10,731 research outputs found
Cell division and migration in a 'genotype' for neural networks
Much research has been dedicated recently to applying genetic algorithms to populations of
neural networks. However, while in real organisms the inherited genotype maps in complex
ways into the resulting phenotype, in most of this research the development process that
creates the individual phenotype is ignored. In this paper we present a model of neural
development which includes cell division and cell migration in addition to axonal growth and
branching. This reflects, in a very simplified way, what happens in the ontogeny of real
organisms. The development process of our artificial organisms shows successive phases of
functional differentiation and specialization. In addition, we find that mutations that affect
different phases of development have very different evolutionary consequences. A single
change in the early stages of cell division/migration can have huge effects on the phenotype
while changes in later stages have usually a less drammatic impact. Sometimes changes that
affect the first developental stages may be retained producing sudden changes in evolutionary
history
The Morphogenesis Of Evolutionary Developmental Biology
The early studies of evolutionary developmental biology (Evo-Devo) come from several sources. Tributaries flowing into Evo-Devo came from such disciplines as embryology, developmental genetics, evolutionary biology, ecology, paleontology, systematics, medical embryology and mathematical modeling. This essay will trace one of the major pathways, that from evolutionary embryology to Evo-Devo and it will show the interactions of this pathway with two other sources of Evo-Devo: ecological developmental biology and medical developmental biology. Together, these three fields are forming a more inclusive evolutionary developmental biology that is revitalizing and providing answers to old and important questions involving the formation of biodiversity on Earth. The phenotype of Evo-Devo is limited by internal constraints on what could be known given the methods and equipment of the time and it has been framed by external factors that include both academic and global politics
Tracing the Biological Roots of Knowledge
The essay is a critical review of three possible approaches in the theory of knowledge while tracing the biological roots of knowledge: empiricist, rationalist and developmentalist approaches.
Piaget's genetic epistemology, a developmentalist approach, is one of the first comprehensive
treatments on the question of tracing biological roots of knowledge. This developmental approach is
currently opposed, without questioning the biological roots of knowledge, by the more popular
rationalist approach, championed by Chomsky. Developmental approaches are generally coherent
with cybernetic models, of which the theory of autopoiesis proposed by Maturana and Varela made
a significant theoretical move in proposing an intimate connection between metabolism and
knowledge. Modular architecture is currently considered more or less an undisputable model for
both biology as well as cognitive science. By suggesting that modulation of modules is possible by
motor coordination, a proposal is made to account for higher forms of conscious cognition within
the four distinguishable layers of the human mind. Towards the end, the problem of life and
cognition is discussed in the context of the evolution of complex cognitive systems, suggesting the
unique access of phylogeny during the ontogeny of human beings as a very special case, and how
the problem cannot be dealt with independent of the evolution of coding systems in nature
Molecular self-organisation in a developmental model for the evolution of large-scale artificial neural networks
We argue that molecular self-organisation during embryonic development allows evolution to perform highly nonlinear combinatorial optimisation. A structured approach to architectural optimisation of large-scale Artificial Neural Networks using this principle is presented. We also present simulation results demonstrating the evolution of an edge detecting retina using the proposed methodology
Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors
Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in aged Apoe−/− mice that artery TLOs (ATLOs) controlled highly territorialized aorta T cell responses. ATLOs promoted T cell recruitment, primed CD4+ T cells, generated CD4+, CD8+, T regulatory (Treg) effector and central memory cells, converted naive CD4+ T cells into induced Treg cells, and presented antigen by an unusual set of dendritic cells and B cells. Meanwhile, vascular smooth muscle cell lymphotoxin β receptors (VSMC-LTβRs) protected against atherosclerosis by maintaining structure, cellularity, and size of ATLOs though VSMC-LTβRs did not affect secondary lymphoid organs: Atherosclerosis was markedly exacerbated in Apoe−/−Ltbr−/− and to a similar extent in aged Apoe−/−Ltbrfl/flTagln-cre mice. These data support the conclusion that the immune system employs ATLOs to organize aorta T cell homeostasis during aging and that VSMC-LTβRs participate in atherosclerosis protection via ATLOs
Developmental Systems Theory as a Process Theory
Griffiths and Russell D. Gray (1994, 1997, 2001) have argued that the fundamental unit of analysis in developmental systems theory should be a process – the life cycle – and not a set of developmental resources and interactions between those resources. The key concepts of developmental systems theory, epigenesis and developmental dynamics, both also suggest a process view of the units of development. This chapter explores in more depth the features of developmental systems theory that favour treating processes as fundamental in biology and examines the continuity between developmental systems theory and ideas about process in the work of several major figures in early 20th century biology, most notable C.H Waddington
The Genotype of the Endosperm and Embryo as It Influences Vivipary in Maize
The development of the maize seed is dependent on the orderly unfolding of events in which each component of the developing caryopsis has a particular role to play. The ultimate control of these events must depend upon numerous genes, which if altered will interfere with normal development. Many mutants of this type have been described, ranging from those which produce relatively slight alteration in the caryopsis to those which prevent practically all development. Among those producing relatively slight changes are mutants which give rise to premature germination. The seeds of these mutants develop normally until late in ontogeny. During the early dough stage the plumule begins to elongate, and the seeds germinate while still attached to the ear. Such mutants have been called viviparous
A Minimal Developmental Model Can Increase Evolvability in Soft Robots
Different subsystems of organisms adapt over many time scales, such as rapid
changes in the nervous system (learning), slower morphological and neurological
change over the lifetime of the organism (postnatal development), and change
over many generations (evolution). Much work has focused on instantiating
learning or evolution in robots, but relatively little on development. Although
many theories have been forwarded as to how development can aid evolution, it
is difficult to isolate each such proposed mechanism. Thus, here we introduce a
minimal yet embodied model of development: the body of the robot changes over
its lifetime, yet growth is not influenced by the environment. We show that
even this simple developmental model confers evolvability because it allows
evolution to sweep over a larger range of body plans than an equivalent
non-developmental system, and subsequent heterochronic mutations 'lock in' this
body plan in more morphologically-static descendants. Future work will involve
gradually complexifying the developmental model to determine when and how such
added complexity increases evolvability
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