65,156 research outputs found
Generic Strategies for Chemical Space Exploration
Computational approaches to exploring "chemical universes", i.e., very large
sets, potentially infinite sets of compounds that can be constructed by a
prescribed collection of reaction mechanisms, in practice suffer from a
combinatorial explosion. It quickly becomes impossible to test, for all pairs
of compounds in a rapidly growing network, whether they can react with each
other. More sophisticated and efficient strategies are therefore required to
construct very large chemical reaction networks.
Undirected labeled graphs and graph rewriting are natural models of chemical
compounds and chemical reactions. Borrowing the idea of partial evaluation from
functional programming, we introduce partial applications of rewrite rules.
Binding substrate to rules increases the number of rules but drastically prunes
the substrate sets to which it might match, resulting in dramatically reduced
resource requirements. At the same time, exploration strategies can be guided,
e.g. based on restrictions on the product molecules to avoid the explicit
enumeration of very unlikely compounds. To this end we introduce here a generic
framework for the specification of exploration strategies in graph-rewriting
systems. Using key examples of complex chemical networks from sugar chemistry
and the realm of metabolic networks we demonstrate the feasibility of a
high-level strategy framework.
The ideas presented here can not only be used for a strategy-based chemical
space exploration that has close correspondence of experimental results, but
are much more general. In particular, the framework can be used to emulate
higher-level transformation models such as illustrated in a small puzzle game
Self-adaptive exploration in evolutionary search
We address a primary question of computational as well as biological research
on evolution: How can an exploration strategy adapt in such a way as to exploit
the information gained about the problem at hand? We first introduce an
integrated formalism of evolutionary search which provides a unified view on
different specific approaches. On this basis we discuss the implications of
indirect modeling (via a ``genotype-phenotype mapping'') on the exploration
strategy. Notions such as modularity, pleiotropy and functional phenotypic
complex are discussed as implications. Then, rigorously reflecting the notion
of self-adaptability, we introduce a new definition that captures
self-adaptability of exploration: different genotypes that map to the same
phenotype may represent (also topologically) different exploration strategies;
self-adaptability requires a variation of exploration strategies along such a
``neutral space''. By this definition, the concept of neutrality becomes a
central concern of this paper. Finally, we present examples of these concepts:
For a specific grammar-type encoding, we observe a large variability of
exploration strategies for a fixed phenotype, and a self-adaptive drift towards
short representations with highly structured exploration strategy that matches
the ``problem's structure''.Comment: 24 pages, 5 figure
Preliminary capture trajectory design for Europa tomography probe
The objective of this work is the preliminary design of a low-DV transfer from an initial elliptical orbit around Jupiter into a final circular orbit around the moon Europa. This type of trajectory represents an excellent opportunity for a low-cost mission to Europa, accomplished through a small orbiter, as in the proposed Europa Tomography Probe mission, a European contribution to NASAâs Europa Multiple-Flyby Mission (or Europa Clipper). The mission strategy is based on the v-infinity leveraging concept, and the use of resonant orbits to exploit multiple gravity-assist from the moon. Possible sequences of resonant orbits are selected with the help of the Tisserand graph. Suitable trajectories are provided by an optimization code based on the parallel running of several differential evolution algorithms. Different solutions are finally compared in terms of propellant consumption and flight time
1991 NASA Life Support Systems Analysis workshop
The 1991 Life Support Systems Analysis Workshop was sponsored by NASA Headquarters' Office of Aeronautics and Space Technology (OAST) to foster communication among NASA, industrial, and academic specialists, and to integrate their inputs and disseminate information to them. The overall objective of systems analysis within the Life Support Technology Program of OAST is to identify, guide the development of, and verify designs which will increase the performance of the life support systems on component, subsystem, and system levels for future human space missions. The specific goals of this workshop were to report on the status of systems analysis capabilities, to integrate the chemical processing industry technologies, and to integrate recommendations for future technology developments related to systems analysis for life support systems. The workshop included technical presentations, discussions, and interactive planning, with time allocated for discussion of both technology status and time-phased technology development recommendations. Key personnel from NASA, industry, and academia delivered inputs and presentations on the status and priorities of current and future systems analysis methods and requirements
Innovation-Based Competition and the Dynamics of Design in Upstream Suppliers
Although the evolution of the design process in car manufacturers and their first-tier suppliers has been studied extensively, the situation is different for upstream industries, usually chemical and steel firms. This article focuses on such upstream suppliers situation based on an interactive research with a major european steel-maker group, Usinor. In its first part, it demonstrate that innovation-based competition is a significant issue for companies situated upstream from end-product manufacturers. The accelerating pace of the (re)design of end products downstream is increasing opportunities for the substitution of raw materials. The importance of this issue is obscured, however, by considerable inertia in the spread of innovations through the sector. Then the article characterises the specificities of implementing an innovative design strategy due to the activity and position of the firm in the industrial chain. The conclusions will make it clear that design models developed for car-manufacturers and first tear suppliers are in many ways unsuitable for this different context. We finally propose 5 principles to evaluate and define a innovation management system in upstream suppliers." innovation";" management";" design organisation";"steel industry"
Intermittent search strategies
This review examines intermittent target search strategies, which combine
phases of slow motion, allowing the searcher to detect the target, and phases
of fast motion during which targets cannot be detected. We first show that
intermittent search strategies are actually widely observed at various scales.
At the macroscopic scale, this is for example the case of animals looking for
food ; at the microscopic scale, intermittent transport patterns are involved
in reaction pathway of DNA binding proteins as well as in intracellular
transport. Second, we introduce generic stochastic models, which show that
intermittent strategies are efficient strategies, which enable to minimize the
search time. This suggests that the intrinsic efficiency of intermittent search
strategies could justify their frequent observation in nature. Last, beyond
these modeling aspects, we propose that intermittent strategies could be used
also in a broader context to design and accelerate search processes.Comment: 72 pages, review articl
Markets for Technology and Their Implications for Corporate Strategy.
Although market transactions for technologies, ideas, knowledge or information are limited by several well-known imperfections, there is evidence that they have become more common than in the past. In this paper we analyze how the presence of markets for technology conditions the technology and corporate strategy of firms. The first and most obvious implication is that markets for technology increase the strategy space: firms can choose to license in the technology instead of developing it in-house or they can choose to license out their technology instead of (or in addition to) investing in the downstream assets needed to manufacture and commercialize the goods. The implications for management include more proactive management of intellectual property, greater attention to external monitoring of technologies, and organizational changes to support technology licensing, joint-ventures and acquisition of external technology. For entrepreneurial startups, markets for technology make a focused business model more attractive. At the industry level, markets for technology may lower barriers to entry and increase competition, with important implications for the firms' broader strategy as well.
- âŠ