Simultaneous control of volumetric light distribution through turbid media using real-time three-dimensional optoacoustic feedback

Focusing light through turbid media presents a highly fascinating challenge in modern biophotonics. The unique capability of optoacoustics for high resolution imaging of light absorption contrast in deep tissues can provide a natural and efficient feedback to control light delivery in scattering medium. While basic feasibility of using optoacoustic readings as a feedback mechanism for wavefront shaping has been recently reported, the suggested approaches may require long acquisition times making them challenging to be translated into realistic tissue environments. In an attempt to significantly accelerate dynamic wavefront shaping capabilities, we present here a feedback-based approach using real-time three-dimensional optoacoustic imaging assisted with genetic-algorithm-based optimization. The new technique offers robust performance in the presence of noisy measurements and can simultaneously control the scattered wave field in an entire volumetric region.Comment: 4 pages, 3 figure

Frequency-splitting Dynamic MRI Reconstruction using Multi-scale 3D Convolutional Sparse Coding and Automatic Parameter Selection

Department of Computer Science and EngineeringIn this thesis, we propose a novel image reconstruction algorithm using multi-scale 3D con- volutional sparse coding and a spectral decomposition technique for highly undersampled dy- namic Magnetic Resonance Imaging (MRI) data. The proposed method recovers high-frequency information using a shared 3D convolution-based dictionary built progressively during the re- construction process in an unsupervised manner, while low-frequency information is recovered using a total variation-based energy minimization method that leverages temporal coherence in dynamic MRI. Additionally, the proposed 3D dictionary is built across three different scales to more efficiently adapt to various feature sizes, and elastic net regularization is employed to promote a better approximation to the sparse input data. Furthermore, the computational com- plexity of each component in our iterative method is analyzed. We also propose an automatic parameter selection technique based on a genetic algorithm to find optimal parameters for our numerical solver which is a variant of the alternating direction method of multipliers (ADMM). We demonstrate the performance of our method by comparing it with state-of-the-art methods on 15 single-coil cardiac, 7 single-coil DCE, and a multi-coil brain MRI datasets at different sampling rates (12.5%, 25% and 50%). The results show that our method significantly outper- forms the other state-of-the-art methods in reconstruction quality with a comparable running time and is resilient to noise.ope

Chemical and biological reactions of solidification of peat using ordinary portland cement (OPC) and coal ashes

Construction over peat area have often posed a challenge to geotechnical engineers. After decades of study on peat stabilisation techniques, there are still no absolute formulation or guideline that have been established to handle this issue. Some researchers have proposed solidification of peat but a few researchers have also discovered that solidified peat seemed to decrease its strength after a certain period of time. Therefore, understanding the chemical and biological reaction behind the peat solidification is vital to understand the limitation of this treatment technique. In this study, all three types of peat; fabric, hemic and sapric were mixed using Mixing 1 and Mixing 2 formulation which consisted of ordinary Portland cement, fly ash and bottom ash at various ratio. The mixtures of peat-binder-filler were subjected to the unconfined compressive strength (UCS) test, bacterial count test and chemical elemental analysis by using XRF, XRD, FTIR and EDS. Two pattern of strength over curing period were observed. Mixing 1 samples showed a steadily increase in strength over curing period until Day 56 while Mixing 2 showed a decrease in strength pattern at Day 28 and Day 56. Samples which increase in strength steadily have less bacterial count and enzymatic activity with increase quantity of crystallites. Samples with lower strength recorded increase in bacterial count and enzymatic activity with less crystallites. Analysis using XRD showed that pargasite (NaCa2[Mg4Al](Si6Al2)O22(OH)2) was formed in the higher strength samples while in the lower strength samples, pargasite was predicted to be converted into monosodium phosphate and Mg(OH)2 as bacterial consortium was re-activated. The Michaelis�Menten coefficient, Km of the bio-chemical reaction in solidified peat was calculated as 303.60. This showed that reaction which happened during solidification work was inefficient. The kinetics for crystallite formation with enzymatic effect is modelled as 135.42 (1/[S] + 0.44605) which means, when pargasite formed is lower, the amount of enzyme secretes is higher

Optimal control of light propagation through multiple-scattering media in the presence of noise

We study the control of coherent light propagation through multiple-scattering media in the presence of measurement noise. In our experiments, we use a two-step optimization procedure to find the optimal incident wavefront. We conclude that the degree of optimal control of coherent light propagation through a multiple-scattering medium is only determined by the number of photoelectrons detected per single speckle spot. The prediction of our model agrees well with the experimental results. Our results offer opportunities for imaging applications through scattering media such as biological tissue in the shot noise limit