96 research outputs found
A Case for using Grid Framework for Indian Rural Healthcare to Meet the Millennium Development Goals (MDGs)
As per the September 2010, Annual Report of Department of Health and Family Welfare, Ministry of Health and Family Welfare, GOI, 75% of human resources and advanced medical technology,70% of hospitals and 40% of beds are in the private sector and mostly in the urban areas. Due to poor Infrastructure, insufficient supply of skilled doctors and dispersed populations the people living in the rural areas do not get any specialist care ,advice and treatment plan resulting in high MMR (Maternal Mortality Rate per 100,000 live births) and IMR(Infant Mortality Rate).We have proposed a HealthGrid Framework using the SWAN as an IT backbone and also formation of a Data Grid EHR to be shared by specialist doctors to provide better medical services to the rural poor which in turn helps us to meet the MDGs by 2015
gcodeml: A Grid-enabled Tool for Detecting Positive Selection in Biological Evolution
One of the important questions in biological evolution is to know if certain
changes along protein coding genes have contributed to the adaptation of
species. This problem is known to be biologically complex and computationally
very expensive. It, therefore, requires efficient Grid or cluster solutions to
overcome the computational challenge. We have developed a Grid-enabled tool
(gcodeml) that relies on the PAML (codeml) package to help analyse large
phylogenetic datasets on both Grids and computational clusters. Although we
report on results for gcodeml, our approach is applicable and customisable to
related problems in biology or other scientific domains.Comment: 10 pages, 4 figures. To appear in the HealthGrid 2012 con
Technical support for Life Sciences communities on a production grid infrastructure
Production operation of large distributed computing infrastructures (DCI)
still requires a lot of human intervention to reach acceptable quality of
service. This may be achievable for scientific communities with solid IT
support, but it remains a show-stopper for others. Some application execution
environments are used to hide runtime technical issues from end users. But they
mostly aim at fault-tolerance rather than incident resolution, and their
operation still requires substantial manpower. A longer-term support activity
is thus needed to ensure sustained quality of service for Virtual Organisations
(VO). This paper describes how the biomed VO has addressed this challenge by
setting up a technical support team. Its organisation, tooling, daily tasks,
and procedures are described. Results are shown in terms of resource usage by
end users, amount of reported incidents, and developed software tools. Based on
our experience, we suggest ways to measure the impact of the technical support,
perspectives to decrease its human cost and make it more community-specific.Comment: HealthGrid'12, Amsterdam : Netherlands (2012
Improving knowledge management through the support of image examination and data annotation using DICOM structured reporting
[EN] An important effort has been invested on improving the image diagnosis process in different medical areas using information technologies. The field of medical imaging involves two main data types: medical imaging and reports. Developments based on the DICOM standard have demonstrated to be a convenient and widespread solution among the medical community. The main objective of this work is to design a Web application prototype that will be able to improve diagnosis and follow-on of breast cancer patients. It is based on TRENCADIS middleware, which provides a knowledge-oriented storage model composed by federated repositories of DICOM image studies and DICOM-SR medical reports. The full structure and contents of the diagnosis reports are used as metadata for indexing images. The TRENCADIS infrastructure takes full advantage of Grid technologies by deploying multi-resource grid services that enable multiple views (reports schemes) of the knowledge database. The paper presents a real deployment of such Web application prototype in the Dr. Peset Hospital providing radiologists with a tool to create, store and search diagnostic reports based on breast cancer explorations (mammography, magnetic resonance, ultrasound, pre-surgery biopsy and post-surgery biopsy), improving support for diagnostics decisions. A technical details for use cases (outlining enhanced multi-resource grid services communication and processing steps) and interactions between actors and the deployed prototype are described. As a result, information is more structured, the logic is clearer, network messages have been reduced and, in general, the system is more resistant to failures.The authors wish to thank the financial support received from The Spanish Ministry of Education and Science to develop the project "CodeCloud", with reference TIN2010-17804.Salavert Torres, J.; Segrelles Quilis, JD.; Blanquer Espert, I.; Hernández García, V. (2012). Improving knowledge management through the support of image examination and data annotation using DICOM structured reporting. Journal of Biomedical Informatics. 45(6):1066-1074. https://doi.org/10.1016/j.jbi.2012.07.004S1066107445
Synthesis, Characterization and Biological Activity of Quinoline Bound Imidazoles
8-Hydroxyqunoline derivatives were synthesised by treating 5-chloromethyl-8-hydroxy quinoline with imidazole and characterized using NMR and mass spectrometry. 2-mercaptoimidazole derivatives of 8-hydroxy quinoline were also synthesized and characterized. One of the compounds in this series has been tested for dengue activity along with other series of compounds, but did not show any activity against dengue virus
High Throughput Virtual Screening with Data Level Parallelism in Multi-core Processors
Improving the throughput of molecular docking, a computationally intensive
phase of the virtual screening process, is a highly sought area of research
since it has a significant weight in the drug designing process. With such
improvements, the world might find cures for incurable diseases like HIV
disease and Cancer sooner. Our approach presented in this paper is to utilize a
multi-core environment to introduce Data Level Parallelism (DLP) to the
Autodock Vina software, which is a widely used for molecular docking software.
Autodock Vina already exploits Instruction Level Parallelism (ILP) in
multi-core environments and therefore optimized for such environments. However,
with the results we have obtained, it can be clearly seen that our approach has
enhanced the throughput of the already optimized software by more than six
times. This will dramatically reduce the time consumed for the lead
identification phase in drug designing along with the shift in the processor
technology from multi-core to many-core of the current era. Therefore, we
believe that the contribution of this project will effectively make it possible
to expand the number of small molecules docked against a drug target and
improving the chances to design drugs for incurable diseases.Comment: Information and Automation for Sustainability (ICIAfS), 2012 IEEE 6th
International Conference o
A virtual imaging platform for multi-modality medical image simulation.
International audienceThis paper presents the Virtual Imaging Platform (VIP), a platform accessible at http://vip.creatis.insa-lyon.fr to facilitate the sharing of object models and medical image simulators, and to provide access to distributed computing and storage resources. A complete overview is presented, describing the ontologies designed to share models in a common repository, the workflow template used to integrate simulators, and the tools and strategies used to exploit computing and storage resources. Simulation results obtained in four image modalities and with different models show that VIP is versatile and robust enough to support large simulations. The platform currently has 200 registered users who consumed 33 years of CPU time in 2011
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