9 research outputs found
DFDL: Discriminative Feature-oriented Dictionary Learning for Histopathological Image Classification
In histopathological image analysis, feature extraction for classification is
a challenging task due to the diversity of histology features suitable for each
problem as well as presence of rich geometrical structure. In this paper, we
propose an automatic feature discovery framework for extracting discriminative
class-specific features and present a low-complexity method for classification
and disease grading in histopathology. Essentially, our Discriminative
Feature-oriented Dictionary Learning (DFDL) method learns class-specific
features which are suitable for representing samples from the same class while
are poorly capable of representing samples from other classes. Experiments on
three challenging real-world image databases: 1) histopathological images of
intraductal breast lesions, 2) mammalian lung images provided by the Animal
Diagnostics Lab (ADL) at Pennsylvania State University, and 3) brain tumor
images from The Cancer Genome Atlas (TCGA) database, show the significance of
DFDL model in a variety problems over state-of-the-art methodsComment: Accepted to IEEE International Symposium on Biomedical Imaging
(ISBI), 201
An Information Theoretic Approach For Feature Selection And Segmentation In Posterior Fossa Tumors
Posterior Fossa (PF) is a type of brain tumor located in or near brain stem and cerebellum. About 55% - 70 % pediatric brain tumors arise in the posterior fossa, compared with only 15% - 20% of adult tumors. For segmenting PF tumors we should have features to study the characteristics of tumors. In literature, different types of texture features such as Fractal Dimension (FD) and Multifractional Brownian Motion (mBm) have been exploited for measuring randomness associated with brain and tumor tissues structures, and the varying appearance of tissues in magnetic resonance images (MRI). For selecting best features techniques such as neural network and boosting methods have been exploited. However, neural network cannot descirbe about the properties of texture features. We explore methods such as information theroetic methods which can perform feature selection based on properties of texture features. The primary contribution of this dissertation is investigating efficacy of different image features such as intensity, fractal texture, and level - set shape in segmentation of PF tumor for pediatric patients. We explore effectiveness of using four different feature selection and three different segmentation techniques respectively to discriminate tumor regions from normal tissue in multimodal brain MRI. Our research suggest that Kullback - Leibler Divergence (KLD) measure for feature ranking and selection and Expectation Maximization (EM) algorithm for feature fusion and tumor segmentation offer the best performance for the patient data in this study. To improve segmentation accuracy, we need to consider abnormalities such as cyst, edema and necrosis which surround tumors. In this work, we exploit features which describe properties of cyst and technique which can be used to segment it. To achieve this goal, we extend the two class KLD techniques to multiclass feature selection techniques, so that we can effectively select features for tumor, cyst and non tumor tissues. We compute segemntation accuracy by computing number of pixels segemented to total number of pixels for the best features. For automated process we integrate the inhomoheneity correction, feature selection using KLD and segmentation in an integrated EM framework. To validate results we have used similarity coefficients for computing the robustness of segmented tumor and cyst