17,368 research outputs found
Generic 3D Representation via Pose Estimation and Matching
Though a large body of computer vision research has investigated developing
generic semantic representations, efforts towards developing a similar
representation for 3D has been limited. In this paper, we learn a generic 3D
representation through solving a set of foundational proxy 3D tasks:
object-centric camera pose estimation and wide baseline feature matching. Our
method is based upon the premise that by providing supervision over a set of
carefully selected foundational tasks, generalization to novel tasks and
abstraction capabilities can be achieved. We empirically show that the internal
representation of a multi-task ConvNet trained to solve the above core problems
generalizes to novel 3D tasks (e.g., scene layout estimation, object pose
estimation, surface normal estimation) without the need for fine-tuning and
shows traits of abstraction abilities (e.g., cross-modality pose estimation).
In the context of the core supervised tasks, we demonstrate our representation
achieves state-of-the-art wide baseline feature matching results without
requiring apriori rectification (unlike SIFT and the majority of learned
features). We also show 6DOF camera pose estimation given a pair local image
patches. The accuracy of both supervised tasks come comparable to humans.
Finally, we contribute a large-scale dataset composed of object-centric street
view scenes along with point correspondences and camera pose information, and
conclude with a discussion on the learned representation and open research
questions.Comment: Published in ECCV16. See the project website
http://3drepresentation.stanford.edu/ and dataset website
https://github.com/amir32002/3D_Street_Vie
Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation
Robenacoxib and ketoprofen are acidic nonsteroidal antiâinflammatory drugs (NSAIDs). Both are licensed for once daily administration in the cat, despite having short blood halfâlives. This study reports the pharmacokinetic/pharmacodynamic (PK/PD) modelling of each drug in a feline model of inflammation. Eight cats were enrolled in a randomized, controlled, threeâperiod crossâover study. In each period, sterile inflammation was induced by the injection of carrageenan into a subcutaneously implanted tissue cage, immediately before the subcutaneous injection of robenacoxib (2 mg/kg), ketoprofen (2 mg/kg) or placebo. Blood samples were taken for the determination of drug and serum thromboxane (Tx)B2 concentrations (measuring COXâ1 activity). Tissue cage exudate samples were obtained for drug and prostaglandin (PG)E2 concentrations (measuring COXâ2 activity). Individual animal pharmacokinetic and pharmacodynamic parameters for COXâ1 and COXâ2 inhibition were generated by PK/PD modelling. S(+) ketoprofen clearance scaled by bioavailability (CL/F) was 0.114 L/kg/h (elimination halfâlife = 1.62 h). For robenacoxib, blood CL/F was 0.684 L/kg/h (elimination halfâlife = 1.13 h). Exudate elimination halfâlives were 25.9 and 41.5 h for S(+) ketoprofen and robenacoxib, respectively. Both drugs reduced exudate PGE2 concentration significantly between 6 and 36 h. Ketoprofen significantly suppressed (>97%) serum TxB2 between 4 min and 24 h, whereas suppression was mild and transient with robenacoxib. In vivoIC50COXâ1/IC50COXâ2 ratios were 66.9:1 for robenacoxib and 1:107 for S(+) ketoprofen. The carboxylic acid nature of both drugs may contribute to the prolonged COXâ2 inhibition in exudate, despite short halfâlives in blood
Holographic particle localization under multiple scattering
We introduce a novel framework that incorporates multiple scattering for
large-scale 3D particle-localization using single-shot in-line holography.
Traditional holographic techniques rely on single-scattering models which
become inaccurate under high particle-density. We demonstrate that by
exploiting multiple-scattering, localization is significantly improved. Both
forward and back-scattering are computed by our method under a tractable
recursive framework, in which each recursion estimates the next higher-order
field within the volume. The inverse scattering is presented as a nonlinear
optimization that promotes sparsity, and can be implemented efficiently. We
experimentally reconstruct 100 million object voxels from a single 1-megapixel
hologram. Our work promises utilization of multiple scattering for versatile
large-scale applications
Unwind: Interactive Fish Straightening
The ScanAllFish project is a large-scale effort to scan all the world's
33,100 known species of fishes. It has already generated thousands of
volumetric CT scans of fish species which are available on open access
platforms such as the Open Science Framework. To achieve a scanning rate
required for a project of this magnitude, many specimens are grouped together
into a single tube and scanned all at once. The resulting data contain many
fish which are often bent and twisted to fit into the scanner. Our system,
Unwind, is a novel interactive visualization and processing tool which
extracts, unbends, and untwists volumetric images of fish with minimal user
interaction. Our approach enables scientists to interactively unwarp these
volumes to remove the undesired torque and bending using a piecewise-linear
skeleton extracted by averaging isosurfaces of a harmonic function connecting
the head and tail of each fish. The result is a volumetric dataset of a
individual, straight fish in a canonical pose defined by the marine biologist
expert user. We have developed Unwind in collaboration with a team of marine
biologists: Our system has been deployed in their labs, and is presently being
used for dataset construction, biomechanical analysis, and the generation of
figures for scientific publication
Photometry and polarimetry of the nucleus of comet 2P/Encke
Broadband imaging photometry, and broadband and narrowband linear polarimetry
was measured for the nucleus of 2P/Encke over the phase-angle range 4 - 28 deg.
An analysis of the point spread function of the comet reveals only weak coma
activity, corresponding to a dust production of the order of 0.05 kg/s. The
nucleus displays a color independent photometric phase function of almost
linear slope. The absolute R filter magnitude at zero phase angle is 15.05 +/-
0.05, and corresponds to an equivalent radius for the nucleus of 2.43 +/- 0.06
km (for an adopted albedo of 0.047). The nucleus color V - R is 0.47 +/- 0.07,
suggesting a spectral slope of 11 +/- 8 %/100nm. The phase function of linear
polarimetry in the V and R filters shows a widely color independent linear
increase with phase angle (0.12 +/- 0.02%/deg). We find discrepancies in the
photometric and polarimetric parameters between 2P/Encke and other minor bodies
in the solar system, which may indicate significant differences in the surface
material properties and light-scattering behavior of the bodies.
The linear polarimetric phase function of 2P/Encke presented here is the
first ever measured for a cometary nucleus, and its analysis encourages future
studies of cometary nuclei in order to characterize the light-scattering
behavior of comets on firm empirical grounds and provide suitable input to a
comprehensive modeling of the light scattering by cometary surfaces.Comment: Accepted by A&
A feasible and automatic free tool for T1 and ECV mapping
Purpose: Cardiac magnetic resonance (CMR) is a useful non-invasive tool for characterizing tissues and detecting myocardial fibrosis and edema. Estimation of extracellular volume fraction (ECV) using T1 sequences is emerging as an accurate biomarker in cardiac diseases associated with diffuse fibrosis. In
this study, automatic software for T1 and ECV map generation consisting of an executable file was developed and validated using phantom and human data.
Methods: T1 mapping was performed in phantoms and 30 subjects (22 patients and 8 healthy subjects) on a 1.5T MR scanner using the modified Look-Locker inversion-recovery (MOLLI) sequence prototype before and 15 min after contrast agent administration. T1 maps were generated using a Fast Nonlinear
Least Squares algorithm. Myocardial ECV maps were generated using both pre- and post-contrast T1 image registration and automatic extraction of blood relaxation rates.
Results: Using our software, pre- and post-contrast T1 maps were obtained in phantoms and healthy subjects resulting in a robust and reliable quantification as compared to reference software. Coregistration of pre- and post-contrast images improved the quality of ECV maps. Mean ECV value in healthy subjects was
24.5% ± 2.5%.
Conclusions: This study demonstrated that it is possible to obtain accurate T1 maps and informative ECV maps using our software. Pixel-wise ECV maps obtained with this automatic software made it possible to visualize and evaluate the extent and severity of ECV alterations
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