379 research outputs found
Artificial Intelligence Applied to Conceptual Design. A Review of Its Use in Architecture
Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG[Abstract] Conceptual architectural design is a complex process that draws on past experience and creativity to generate new designs. The application of artificial intelligence to this process should not be oriented toward finding a solution in a defined search space since the design requirements are not yet well defined in the conceptual stage. Instead, this process should be considered as an exploration of the requirements, as well as of possible solutions to meet those requirements.
This work offers a tour of major research projects that apply artificial intelligence solutions to architectural conceptual design. We examine several approaches, but most of the work focuses on the use of evolutionary computing to perform these tasks. We note a marked increase in the number of papers in recent years, especially since 2015. Most employ evolutionary computing techniques, including cellular automata. Most initial approaches were oriented toward finding innovative and creative forms, while the latest research focuses on optimizing architectural form.This project was supported by the General Directorate of Culture, Education and University Management of Xunta de Galicia (Ref. ED431G/01, ED431D 2017/16), and the Spanish Ministry of Economy and Competitiveness via funding of the unique installation BIOCAI (UNLC08-1E-002, UNLC13-13-3503) and the European Regional Development Funds (FEDER)Xunta de Galicia; ED431G/01Xunta de Galicia; ED431D 2017/1
Protein-Ligand Binding Affinity Directed Multi-Objective Drug Design Based on Fragment Representation Methods
Drug discovery is a challenging process with a vast molecular space to be explored and numerous pharmacological properties to be appropriately considered. Among various drug design protocols, fragment-based drug design is an effective way of constraining the search space and better utilizing biologically active compounds. Motivated by fragment-based drug search for a given protein target and the emergence of artificial intelligence (AI) approaches in this field, this work advances the field of in silico drug design by (1) integrating a graph fragmentation-based deep generative model with a deep evolutionary learning process for large-scale multi-objective molecular optimization, and (2) applying protein-ligand binding affinity scores together with other desired physicochemical properties as objectives. Our experiments show that the proposed method can generate novel molecules with improved property values and binding affinities
The Emergence of Canalization and Evolvability in an Open-Ended, Interactive Evolutionary System
Natural evolution has produced a tremendous diversity of functional
organisms. Many believe an essential component of this process was the
evolution of evolvability, whereby evolution speeds up its ability to innovate
by generating a more adaptive pool of offspring. One hypothesized mechanism for
evolvability is developmental canalization, wherein certain dimensions of
variation become more likely to be traversed and others are prevented from
being explored (e.g. offspring tend to have similarly sized legs, and mutations
affect the length of both legs, not each leg individually). While ubiquitous in
nature, canalization almost never evolves in computational simulations of
evolution. Not only does that deprive us of in silico models in which to study
the evolution of evolvability, but it also raises the question of which
conditions give rise to this form of evolvability. Answering this question
would shed light on why such evolvability emerged naturally and could
accelerate engineering efforts to harness evolution to solve important
engineering challenges. In this paper we reveal a unique system in which
canalization did emerge in computational evolution. We document that genomes
entrench certain dimensions of variation that were frequently explored during
their evolutionary history. The genetic representation of these organisms also
evolved to be highly modular and hierarchical, and we show that these
organizational properties correlate with increased fitness. Interestingly, the
type of computational evolutionary experiment that produced this evolvability
was very different from traditional digital evolution in that there was no
objective, suggesting that open-ended, divergent evolutionary processes may be
necessary for the evolution of evolvability.Comment: SI can be found at: http://www.evolvingai.org/files/SI_0.zi
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