4,453 research outputs found

    edge2vec: Representation learning using edge semantics for biomedical knowledge discovery

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    Representation learning provides new and powerful graph analytical approaches and tools for the highly valued data science challenge of mining knowledge graphs. Since previous graph analytical methods have mostly focused on homogeneous graphs, an important current challenge is extending this methodology for richly heterogeneous graphs and knowledge domains. The biomedical sciences are such a domain, reflecting the complexity of biology, with entities such as genes, proteins, drugs, diseases, and phenotypes, and relationships such as gene co-expression, biochemical regulation, and biomolecular inhibition or activation. Therefore, the semantics of edges and nodes are critical for representation learning and knowledge discovery in real world biomedical problems. In this paper, we propose the edge2vec model, which represents graphs considering edge semantics. An edge-type transition matrix is trained by an Expectation-Maximization approach, and a stochastic gradient descent model is employed to learn node embedding on a heterogeneous graph via the trained transition matrix. edge2vec is validated on three biomedical domain tasks: biomedical entity classification, compound-gene bioactivity prediction, and biomedical information retrieval. Results show that by considering edge-types into node embedding learning in heterogeneous graphs, \textbf{edge2vec}\ significantly outperforms state-of-the-art models on all three tasks. We propose this method for its added value relative to existing graph analytical methodology, and in the real world context of biomedical knowledge discovery applicability.Comment: 10 page

    Intelligent Fusion of Structural and Citation-Based Evidence for Text Classification

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    This paper investigates how citation-based information and structural content (e.g., title, abstract) can be combined to improve classification of text documents into predefined categories. We evaluate different measures of similarity, five derived from the citation structure of the collection, and three measures derived from the structural content, and determine how they can be fused to improve classification effectiveness. To discover the best fusion framework, we apply Genetic Programming (GP) techniques. Our empirical experiments using documents from the ACM digital library and the ACM classification scheme show that we can discover similarity functions that work better than any evidence in isolation and whose combined performance through a simple majority voting is comparable to that of Support Vector Machine classifiers
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