Dealing with Web service QoS factors using constraint hierarchy

Functionality and non-functional properties are two critical factors in web service technology, but non-functional properties (quality factors) are often ignored. Usually, these are articulated as statements of objectives, as opposed to prepositional assertions. A key challenge in dealing with objectives is that there is no obvious means to decide when they are satisfied. In effect, these objectives are never fu lly satisfied, but satisficed to varying degrees. Alternative design decisions need to trade-off varying degrees of satisfaction of potentially mutually contradictory non-functional requirements. In some circumstances, non-Junctional properties are crucial; they do affect the design decision. Upon a request, there are a range o f web services that might provide the required functionality, so the web service selection can only be done based on their Quality of Service (QoS). Therefore, a quality-based web service model is in high demand. The key contribution of this paper is the use of the hierarchical constraint logic programming framework [9, 10] in dealing with quality factors. We show how quality factors can be formulated as soft constraints and how the machinery associated with constraint hierarchies can be used to evaluate the web services

Our LIPS are sealed: interfacing logic and functional programming systems

technical reportWe report on a technique for interfacing an untyped logic language to a statically poly morphically typed functional language Our key insight is that polymorphic types can be interpreted as "need to know" specifications on function arguments. This leads to a criterion for liberally yet safely invoking the functional language to reduce application terms as required during unification in the logic language. This method called P unification enriches the capabilities of each language while retaining the integrity of their individual semantics and implementation technologies An experimental test has been successfully performed whereby a Horn clause logic programming (HCLP) interpreter written in Common Lisp was interfaced to the Standard ML of New Jersey system. The latter implementation was employed (i) on untyped or dynamically typed data, even though it is statically typed (ii) lazily, even though it is strict and (iii) on alien HCLP terms such as unbound variables - without the slightest modification

Study Abroad as a Multifaceted Approach to Supporting College Sophomores: Creating Optimal Environments to Promote Intercultural Maturity

Leaders in higher education bear the responsibility of creating educational environments and programming that promote student development and help prepare graduates to work, live, and lead in today\u27s interconnected and global society. Such institutional programming, which fosters intercultural maturity, defined as the cognitive, intrapersonal, and interpersonal developmental capacities that enable students to act in ways that are aware and appropriate, should be available to all students. Scholarly work, however, demonstrates that sophomore students receive the least amount of institutional attention and thus have fewer programs directed at fostering their development. As a result, sophomores can find themselves negotiating developmental challenges with little support or guidance. In an effort to explore the efficacy of one approach to providing developmental support for sophomores, this study examined the Second Year Experience Abroad program, one university\u27s attempt to re-engage sophomore students by fostering intercultural maturity. Specifically, the purpose of this mixed-methods explanatory sequential case study was to explore the relationship between study abroad programming and the extent to which it supports sophomore students by fostering intercultural maturity. Data collected using the Global Perspectives Inventory (GPI), a pre- and post-experience survey measuring the various capacities of intercultural maturity, revealed that sophomores experienced significant gains in awareness and understanding of various cultures and their impact on the global society (knowledge scale), and awareness and acceptance of the dimensions of their identity (identity scale). Regression analysis indicated that gender was associated with increases in almost all capacities related to intercultural maturity, where females experienced higher gains than their male counterparts. Interviews suggested that their experiences abroad influenced participants\u27 development of intercultural maturity to varying degrees, with more significant growth in the cognitive and intrapersonal domains. Cognitive gains included an increased understanding of the importance of cultural context when evaluating difference, while intrapersonal gains involved self-reflection in discovering identity. Taken together, this study contributes to the pre-existing knowledgebase surrounding study abroad programming and how promoting intercultural maturity might require a multifaceted approach when supporting sophomore students. Such findings may inform institutional policy and practice, serving as a model for designing innovative programs and solutions that promote intercultural maturity

The Experimental Reduction of Rock in a Camas Oven: Towards an Understanding of the Behavioral Significance of Fire-cracked Rock

The selection and management of rock for roasting ovens, hearths, and sweat lodges were not trivial concerns for prehistoric households. The results of replicating a camas roasting oven are used to address the use-life and use-stages of fire-cracked rock. We concluded that the industry associated with the procurement and management of fire-cracked rock in the Pacific Northwest required significant quantities of labor and expertise to manage the raw materials and camas roasting byproducts. Recording the technological performance characteristics of fire-cracked rocks, including composition, size, and durability, is a necessary step to interpret and compare fire-cracked rock features at archaeological sites

Discovery, Characterization, and Development of Small Molecule Inhibitors of Glycogen Synthase

Indiana University-Purdue University Indianapolis (IUPUI)The over-accumulation of glycogen appears as a hallmark in various glycogen storage diseases (GSDs), including Pompe, Cori, Andersen, and Lafora disease. Glycogen synthase (GS) is the rate-limiting enzyme for glycogen synthesis. Recent evidence suggests that suppression of glycogen accumulation represents a potential therapeutic approach for treating these diseases. Herein, we describe the discovery, characterization, and development of small molecule inhibitors of GS through a multicomponent study including biochemical, biophysical, and cellular assays. Adopting an affinity-based fluorescence polarization assay, we identified a substituted imidazole molecule (H23), as a first-in-class inhibitor of yeast glycogen synthase 2 (yGsy2) from the 50,000 ChemBridge DIVERSet library. Structural data derived from X-ray crystallography at 2.85 Å, and enzyme kinetic data, revealed that H23 bound within the uridine diphosphate glucose binding pocket of yGsy2. Medicinal chemistry efforts examining over 500 H23 analogs produced structure-activity relationship (SAR) profiles that led to the identification of potent pyrazole and isoflavone compounds with low micromolar potency against human glycogen synthase 1 (hGYS1). Notably, several of the isoflavones demonstrated cellular efficacy toward suppressing glycogen accumulation. In an alternative effort to screen inhibitors directly against human GS, an activity-based assay was designed using a two-step colorimetric approach. This assay led to the identification of compounds with submicromolar potency to hGYS1 from a chemical library comprised of 10,000 compounds. One of the hit molecules, hexachlorophene, was crystallized bound to the active site of yGsy2. The structure was determined to 3.15 Å. Additional kinetic, mutagenic, and SAR studies validated the binding of hexachlorophene in the catalytic pocket and its non-competitive mode of inhibition. In summary, these two novel assays provided feasible biochemical platforms for large-scale screening of small molecule modulators of GS. The newly-developed, potent analogs possess diverse promising scaffolds for drug development efforts targeting GS activity in GSDs associated with excess glycogen accumulation.2021-07-0

Special Libraries, October 1926

Volume 17, Issue 7https://scholarworks.sjsu.edu/sla_sl_1926/1006/thumbnail.jp

HIKA - August 1942

https://digital.kenyon.edu/hika/1035/thumbnail.jp

Political culture in Belgium

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