21,909 research outputs found

    Automated system for integration and display of physiological response data

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    The system analysis approach was applied in a study of physiological systems in both 1-g and weightlessness, for short and long term experiments. A whole body, algorithm developed as the first step in the construction of a total body simulation system is described and an advanced biomedical computer system concept including interactive display/command consoles is discussed. The documentation of the design specifications, design and development studies, and user's instructions (which include program listings) for these delivered end-terms; the reports on the results of many research and feasibility studies; and many subcontract reports are cited in the bibliography

    Studies of the effects of gravitational and inertial forces on cardiovascular and respiratory dynamics

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    The current status and application are described of the biplane video roentgen densitometry, videometry and video digitization systems. These techniques were developed, and continue to be developed for studies of the effects of gravitational and inertial forces on cardiovascular and respiratory dynamics in intact animals and man. Progress is reported in the field of lung dynamics and three-dimensional reconstruction of the dynamic thoracic contents from roentgen video images. It is anticipated that these data will provide added insight into the role of shape and internal spatial relationships (which is altered particularly by acceleration and position of the body) of these organs as an indication of their functional status

    Aerospace medicine and biology: A continuing bibliography with indexes

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    This bibliography lists 138 reports, articles, and other documents introduced into the NASA scientific and technical information system in Jun. 1980

    Needs Assessment for a Patient Centered Medical Home Model of Care at the Providence Alaska Cancer Center

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    Presented to the Faculty of the University of Alaska Anchorage in Partial Fulfillment of the Requirements for the Degree of MASTER OF PUBLIC HEALTHIn order to better understand the needs of cancer patients and allocate resources, the Providence Alaska Cancer Center requested a needs assessment for an oncology focused patient centered medical home (PCMH). A PCMH allows for coordinated and comprehensive care through the use of a teamwork model that centers on the primary care physician. The Providence Alaska Cancer Center staff randomly selected the records of 200 cancer patients between 2010 and 2011, using the cancer tumor registry. Data were analyzed to answer four specific questions that addressed the 1) presence of a Primary Care Physician (PCP), 2) number and type of comorbidities, 3) cancer diagnosis and 4) insurance status impacted emergency room utilization. Individuals tended to utilize the emergency room more if they 1) had a PCP, 2a) had three or more comorbidities, 2b) were diagnosed with hyperlipidemia, chronic obstructive pulmonary disease (COPD) or hypertension, 3) were diagnosed with an “other” cancer as opposed to breast, lung or gynecological cancers or 4) had federal insurance. These data in particular show expected trends such as patients who have more medical complications have higher emergency room utilization rates than patients with less complicated medical history and that certain comorbidities (hyperlipidemia, hypertension and chronic obstructive pulmonary disease) may be predictors of emergency room utilization. These trends may allow providers to create more specialized treatment and care plans for patients at greater risk of emergency room utilization.Signature Page / Title Page / Abstract / Table of Contents / List of Figures / List of Tables / List of Appendices / Introduction to Cancer and its Treatment / Introduction to the Patient Centered Medical Home Model / Treatment of Cancer in Alaska / Study Goals, Rationale, Research Questions and Hypotheses / Methods / Sample Demographics and Description / Results and Discussion / Strengths and Limitations / Future Directions / References / Appendice

    Aerospace Medicine and Biology: A continuing bibliography, supplement 191

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    A bibliographical list of 182 reports, articles, and other documents introduced into the NASA scientific and technical information system in February 1979 is presented

    Aerospace medicine and biology: A continuing bibliography with indexes (supplement 359)

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    This bibliography lists 164 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during Jan. 1992. Subject coverage includes: aerospace medicine and physiology, life support systems and man/system technology, protective clothing, exobiology and extraterrestrial life, planetary biology, and flight crew behavior and performance

    Aerospace medicine and biology: A continuing bibliography with indexes, supplement 197, September 1979

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    This bibliography lists 193 reports, articles, and other documents introduced into the NASA scientific and technical information system in August 1979

    Aerospace Medicine and Biology: A continuing bibliography, supplement 216

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    One hundred twenty reports, articles, and other documents introduced into the NASA scientific and technical information system in January 1981 are listed. Topics include: sanitary problems; pharmacology; toxicology; safety and survival; life support systems; exobiology; and personnel factors

    Aerospace Medicine and Biology. A continuing bibliography with indexes

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    This bibliography lists 244 reports, articles, and other documents introduced into the NASA scientific and technical information system in February 1981. Aerospace medicine and aerobiology topics are included. Listings for physiological factors, astronaut performance, control theory, artificial intelligence, and cybernetics are included

    Interleukin-6, age, and corpus callosum integrity.

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    The contribution of inflammation to deleterious aging outcomes is increasingly recognized; however, little is known about the complex relationship between interleukin-6 (IL-6) and brain structure, or how this association might change with increasing age. We examined the association between IL-6, white matter integrity, and cognition in 151 community dwelling older adults, and tested whether age moderated these associations. Blood levels of IL-6 and vascular risk (e.g., homocysteine), as well as health history information, were collected. Processing speed assessments were administered to assess cognitive functioning, and we employed tract-based spatial statistics to examine whole brain white matter and regions of interest. Given the association between inflammation, vascular risk, and corpus callosum (CC) integrity, fractional anisotropy (FA) of the genu, body, and splenium represented our primary dependent variables. Whole brain analysis revealed an inverse association between IL-6 and CC fractional anisotropy. Subsequent ROI linear regression and ridge regression analyses indicated that the magnitude of this effect increased with age; thus, older individuals with higher IL-6 levels displayed lower white matter integrity. Finally, higher IL-6 levels were related to worse processing speed; this association was moderated by age, and was not fully accounted for by CC volume. This study highlights that at older ages, the association between higher IL-6 levels and lower white matter integrity is more pronounced; furthermore, it underscores the important, albeit burgeoning role of inflammatory processes in cognitive aging trajectories
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