From Nano to Macro: Overview of the IEEE Bio Image and Signal Processing Technical Committee

The Bio Image and Signal Processing (BISP) Technical Committee (TC) of the IEEE Signal Processing Society (SPS) promotes activities within the broad technical field of biomedical image and signal processing. Areas of interest include medical and biological imaging, digital pathology, molecular imaging, microscopy, and associated computational imaging, image analysis, and image-guided treatment, alongside physiological signal processing, computational biology, and bioinformatics. BISP has 40 members and covers a wide range of EDICS, including CIS-MI: Medical Imaging, BIO-MIA: Medical Image Analysis, BIO-BI: Biological Imaging, BIO: Biomedical Signal Processing, BIO-BCI: Brain/Human-Computer Interfaces, and BIO-INFR: Bioinformatics. BISP plays a central role in the organization of the IEEE International Symposium on Biomedical Imaging (ISBI) and contributes to the technical sessions at the IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), and the IEEE International Conference on Image Processing (ICIP). In this paper, we provide a brief history of the TC, review the technological and methodological contributions its community delivered, and highlight promising new directions we anticipate

Computational methods for molecular docking

This tutorial was one of eight tutorials selected to be presented at the Third International Conference on Intelligent Systems for Molecular Biology which was held in the United Kingdom from July 16 to 19, 1995. Recently, it has been demonstrated that the knowledge of the three-dimensional structure of the protein can be used to derive new protein ligands with improved binding properties. This tutorial focuses on the following questions: What is its binding affinity toward a particular receptor? What are putative conformations of a ligand at the binding site? What are the similarities of different ligands in terms of their recognition capabilities? Where and in which orientation will a ligand bind to the active site? How is a new putative protein ligand selected? An overview is presented of the algorithms which are presently used to handle and predict protein-ligand interactions and to dock small molecule ligands into proteins