Face shape analysis in people with epilepsy

Stereophotogrammetry and dense surface modelling are novel techniques that have been used to study face shape in genetic and neurodevelopmental disorders. In people with epilepsy, it has been recognised that the condition may be associated with underlying structural variants or malformations of cortical development in some cases. Here I recruited 869 people with epilepsy or unaffected relatives and control subjects to study face shape. I sought to explore whether face shape and symmetry, using new metrics for each, could help to predict those people with epilepsy who may have potential underlying genetic or structural causes. My reproducibility studies found that stereophotogrammetry and dense surface modelling were susceptible to error from changes in head position or face expression, but not from camera calibration, image acquisition and image landmarking. The next study found that in people with epilepsy, a measurement of atypical face shape, Face Shape Difference (FSD), was significantly increased in those with pathogenic structural variants compared to those without pathogenic structural variants. The FSD value was used to predict the presence of pathogenic structural variants with a sensitivity of 66- 80% and specificity of 65-78%. Body mass index affects face shape in a partly predictable manner. The effect of body mass index differences was controlled for in a further analysis. I then analysed facial asymmetry and showed that it was increased in people with developmental lesions in the brain but not in people with pathogenic structural variants. A final study showed that stereophotogrammetry, dense surface modelling, FSD and reflected FSD could be used to study a single genetic disorder associated with epilepsy, to find previously unrecognised face shape changes. Stereophotogrammetry and dense surface modelling therefore appear to be promising tools to aid both in discovery of underlying causes for epilepsy and in understanding of such causes in terms of facial development

Research Laboratory of Electronics quarterly progress report no. 84

Reports of research in general physics, plasma dynamics, and communication

The Second International Symposium on Tilapia in Aquaculture

Proceedings of the symposium held in 1987 in Bangkok, Thailand, by tilapia scientists to discuss strategies for future research and development in the tilapia industry worldwide. Contains 82 full papers, 17 poster abstracts and author and species indexes. The full papers were presented under 7 sessions: culture systems, management and production; pathology; genetics and reproduction; nutrition, physiology; biology and ecology; and economics and socioeconomics.Tilapia culture, Conferences

Modern Approaches To Quality Control

Rapid advance have been made in the last decade in the quality control procedures and techniques, most of the existing books try to cover specific techniques with all of their details. The aim of this book is to demonstrate quality control processes in a variety of areas, ranging from pharmaceutical and medical fields to construction engineering and data quality. A wide range of techniques and procedures have been covered

Faculty Publications and Creative Works 2004

Faculty Publications & Creative Works is an annual compendium of scholarly and creative activities of University of New Mexico faculty during the noted calendar year. Published by the Office of the Vice President for Research and Economic Development, it serves to illustrate the robust and active intellectual pursuits conducted by the faculty in support of teaching and research at UNM

Psr1p interacts with SUN/sad1p and EB1/mal3p to establish the bipolar spindle

Regular Abstracts - Sunday Poster Presentations: no. 382During mitosis, interpolar microtubules from two spindle pole bodies (SPBs) interdigitate to create an antiparallel microtubule array for accommodating numerous regulatory proteins. Among these proteins, the kinesin-5 cut7p/Eg5 is the key player responsible for sliding apart antiparallel microtubules and thus helps in establishing the bipolar spindle. At the onset of mitosis, two SPBs are adjacent to one another with most microtubules running nearly parallel toward the nuclear envelope, creating an unfavorable microtubule configuration for the kinesin-5 kinesins. Therefore, how the cell organizes the antiparallel microtubule array in the first place at mitotic onset remains enigmatic. Here, we show that a novel protein psrp1p localizes to the SPB and plays a key role in organizing the antiparallel microtubule array. The absence of psr1+ leads to a transient monopolar spindle and massive chromosome loss. Further functional characterization demonstrates that psr1p is recruited to the SPB through interaction with the conserved SUN protein sad1p and that psr1p physically interacts with the conserved microtubule plus tip protein mal3p/EB1. These results suggest a model that psr1p serves as a linking protein between sad1p/SUN and mal3p/EB1 to allow microtubule plus ends to be coupled to the SPBs for organization of an antiparallel microtubule array. Thus, we conclude that psr1p is involved in organizing the antiparallel microtubule array in the first place at mitosis onset by interaction with SUN/sad1p and EB1/mal3p, thereby establishing the bipolar spindle.postprin