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Global morphogenetic flow is accurately predicted by the spatial distribution of myosin motors.
During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding into specific shapes. While developmental biology has identified key genes and local cellular processes, global coordination of tissue remodeling at the organ scale remains unclear. Here, we combine in toto light-sheet microscopy of the Drosophila embryo with quantitative analysis and physical modeling to relate cellular flow with the patterns of force generation during the gastrulation process. We find that the complex spatio-temporal flow pattern can be predicted from the measured meso-scale myosin density and anisotropy using a simple, effective viscous model of the tissue, achieving close to 90% accuracy with one time dependent and two constant parameters. Our analysis uncovers the importance of a) spatial modulation of myosin distribution on the scale of the embryo and b) the non-locality of its effect due to mechanical interaction of cells, demonstrating the need for the global perspective in the study of morphogenetic flow
Multi-agent decision-making dynamics inspired by honeybees
When choosing between candidate nest sites, a honeybee swarm reliably chooses
the most valuable site and even when faced with the choice between near-equal
value sites, it makes highly efficient decisions. Value-sensitive
decision-making is enabled by a distributed social effort among the honeybees,
and it leads to decision-making dynamics of the swarm that are remarkably
robust to perturbation and adaptive to change. To explore and generalize these
features to other networks, we design distributed multi-agent network dynamics
that exhibit a pitchfork bifurcation, ubiquitous in biological models of
decision-making. Using tools of nonlinear dynamics we show how the designed
agent-based dynamics recover the high performing value-sensitive
decision-making of the honeybees and rigorously connect investigation of
mechanisms of animal group decision-making to systematic, bio-inspired control
of multi-agent network systems. We further present a distributed adaptive
bifurcation control law and prove how it enhances the network decision-making
performance beyond that observed in swarms
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