An Automatic Detection of Brain Tumor using CNN & VGG19

According to the 2019 cancer statistics by WHO, brain tumors are considered the main cause of mortality related to cancer throughout the world and are known as one of the most common forms of cancer both in children as well as adults. Among the most common brain tumors, we have those that begin and tend to remain in the brain, which as meningioma with 34% of presence, another type of tumor is called glioma, arising from the surrounding tissue in the brain, it is part of 30% of all tumors in the brain, however, this glioma represents 80% of malignant tumors, making it the most common tumor common that causes death. However, this scheme depicts how convolutional neural networks using VGG19 model can provide an effective mechanism to detect brain tumors at an early stage using MRI images and can save the lives of mankind. Consequently, this research classified glioma brain tumor images using VGG-19 with HE preprocessing data. The model was tested to get a comparison of accuracy, precision, recall, and f1-score of the two test data, namely the original data and HE data. Based on the results of model testing, we can see in table2  that the original data produced the highest values of accuracy, precision, recall, and F1-score, with values of 97% accuracy, 100% precision, 97% recall, and 98% f1 score. While data using HE preprocessing has an accuracy value of 92%, precision of 100%, recall of 92%, and f1 score of 96%t.

A review on a deep learning perspective in brain cancer classification

AWorld Health Organization (WHO) Feb 2018 report has recently shown that mortality rate due to brain or central nervous system (CNS) cancer is the highest in the Asian continent. It is of critical importance that cancer be detected earlier so that many of these lives can be saved. Cancer grading is an important aspect for targeted therapy. As cancer diagnosis is highly invasive, time consuming and expensive, there is an immediate requirement to develop a non-invasive, cost-effective and efficient tools for brain cancer characterization and grade estimation. Brain scans using magnetic resonance imaging (MRI), computed tomography (CT), as well as other imaging modalities, are fast and safer methods for tumor detection. In this paper, we tried to summarize the pathophysiology of brain cancer, imaging modalities of brain cancer and automatic computer assisted methods for brain cancer characterization in a machine and deep learning paradigm. Another objective of this paper is to find the current issues in existing engineering methods and also project a future paradigm. Further, we have highlighted the relationship between brain cancer and other brain disorders like stroke, Alzheimer’s, Parkinson’s, andWilson’s disease, leukoriaosis, and other neurological disorders in the context of machine learning and the deep learning paradigm

Artificial intelligence (AI) in medicine, current applications and future role with special emphasis on its potential and promise in pathology: Present and future impact, obstacles including costs and acceptance among pathologists, practical and philosophical considerations. A comprehensive review

Background: The role of Artificial intelligence (AI) which is defined as the ability of computers to perform tasks that normally require human intelligence is constantly expanding. Medicine was slow to embrace AI. However, the role of AI in medicine is rapidly expanding and promises to revolutionize patient care in the coming years. In addition, it has the ability to democratize high level medical care and make it accessible to all parts of the world.Main text: Among specialties of medicine, some like radiology were relatively quick to adopt AI whereas others especially pathology (and surgical pathology in particular) are only just beginning to utilize AI. AI promises to play a major role in accurate diagnosis, prognosis and treatment of cancers. In this paper, the general principles of AI are defined first followed by a detailed discussion of its current role in medicine. In the second half of this comprehensive review, the current and future role of AI in surgical pathology is discussed in detail including an account of the practical difficulties involved and the fear of pathologists of being replaced by computer algorithms. A number of recent studies which demonstrate the usefulness of AI in the practice of surgical pathology are highlighted.Conclusion: AI has the potential to transform the practice of surgical pathology by ensuring rapid and accurate results and enabling pathologists to focus on higher level diagnostic and consultative tasks such as integrating molecular, morphologic and clinical information to make accurate diagnosis in difficult cases, determine prognosis objectively and in this way contribute to personalized care

Brain Tumor Classification Using a Combination of Variational Autoencoders and Generative Adversarial Networks

Brain tumors are a pernicious cancer with one of the lowest five-year survival rates. Neurologists often use magnetic resonance imaging (MRI) to diagnose the type of brain tumor. Automated computer-assisted tools can help them speed up the diagnosis process and reduce the burden on the health care systems. Recent advances in deep learning for medical imaging have shown remarkable results, especially in the automatic and instant diagnosis of various cancers. However, we need a large amount of data (images) to train the deep learning models in order to obtain good results. Large public datasets are rare in medicine. This paper proposes a framework based on unsupervised deep generative neural networks to solve this limitation. We combine two generative models in the proposed framework: variational autoencoders (VAEs) and generative adversarial networks (GANs). We swap the encoder–decoder network after initially training it on the training set of available MR images. The output of this swapped network is a noise vector that has information of the image manifold, and the cascaded generative adversarial network samples the input from this informative noise vector instead of random Gaussian noise. The proposed method helps the GAN to avoid mode collapse and generate realistic-looking brain tumor magnetic resonance images. These artificially generated images could solve the limitation of small medical datasets up to a reasonable extent and help the deep learning models perform acceptably. We used the ResNet50 as a classifier, and the artificially generated brain tumor images are used to augment the real and available images during the classifier training. We compared the classification results with several existing studies and state-of-the-art machine learning models. Our proposed methodology noticeably achieved better results. By using brain tumor images generated artificially by our proposed method, the classification average accuracy improved from 72.63% to 96.25%. For the most severe class of brain tumor, glioma, we achieved 0.769, 0.837, 0.833, and 0.80 values for recall, specificity, precision, and F1-score, respectively. The proposed generative model framework could be used to generate medical images in any domain, including PET (positron emission tomography) and MRI scans of various parts of the body, and the results show that it could be a useful clinical tool for medical experts

A review on detecting brain tumors using deep learning and magnetic resonance images

Early detection and treatment in the medical field offer a critical opportunity to survive people. However, the brain has a significant role in human life as it handles most human body activities. Accurate diagnosis of brain tumors dramatically helps speed up the patient's recovery and the cost of treatment. Magnetic resonance imaging (MRI) is a commonly used technique due to the massive progress of artificial intelligence in medicine, machine learning, and recently, deep learning has shown significant results in detecting brain tumors. This review paper is a comprehensive article suitable as a starting point for researchers to demonstrate essential aspects of using deep learning in diagnosing brain tumors. More specifically, it has been restricted to only detecting brain tumors (binary classification as normal or tumor) using MRI datasets in 2020 and 2021. In addition, the paper presents the frequently used datasets, convolutional neural network architectures (standard and designed), and transfer learning techniques. The crucial limitations of applying the deep learning approach, including a lack of datasets, overfitting, and vanishing gradient problems, are also discussed. Finally, alternative solutions for these limitations are obtained

Assessment of artificial intelligence (AI) reporting methodology in glioma MRI studies using the Checklist for AI in Medical Imaging (CLAIM)

Purpose: The Checklist for Artificial Intelligence in Medical Imaging (CLAIM) is a recently released guideline designed for the optimal reporting methodology of artificial intelligence (AI) studies. Gliomas are the most common form of primary malignant brain tumour and numerous outcomes derived from AI algorithms such as grading, survival, treatment-related effects and molecular status have been reported. The aim of the study is to evaluate the AI reporting methodology for outcomes relating to gliomas in magnetic resonance imaging (MRI) using the CLAIM criteria. Methods: A literature search was performed on three databases pertaining to AI augmentation of glioma MRI, published between the start of 2018 and the end of 2021 Results: A total of 4308 articles were identified and 138 articles remained after screening. These articles were categorised into four main AI tasks: grading (n= 44), predicting molecular status (n= 50), predicting survival (n= 25) and distinguishing true tumour progression from treatment-related effects (n= 10). The average CLAIM score was 20/42 (range: 10–31). Studies most consistently reported the scientific background and clinical role of their AI approach. Areas of improvement were identified in the reporting of data collection, data management, ground truth and validation of AI performance. Conclusion: AI may be a means of producing high-accuracy results for certain tasks in glioma MRI; however, there remain issues with reporting quality. AI reporting guidelines may aid in a more reproducible and standardised approach to reporting and will aid in clinical integration

AI-based glioma grading for a trustworthy diagnosis: an analytical pipeline for improved reliability

Glioma is the most common type of tumor in humans originating in the brain. According to the World Health Organization, gliomas can be graded on a four-stage scale, ranging from the most benign to the most malignant. The grading of these tumors from image information is a far from trivial task for radiologists and one in which they could be assisted by machine-learning-based decision support. However, the machine learning analytical pipeline is also fraught with perils stemming from different sources, such as inadvertent data leakage, adequacy of 2D image sampling, or classifier assessment biases. In this paper, we analyze a glioma database sourced from multiple datasets using a simple classifier, aiming to obtain a reliable tumor grading and, on the way, we provide a few guidelines to ensure such reliability. Our results reveal that by focusing on the tumor region of interest and using data augmentation techniques we significantly enhanced the accuracy and confidence in tumor classifications. Evaluation on an independent test set resulted in an AUC-ROC of 0.932 in the discrimination of low-grade gliomas from high-grade gliomas, and an AUC-ROC of 0.893 in the classification of grades 2, 3, and 4. The study also highlights the importance of providing, beyond generic classification performance, measures of how reliable and trustworthy the model’s output is, thus assessing the model’s certainty and robustness.Carla Pitarch is a fellow of Eurecat’s “Vicente López” PhD grant program.Peer ReviewedPostprint (published version

Brain Tumor Classification in MRI Images Using En-CNN

Brain tumors are among the most common diseases of the central nervous system and are harmful. Early diagnosis is essential for patient proper treatment. Radiologists need an automated system to identify brain tumor images successfully. The identification process is often a tedious and error-prone task. Furthermore, brain tumor binary classification is often characterized by malignant and benign because it involves multi-sequence MRI (T1, T2, T1CE, and FLAIR), making radiologist's work quite challenging. Recently, several classification methods based on deep learning are being used to classify brain tumors. Each model's performance is highly dependent on the CNN architecture used. Due to the complexity of the existing CNN architecture, hyperparameter tuning becomes a problem in its application. We propose a CNN method called en-CNN to overcome this problem. This method is based on VGG-16 that consists of seven convolutional networks, four ReLU, and four max-pooling. The proposed method is used to facilitate the hyperparameter tuning. We also proposed a new approach in which the classification of brain tumors is done directly without priorly doing the segmentation process. The new approach consists of the following stages: preprocessing, image augmentation, and applying the en-CNN method. Our new approach is also doing the classification using four MRI sequences of T1, T1CE, T2, and FLAIR. The proposed method delivers accuracy on the MRI multi-sequence BraTS 2018 dataset with an accuracy of 95.5% for T1, 95.5% for T1CE, 94% for T2, and 97% for FLAIR with mini-batch size 128 and epoch 200 using ADAM optimizer. The accuracy was 4% higher than previous research in the same dataset

Explainability of deep neural networks for MRI analysis of brain tumors

Purpose Artificial intelligence (AI), in particular deep neural networks, has achieved remarkable results for medical image analysis in several applications. Yet the lack of explainability of deep neural models is considered the principal restriction before applying these methods in clinical practice. Methods In this study, we propose a NeuroXAI framework for explainable AI of deep learning networks to increase the trust of medical experts. NeuroXAI implements seven state-of-the-art explanation methods providing visualization maps to help make deep learning models transparent. Results NeuroXAI has been applied to two applications of the most widely investigated problems in brain imaging analysis, i.e., image classification and segmentation using magnetic resonance (MR) modality. Visual attention maps of multiple XAI methods have been generated and compared for both applications. Another experiment demonstrated that NeuroXAI can provide information flow visualization on internal layers of a segmentation CNN. Conclusion Due to its open architecture, ease of implementation, and scalability to new XAI methods, NeuroXAI could be utilized to assist radiologists and medical professionals in the detection and diagnosis of brain tumors in the clinical routine of cancer patients. The code of NeuroXAI is publicly accessible at https://github.com/razeineldin/NeuroXAI