Automatic detection and classification of leukaemia cells

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Today, there is a substantial number of software and research groups that focus on the development of image processing software to extract useful information from medical images, in order to assist and improve patient diagnosis. The work presented in this thesis is centred on processing of images of blood and bone marrow smears of patients suffering from leukaemia, a common type of cancer. In general, cancer is due to aberrant gene expression, which is caused by either mutations or epigenetic changes in DNA. Poor diet and unhealthy lifestyle may trigger or contribute to these changes, although the underlying mechanism is often unknown. Importantly, many cancer types including leukaemia are curable and patient survival and treatment can be improved, subject to prompt diagnosis. In particular, this study focuses on Acute Myeloid Leukaemia (AML), which can be of eight distinct types (M0 to M7), with the main objective to develop a methodology to automatically detect and classify leukaemia cells into one of the above types. The data was collected from the Department of Haematology, Universiti Sains Malaysia, in Malaysia. Three main methods, namely Cellular Automata, Heuristic Search and classification using Neural Networks are facilitated. In the case of Cellular Automata, an improved method based on the 8-neighbourhood and rules were developed to remove noise from images and estimate the radius of the potential blast cells contained in them. The proposed methodology selects the starting points, corresponding to potential blast cells, for the subsequent seeded heuristic search. The Seeded Heuristic employs a new fitness function for blast cell detection. Furthermore, the WEKA software is utilised for classification of blast cells and hence images, into AML subtypes. As a result accuracy of 97.22% was achieved in the classification of blasts into M3 and other AML subtypes. Finally, these algorithms are integrated into an automated system for image processing. In brief, the research presented in this thesis involves the use of advanced computational techniques for processing and classification of medical images, that is, images of blood samples from patients suffering from leukaemia.The Institute of Higher Education of Malaysia and the Universiti Sains Islam Malaysia (USIM)

The synthesis of artificial neural networks using single string evolutionary techniques.

The research presented in this thesis is concerned with optimising the structure of Artificial Neural Networks. These techniques are based on computer modelling of biological evolution or foetal development. They are known as Evolutionary, Genetic or Embryological methods. Specifically, Embryological techniques are used to grow Artificial Neural Network topologies. The Embryological Algorithm is an alternative to the popular Genetic Algorithm, which is widely used to achieve similar results. The algorithm grows in the sense that the network structure is added to incrementally and thus changes from a simple form to a more complex form. This is unlike the Genetic Algorithm, which causes the structure of the network to evolve in an unstructured or random way. The thesis outlines the following original work: The operation of the Embryological Algorithm is described and compared with the Genetic Algorithm. The results of an exhaustive literature search in the subject area are reported. The growth strategies which may be used to evolve Artificial Neural Network structure are listed. These growth strategies are integrated into an algorithm for network growth. Experimental results obtained from using such a system are described and there is a discussion of the applications of the approach. Consideration is given of the advantages and disadvantages of this technique and suggestions are made for future work in the area. A new learning algorithm based on Taguchi methods is also described. The report concludes that the method of incremental growth is a useful and powerful technique for defining neural network structures and is more efficient than its alternatives. Recommendations are also made with regard to the types of network to which this approach is best suited. Finally, the report contains a discussion of two important aspects of Genetic or Evolutionary techniques related to the above. These are Modular networks (and their synthesis) and the functionality of the network itself

Intrinsically Evolvable Artificial Neural Networks

Dedicated hardware implementations of neural networks promise to provide faster, lower power operation when compared to software implementations executing on processors. Unfortunately, most custom hardware implementations do not support intrinsic training of these networks on-chip. The training is typically done using offline software simulations and the obtained network is synthesized and targeted to the hardware offline. The FPGA design presented here facilitates on-chip intrinsic training of artificial neural networks. Block-based neural networks (BbNN), the type of artificial neural networks implemented here, are grid-based networks neuron blocks. These networks are trained using genetic algorithms to simultaneously optimize the network structure and the internal synaptic parameters. The design supports online structure and parameter updates, and is an intrinsically evolvable BbNN platform supporting functional-level hardware evolution. Functional-level evolvable hardware (EHW) uses evolutionary algorithms to evolve interconnections and internal parameters of functional modules in reconfigurable computing systems such as FPGAs. Functional modules can be any hardware modules such as multipliers, adders, and trigonometric functions. In the implementation presented, the functional module is a neuron block. The designed platform is suitable for applications in dynamic environments, and can be adapted and retrained online. The online training capability has been demonstrated using a case study. A performance characterization model for RC implementations of BbNNs has also been presented

Automata theoretic aspects of temporal behaviour and computability in logical neural networks

Imperial Users onl

Considerations in designing a cybernetic simple 'learning' model; and an overview of the problem of modelling learning

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Learning is viewed as a central feature of living systems and must be manifested in any artifact that claims to exhibit general intelligence. The central aims of the thesis are twofold: (1) - To review and critically assess the empirical and theoretical aspects of learning as have been addressed in a multitude of disciplines, with the aim of extracting fundamental features and elements. (2) - To develop a more systematic approach to the cybernetic modelling of learning than has been achieved hitherto. In pursuit of aim (1) above the following discussions are included: Historical and Philosophical backgrounds; Natural learning, both physiological and psychological aspects; Hierarchies of learning identified in the evolutionary, functional and developmental senses; An extensive section on the general problem of modelling of learning and the formal tools, is included as a link between aims (1) and (2). Following this a systematic and historically oriented study of cybernetic and other related approaches to the problem of modelling of learning is presented. This then leads to the development of a state-of-the-art general purpose experimental cybernetic learning model. The programming and use of this model is also fully described, including an elaborate scheme for the manifestation of simple learning

Digital control networks for virtual creatures

Robot control systems evolved with genetic algorithms traditionally take the form of floating-point neural network models. This thesis proposes that digital control systems, such as quantised neural networks and logical networks, may also be used for the task of robot control. The inspiration for this is the observation that the dynamics of discrete networks may contain cyclic attractors which generate rhythmic behaviour, and that rhythmic behaviour underlies the central pattern generators which drive lowlevel motor activity in the biological world. To investigate this a series of experiments were carried out in a simulated physically realistic 3D world. The performance of evolved controllers was evaluated on two well known control tasks—pole balancing, and locomotion of evolved morphologies. The performance of evolved digital controllers was compared to evolved floating-point neural networks. The results show that the digital implementations are competitive with floating-point designs on both of the benchmark problems. In addition, the first reported evolution from scratch of a biped walker is presented, demonstrating that when all parameters are left open to evolutionary optimisation complex behaviour can result from simple components