Formation of modules in a computational model of embryogeny

An investigation is conducted into the effects of a complex mapping between genotype and phenotype upon a simulated evolutionary process. A model of embryogeny is utilised to grow simple French flag like patterns. The system is shown to display a phenotypic robustness to damage and it is argued that this is a result of a modularity forming within the mapping process which causes a functional grouping of sections of the genotype

Degenerate neutrality creates evolvable fitness landscapes

Understanding how systems can be designed to be evolvable is fundamental to research in optimization, evolution, and complex systems science. Many researchers have thus recognized the importance of evolvability, i.e. the ability to find new variants of higher fitness, in the fields of biological evolution and evolutionary computation. Recent studies by Ciliberti et al (Proc. Nat. Acad. Sci., 2007) and Wagner (Proc. R. Soc. B., 2008) propose a potentially important link between the robustness and the evolvability of a system. In particular, it has been suggested that robustness may actually lead to the emergence of evolvability. Here we study two design principles, redundancy and degeneracy, for achieving robustness and we show that they have a dramatically different impact on the evolvability of the system. In particular, purely redundant systems are found to have very little evolvability while systems with degeneracy, i.e. distributed robustness, can be orders of magnitude more evolvable. These results offer insights into the general principles for achieving evolvability and may prove to be an important step forward in the pursuit of evolvable representations in evolutionary computation

New insights on neutral binary representations for evolutionary optimization

This paper studies a family of redundant binary representations NNg(l, k), which are based on the mathematical formulation of error control codes, in particular, on linear block codes, which are used to add redundancy and neutrality to the representations. The analysis of the properties of uniformity, connectivity, synonymity, locality and topology of the NNg(l, k) representations is presented, as well as the way an (1+1)-ES can be modeled using Markov chains and applied to NK fitness landscapes with adjacent neighborhood.The results show that it is possible to design synonymously redundant representations that allow an increase of the connectivity between phenotypes. For easy problems, synonymously NNg(l, k) representations, with high locality, and where it is not necessary to present high values of connectivity are the most suitable for an efficient evolutionary search. On the contrary, for difficult problems, NNg(l, k) representations with low locality, which present connectivity between intermediate to high and with intermediate values of synonymity are the best ones. These results allow to conclude that NNg(l, k) representations with better performance in NK fitness landscapes with adjacent neighborhood do not exhibit extreme values of any of the properties commonly considered in the literature of evolutionary computation. This conclusion is contrary to what one would expect when taking into account the literature recommendations. This may help understand the current difficulty to formulate redundant representations, which are proven to be successful in evolutionary computation. (C) 2016 Elsevier B.V. All rights reserved

Artificial evolution with Binary Decision Diagrams: a study in evolvability in neutral spaces

This thesis develops a new approach to evolving Binary Decision Diagrams, and uses it to study evolvability issues. For reasons that are not yet fully understood, current approaches to artificial evolution fail to exhibit the evolvability so readily exhibited in nature. To be able to apply evolvability to artificial evolution the field must first understand and characterise it; this will then lead to systems which are much more capable than they are currently. An experimental approach is taken. Carefully crafted, controlled experiments elucidate the mechanisms and properties that facilitate evolvability, focusing on the roles and interplay between neutrality, modularity, gradualism, robustness and diversity. Evolvability is found to emerge under gradual evolution as a biased distribution of functionality within the genotype-phenotype map, which serves to direct phenotypic variation. Neutrality facilitates fitness-conserving exploration, completely alleviating local optima. Population diversity, in conjunction with neutrality, is shown to facilitate the evolution of evolvability. The search is robust, scalable, and insensitive to the absence of initial diversity. The thesis concludes that gradual evolution in a search space that is free of local optima by way of neutrality can be a viable alternative to problematic evolution on multi-modal landscapes

Competent Program Evolution, Doctoral Dissertation, December 2006

Heuristic optimization methods are adaptive when they sample problem solutions based on knowledge of the search space gathered from past sampling. Recently, competent evolutionary optimization methods have been developed that adapt via probabilistic modeling of the search space. However, their effectiveness requires the existence of a compact problem decomposition in terms of prespecified solution parameters. How can we use these techniques to effectively and reliably solve program learning problems, given that program spaces will rarely have compact decompositions? One method is to manually build a problem-specific representation that is more tractable than the general space. But can this process be automated? My thesis is that the properties of programs and program spaces can be leveraged as inductive bias to reduce the burden of manual representation-building, leading to competent program evolution. The central contributions of this dissertation are a synthesis of the requirements for competent program evolution, and the design of a procedure, meta-optimizing semantic evolutionary search (MOSES), that meets these requirements. In support of my thesis, experimental results are provided to analyze and verify the effectiveness of MOSES, demonstrating scalability and real-world applicability

Evolving Graphs by Graph Programming

Graphs are a ubiquitous data structure in computer science and can be used to represent solutions to difficult problems in many distinct domains. This motivates the use of Evolutionary Algorithms to search over graphs and efficiently find approximate solutions. However, existing techniques often represent and manipulate graphs in an ad-hoc manner. In contrast, rule-based graph programming offers a formal mechanism for describing relations over graphs. This thesis proposes the use of rule-based graph programming for representing and implementing genetic operators over graphs. We present the Evolutionary Algorithm Evolving Graphs by Graph Programming and a number of its extensions which are capable of learning stateful and stateless digital circuits, symbolic expressions and Artificial Neural Networks. We demonstrate that rule-based graph programming may be used to implement new and effective constraint-respecting mutation operators and show that these operators may strictly generalise others found in the literature. Through our proposal of Semantic Neutral Drift, we accelerate the search process by building plateaus into the fitness landscape using domain knowledge of equivalence. We also present Horizontal Gene Transfer, a mechanism whereby graphs may be passively recombined without disrupting their fitness. Through rigorous evaluation and analysis of over 20,000 independent executions of Evolutionary Algorithms, we establish numerous benefits of our approach. We find that on many problems, Evolving Graphs by Graph Programming and its variants may significantly outperform other approaches from the literature. Additionally, our empirical results provide further evidence that neutral drift aids the efficiency of evolutionary search

Adaptive evolution of transcription factor binding sites

The regulation of a gene depends on the binding of transcription factors to specific sites located in the regulatory region of the gene. The generation of these binding sites and of cooperativity between them are essential building blocks in the evolution of complex regulatory networks. We study a theoretical model for the sequence evolution of binding sites by point mutations. The approach is based on biophysical models for the binding of transcription factors to DNA. Hence we derive empirically grounded fitness landscapes, which enter a population genetics model including mutations, genetic drift, and selection. We show that the selection for factor binding generically leads to specific correlations between nucleotide frequencies at different positions of a binding site. We demonstrate the possibility of rapid adaptive evolution generating a new binding site for a given transcription factor by point mutations. The evolutionary time required is estimated in terms of the neutral (background) mutation rate, the selection coefficient, and the effective population size. The efficiency of binding site formation is seen to depend on two joint conditions: the binding site motif must be short enough and the promoter region must be long enough. These constraints on promoter architecture are indeed seen in eukaryotic systems. Furthermore, we analyse the adaptive evolution of genetic switches and of signal integration through binding cooperativity between different sites. Experimental tests of this picture involving the statistics of polymorphisms and phylogenies of sites are discussed.Comment: published versio