3,518 research outputs found
Unsupervised Feature Selection with Adaptive Structure Learning
The problem of feature selection has raised considerable interests in the
past decade. Traditional unsupervised methods select the features which can
faithfully preserve the intrinsic structures of data, where the intrinsic
structures are estimated using all the input features of data. However, the
estimated intrinsic structures are unreliable/inaccurate when the redundant and
noisy features are not removed. Therefore, we face a dilemma here: one need the
true structures of data to identify the informative features, and one need the
informative features to accurately estimate the true structures of data. To
address this, we propose a unified learning framework which performs structure
learning and feature selection simultaneously. The structures are adaptively
learned from the results of feature selection, and the informative features are
reselected to preserve the refined structures of data. By leveraging the
interactions between these two essential tasks, we are able to capture accurate
structures and select more informative features. Experimental results on many
benchmark data sets demonstrate that the proposed method outperforms many state
of the art unsupervised feature selection methods
Pathway-Based Genomics Prediction using Generalized Elastic Net.
We present a novel regularization scheme called The Generalized Elastic Net (GELnet) that incorporates gene pathway information into feature selection. The proposed formulation is applicable to a wide variety of problems in which the interpretation of predictive features using known molecular interactions is desired. The method naturally steers solutions toward sets of mechanistically interlinked genes. Using experiments on synthetic data, we demonstrate that pathway-guided results maintain, and often improve, the accuracy of predictors even in cases where the full gene network is unknown. We apply the method to predict the drug response of breast cancer cell lines. GELnet is able to reveal genetic determinants of sensitivity and resistance for several compounds. In particular, for an EGFR/HER2 inhibitor, it finds a possible trans-differentiation resistance mechanism missed by the corresponding pathway agnostic approach
- …