38,941 research outputs found
Estimation and uncertainty of reversible Markov models
Reversibility is a key concept in Markov models and Master-equation models of
molecular kinetics. The analysis and interpretation of the transition matrix
encoding the kinetic properties of the model relies heavily on the
reversibility property. The estimation of a reversible transition matrix from
simulation data is therefore crucial to the successful application of the
previously developed theory. In this work we discuss methods for the maximum
likelihood estimation of transition matrices from finite simulation data and
present a new algorithm for the estimation if reversibility with respect to a
given stationary vector is desired. We also develop new methods for the
Bayesian posterior inference of reversible transition matrices with and without
given stationary vector taking into account the need for a suitable prior
distribution preserving the meta- stable features of the observed process
during posterior inference. All algorithms here are implemented in the PyEMMA
software - http://pyemma.org - as of version 2.0
Alternating-Direction Line-Relaxation Methods on Multicomputers
We study the multicom.puter performance of a three-dimensional Navier–Stokes solver based on alternating-direction line-relaxation methods. We compare several multicomputer implementations, each of which combines a particular line-relaxation method and a particular distributed block-tridiagonal solver. In our experiments, the problem size was determined by resolution requirements of the application. As a result, the granularity of the computations of our study is finer than is customary in the performance analysis of concurrent block-tridiagonal solvers. Our best results were obtained with a modified half-Gauss–Seidel line-relaxation method implemented by means of a new iterative block-tridiagonal solver that is developed here. Most computations were performed on the Intel Touchstone Delta, but we also used the Intel Paragon XP/S, the Parsytec SC-256, and the Fujitsu S-600 for comparison
Non-Markov stochastic dynamics of real epidemic process of respiratory infections
The study of social networks and especially of the stochastic dynamics of the
diseases spread in human population has recently attracted considerable
attention in statistical physics. In this work we present a new statistical
method of analyzing the spread of epidemic processes of grippe and acute
respiratory track infections (ARTI) by means of the theory of discrete
non-Markov stochastic processes. We use the results of our last theory (Phys.
Rev. E 65, 046107 (2002)) to study statistical memory effects, long - range
correlation and discreteness in real data series, describing the epidemic
dynamics of human ARTI infections and grippe. We have carried out the
comparative analysis of the data of the two infections (grippe and ARTI) in one
of the industrial districts of Kazan, one of the largest cities of Russia. The
experimental data are analyzed by the power spectra of the initial time
correlation function and the memory functions of junior orders, the phase
portraits of the four first dynamic variables, the three first points of the
statistical non-Markov parameter and the locally averaged kinetic and
relaxation parameters. The received results give an opportunity to provide
strict quantitative description of the regular and stochastic components in
epidemic dynamics of social networks taking into account their time
discreteness and effects of statistical memory. They also allow to reveal the
degree of randomness and predictability of the real epidemic process in the
specific social network.Comment: 18 pages, 8figs, 1 table
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