOMATED WIRELESS HEARING TEST SYSTEM IMPLEMENTED IN AN EXERCISE-BASED CANCER REHABILITATION PROGRAM

Cancer patients are at risk of hearing loss due to the ototoxicity of chemotherapeutics and radiation treatments. Gaining clinical access to ototoxic monitoring is a challenge for patients, and physicians are often hesitant to burden their patients with more travel and appointment scheduling to obtain hearing testing. The current pilot study evaluated the feasibility of utilizing the newly developed Creare Wireless Automated Hearing Test System (WAHTS) in an exercise-based cancer rehabilitation center setting. Nine cancer patients were recruited for hearing testing. Hearing tests were conducted using an automated testing algorithm (WAHTS) in an open room and then tested again using manual audiometry conducted in a clinical sound booth test environment. Statistical analysis (t-test) revealed no significant difference between the hearing tests conducted in an open room in the exercise center and those conducted in the clinical setting (p\u3e.05). Future research is needed to investigate the implementation of the WAHTS as a means of monitoring cancer patients for ototoxicity while receiving chemotherapeutics or radiation treatments and simultaneously participating in an exercise-based cancer rehabilitation program

A comparative analysis of haptic and EEG devices for evaluation and training of post-stroke patients within a virtual environment

Virtual Rehabilitation benefits from the usage of interfaces other than the mouse and keyboard, but also possess disadvantages: haptic peripherals can utilize the subject\u27s hand to provide position information or joint angles, and allow direct training for specific movements; but can also place unneeded strain on the limbs; brain-machine interfaces (BMI) can provide direct connections from the user to external hardware or software, but are currently inaccurate for the full diversity of user movements in daily life and require invasive surgery to implement. A compromise between these two extremes is a BMI that can be adapted to specific users, can function with a wide range of hardware and software, and is both noninvasive and convenient to wear for extended periods of time. A suitable BMI using Electroencephalography (EEG) input, known as the Emotiv EPOC™ by Emotiv Systems was evaluated using multiple input specializations and tested with an external robotic arm to determine if it was suitable for control of peripherals. Users were given a preset periodicity to follow in order to evaluate their ability to translate specific facial movements into commands as well as their responsiveness to change the robot arm\u27s direction. Within 2 weeks of training, they maintained or improved axial control of the robot arm, and reduced their overall performance time. Although the EPOC™ does require further testing and development, its adaptability to multiple software programs, users and peripherals allows it to serve both Virtual Rehabilitation and device control in the immediate future

Technology applications

A summary of NASA Technology Utilization programs for the period of 1 December 1971 through 31 May 1972 is presented. An abbreviated description of the overall Technology Utilization Applications Program is provided as a background for the specific applications examples. Subjects discussed are in the broad headings of: (1) cancer, (2) cardiovascular disease, (2) medical instrumentation, (4) urinary system disorders, (5) rehabilitation medicine, (6) air and water pollution, (7) housing and urban construction, (8) fire safety, (9) law enforcement and criminalistics, (10) transportation, and (11) mine safety

Evaluating the Clinical Utility of a Novel Electroencephalography System for Assessing Perioperative Neurocognition in Older Surgical Patients

Postoperative delirium (POD) is a public health and research priority (American Society of Anesthesiologists, 2019). POD is a risk factor for long-term neurocognitive decline, and the rate of decline is directly proportional to the severity of POD (Vasunilashorn et al., 2018). Baseline cognitive function is a strong, independent predictor for POD (Culley et al., 2017). The International Perioperative Neurotoxicity Working Group recommends baseline cognitive function be assessed for older patients prior to surgery and anesthesia (Berger, et al., 2018). Perioperative cognitive screening tools trialed in anesthesia are not routinely incorporated into clinical practice related to validity, reliability, or practicality problems (Berger, et al., 2018). The ideal perioperative cognitive screening tool would be rapid, easily-administrable, valid, reliable, automatically scored, void of language, cultural, and education bias and cost-efficient (Axley & Schenning, 2015). No such tool has been identified to date. This study, guided by Donabedian’s theoretical model, evaluated the utility of a novel point-of-care (POC) electroencephalography (EEG) system, WAVi MedicalTM (Boulder, CO), for the perioperative neurocognitive assessment of older surgical patients. This study conducted a secondary analysis of data from the “Perioperative Brain Health” – IRB HM20019839 study. The “Perioperative Brain Health” study is an ongoing study collecting both pre- and postoperative questionnaire-based neurocognitive assessments alongside WAVi-derived P300 auditory evoked potentials. Data was analyzed using regression and analysis of variance. The WAVi MedicalTM system may one day offer anesthesia providers a novel neurocognitive assessment tool for predicting, identifying, and tracking perioperative neurocognitive disorders in older surgical patients

Creating a Safer Running Experience: Reducing Runner and Vehicular Traffic Incidents

A routine run can turn into a final run in a matter of seconds. Runners and drivers are exposed to a variety of distractions that hinder their ability to safely react to potential incidents. With the help of Augmented Reality and wearable technology, runners can help reduce traffic related incidents by staying focused on the road and their surroundings. This project looks to investigate how AR technology can be leveraged to offer the safest run without diminishing the running user-experience

Neural correlates of verbal feedback processing: an fMRI study employing overt speech

Speakers use external auditory feedback to monitor their own speech. Feedback distortion has been found to increase activity in the superior temporal areas. Using fMRI, the present study investigates the neural correlates of processing verbal feedback without distortion. In a blocked design, the following conditions were presented: (1) overt picture-naming, (2) overt picture-naming while pink noise was presented to mask external feedback, (3) covert picture-naming, (4) listening to the picture names (previously recorded from participants' own voices), and (5) listening to pink noise. The results show that auditory feedback processing involves a network of different areas related to general performance monitoring and speech-motor control. These include the cingulate cortex and the bilateral insula, supplementary motor area, bilateral motor areas, cerebellum, thalamus and basal ganglia. Our findings suggest that the anterior cingulate cortex, which is often implicated in error-processing and conflict-monitoring, is also engaged in ongoing speech monitoring. Furthermore, in the superior temporal gyrus, we found a reduced response to speaking under normal feedback conditions. This finding is interpreted in the framework of a forward model according to which, during speech production, the sensory consequence of the speech-motor act is predicted to attenuate the sensitivity of the auditory cortex. Hum Brain Mapp 2007. © 2007 Wiley-Liss, Inc

Cardiac Regeneration and Disease Modeling Using Biomaterial-Free Three-Dimensional (3D) Bioprinted Cardiac Tissue

Biomaterial-free 3D bioprinting is a relatively new field within 3D bioprinting. In this implementation, 3D tissues are created from the fusion of 3D multicellular spheroids, without requiring biomaterials. This is in contrast to traditional 3D bioprinting, which requires biomaterials to carry the cells to be bioprinted, such as a hydrogel or decellularized extracellular matrix. In this dissertation, we discuss the generation of biomaterial-free 3D cardiac spheroids and 3D bioprinted cardiac patches, their mechanical, electrical and biological functional characterization in vitro and in vivo for cardiac regeneration. Additionally, we investigated their potential use as a disease model using congenital long QT syndrome due to an inherited calmodulinopathy as an example, utilizing CRISPR interference to shorten abnormally prolonged cardiac action potentials. At the same time, we demonstrate the use of virtual reality for the interactive visualization of cardiovascular structures and its potential use in pre-surgical planning and patient-specific precision medicine

Establishing a Framework for the development of Multimodal Virtual Reality Interfaces with Applicability in Education and Clinical Practice

The development of Virtual Reality (VR) and Augmented Reality (AR) content with multiple sources of both input and output has led to countless contributions in a great many number of fields, among which medicine and education. Nevertheless, the actual process of integrating the existing VR/AR media and subsequently setting it to purpose is yet a highly scattered and esoteric undertaking. Moreover, seldom do the architectures that derive from such ventures comprise haptic feedback in their implementation, which in turn deprives users from relying on one of the paramount aspects of human interaction, their sense of touch. Determined to circumvent these issues, the present dissertation proposes a centralized albeit modularized framework that thus enables the conception of multimodal VR/AR applications in a novel and straightforward manner. In order to accomplish this, the aforesaid framework makes use of a stereoscopic VR Head Mounted Display (HMD) from Oculus Rift©, a hand tracking controller from Leap Motion©, a custom-made VR mount that allows for the assemblage of the two preceding peripherals and a wearable device of our own design. The latter is a glove that encompasses two core modules in its innings, one that is able to convey haptic feedback to its wearer and another that deals with the non-intrusive acquisition, processing and registering of his/her Electrocardiogram (ECG), Electromyogram (EMG) and Electrodermal Activity (EDA). The software elements of the aforementioned features were all interfaced through Unity3D©, a powerful game engine whose popularity in academic and scientific endeavors is evermore increasing. Upon completion of our system, it was time to substantiate our initial claim with thoroughly developed experiences that would attest to its worth. With this premise in mind, we devised a comprehensive repository of interfaces, amid which three merit special consideration: Brain Connectivity Leap (BCL), Ode to Passive Haptic Learning (PHL) and a Surgical Simulator