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UMSL Bulletin 2023-2024
The 2023-2024 Bulletin and Course Catalog for the University of Missouri St. Louis.https://irl.umsl.edu/bulletin/1088/thumbnail.jp
A Multi-level Analysis on Implementation of Low-Cost IVF in Sub-Saharan Africa: A Case Study of Uganda.
Introduction: Globally, infertility is a major reproductive disease that affects an estimated 186 million people worldwide. In Sub-Saharan Africa, the burden of infertility is considerably high, affecting one in every four couples of reproductive age. Furthermore, infertility in this context has severe psychosocial, emotional, economic and health consequences. Absence of affordable fertility services in Sub-Saharan Africa has been justified by overpopulation and limited resources, resulting in inequitable access to infertility treatment compared to developed countries. Therefore, low-cost IVF (LCIVF) initiatives have been developed to simplify IVF-related treatment, reduce costs, and improve access to treatment for individuals in low-resource contexts. However, there is a gap between the development of LCIVF initiatives and their implementation in Sub-Saharan Africa. Uganda is the first country in East and Central Africa to undergo implementation of LCIVF initiatives within its public health system at Mulago Women’s Hospital.
Methods: This was an exploratory, qualitative, single, case study conducted at Mulago Women’s Hospital in Kampala, Uganda. The objective of this study was to explore how LCIVF initiatives have been implemented within the public health system of Uganda at the macro-, meso- and micro-level. Primary qualitative data was collected using semi-structured interviews, hospital observations informal conversations, and document review. Using purposive and snowball sampling, a total of twenty-three key informants were interviewed including government officials, clinicians (doctors, nurses, technicians), hospital management, implementers, patient advocacy representatives, private sector practitioners, international organizational representatives, educational institution, and professional medical associations. Sources of secondary data included government and non-government reports, hospital records, organizational briefs, and press outputs. Using a multi-level data analysis approach, this study undertook a hybrid inductive/deductive thematic analysis, with the deductive analysis guided by the Consolidated Framework for Implementation Research (CFIR).
Findings: Factors facilitating implementation included international recognition of infertility as a reproductive disease, strong political advocacy and oversight, patient needs & advocacy, government funding, inter-organizational collaboration, tension to change, competition in the private sector, intervention adaptability & trialability, relative priority, motivation &advocacy of fertility providers and specialist training. While barriers included scarcity of embryologists, intervention complexity, insufficient knowledge, evidence strength & quality of intervention, inadequate leadership engagement & hospital autonomy, poor public knowledge, limited engagement with traditional, cultural, and religious leaders, lack of salary incentives and concerns of revenue loss associated with low-cost options.
Research contributions: This study contributes to knowledge of factors salient to implementation of LCIVF initiatives in a Sub-Saharan context. Effective implementation of these initiatives requires (1) sustained political support and favourable policy & legislation, (2) public sensitization and engagement of traditional, cultural, and religious leaders (3) strengthening local innovation and capacity building of fertility health workers, in particular embryologists (4) sustained implementor leadership engagement and inter-organizational collaboration and (5) proven clinical evidence and utilization of LCIVF initiatives in innovator countries. It also adds to the literature on the applicability of the CFIR framework in explaining factors that influence successful implementation in developing countries and offer opportunities for comparisons across studies
Financial reporting in Europe: Accounting for regulatory and technical challenges
This thesis explores the challenges facing financial reporting in Europe both regulatory and technical in nature. This has involved research into the background of European legislation and conducting face to face semi-structured interviews with senior elite actors from institutions governing the regulatory and technical arrangements of general-purpose financial reporting practice in Europe. European companies are required to disclose information about their financial affairs. The European legislation governing company financial reporting was delegated to the International Accounting Standards Board (IASB) by the EU institutions via Regulation 1606/2002. This thesis argues that European agencies (represented by EFRAG) are caught in a devolved regulatory relationship where the International Accounting Standards Board (IASB) has been able to assume a relatively strong self-regulatory position. This weakens the agency that European legislative institutions have over their own legislation with regards to financial reporting practice. This thesis argues this loss of agency by European institutions over their legislation governing accounting practice is not a fait accompli but is challenged and contested as European institutions seek and need a more co-regulated arrangement. A key argument developed in this thesis is that regulatory arrangements governing accounting practice are evolving in terms of the distribution of responsibilities and control over European financial reporting practice. To understand how the regulatory landscape governing European accounting practice is changing we employ an investigative lens that is grounded in accounting. This investigative lens employs three elements that are regarded in the literature review as significant technical challenges facing accounting practice in Europe. The first of these is retaining or not prudent accounting practice, the second is concerned with the development of non-financial reporting and the third, concerns with installing the public interest not just investor interests in financial disclosures. It is through this investigative lens that this thesis assesses the extent to which regulatory arrangements and agency governing accounting practice in Europe are shifting sands
Adaptation of the human nervous system for self-aware secure mobile and IoT systems
IT systems have been deployed across several domains, such as hospitals and industries, for the management of information and operations. These systems will soon be ubiquitous in every field due to the transition towards the Internet of Things (IoT). The IoT brings devices with sensory functions into IT systems through the process of internetworking. The sensory functions of IoT enable them to generate and process information automatically, either without human contribution or having the least human interaction possible aside from the information and operations management tasks. Security is crucial as it prevents system exploitation. Security has been employed after system implementation, and has rarely been considered as a part of the system. In this dissertation, a novel solution based on a biological approach is presented to embed security as an inalienable part of the system.
The proposed solution, in the form of a prototype of the system, is based on the functions of the human nervous system (HNS) in protecting its host from the impacts caused by external or internal changes. The contributions of this work are the derivation of a new system architecture from HNS functionalities and experiments that prove the implementation feasibility and efficiency of the proposed HNS-based architecture through prototype development and evaluation.
The first contribution of this work is the adaptation of human nervous system functions to propose a new architecture for IT systems security. The major organs and functions of the HNS are investigated and critical areas are identified for the adaptation process. Several individual system components with similar functions to the HNS are created and grouped to form individual subsystems. The relationship between these components is established in a similar way as in the HNS, resulting in a new system architecture that includes security as a core component. The adapted HNS-based system architecture is employed in two the experiments prove its implementation capability, enhancement of security, and overall system operations.
The second contribution is the implementation of the proposed HNS-based security solution in the IoT test-bed. A temperature-monitoring application with an intrusion detection system (IDS) based on the proposed HNS architecture is implemented as part of the test-bed experiment. Contiki OS is used for implementation, and the 6LoWPAN stack is modified during the development process. The application, together with the IDS, has a brain subsystem (BrSS), a spinal cord subsystem (SCSS), and other functions similar to the HNS whose names are changed. The HNS functions are shared between an edge router and resource-constrained devices (RCDs) during implementation. The experiment is evaluated in both test-bed and simulation environments. Zolertia Z1 nodes are used to form a 6LoWPAN network, and an edge router is created by combining Pandaboard and Z1 node for a test-bed setup. Two networks with different numbers of sensor nodes are used as simulation environments in the Cooja simulator.
The third contribution of this dissertation is the implementation of the proposed HNS-based architecture in the mobile platform. In this phase, the Android operating system (OS) is selected for experimentation, and the proposed HNS-based architecture is specifically tailored for Android. A context-based dynamically reconfigurable access control system (CoDRA) is developed based on the principles of the refined HNS architecture. CoDRA is implemented through customization of Android OS and evaluated under real-time usage conditions in test-bed environments.
During the evaluation, the implemented prototype mimicked the nature of the HNS in securing the application under threat with negligible resource requirements and solved the problems in existing approaches by embedding security within the system. Furthermore, the results of the experiments highlighted the retention of HNS functions after refinement for different IT application areas, especially the IoT, due to its resource-constrained nature, and the implementable capability of our proposed HNS architecture.---
IT-järjestelmiä hyödynnetään tiedon ja toimintojen hallinnassa useilla aloilla, kuten sairaaloissa ja teollisuudessa. Siirtyminen kohti esineiden Internetiä (Internet of Things, IoT) tuo tällaiset laitteet yhä kiinteämmäksi osaksi jokapäiväistä elämää. IT-järjestelmiin liitettyjen IoT-laitteiden sensoritoiminnot mahdollistavat tiedon automaattisen havainnoinnin ja käsittelyn osana suurempaa järjestelmää jopa täysin ilman ihmisen myötävaikutusta, poislukien mahdolliset ylläpito- ja hallintatoimenpiteet. Turvallisuus on ratkaisevan tärkeää IT-järjestelmien luvattoman käytön estämiseksi. Valitettavan usein järjestelmäsuunnittelussa turvallisuus ei ole osana ydinsuunnitteluprosessia, vaan otetaan huomioon vasta käyttöönoton jälkeen. Tässä väitöskirjassa esitellään uudenlainen biologiseen lähestymistapaan perustuva ratkaisu, jolla turvallisuus voidaan sisällyttää erottamattomaksi osaksi järjestelmää.
Ehdotettu prototyyppiratkaisu perustuu ihmisen hermoston toimintaan tilanteessa, jossa se suojelee isäntäänsä ulkoisten tai sisäisten muutosten vaikutuksilta. Tämän työn keskeiset tulokset ovat uuden järjestelmäarkkitehtuurin johtaminen ihmisen hermoston toimintaperiaatteesta sekä tällaisen järjestelmän toteutettavuuden ja tehokkuuden arviointi kokeellisen prototyypin kehittämisen ja toiminnan arvioinnin avulla.
Tämän väitöskirjan ensimmäinen kontribuutio on ihmisen hermoston toimintoihin perustuva IT-järjestelmäarkkitehtuuri. Tutkimuksessa arvioidaan ihmisen hermoston toimintaa ja tunnistetaan keskeiset toiminnot ja toiminnallisuudet, jotka mall-innetaan osaksi kehitettävää järjestelmää luomalla näitä vastaavat järjestelmäkomponentit. Nä-istä kootaan toiminnallisuudeltaan hermostoa vastaavat osajärjestelmät, joiden keskinäinen toiminta mallintaa ihmisen hermoston toimintaa. Näin luodaan arkkitehtuuri, jonka keskeisenä komponenttina on turvallisuus. Tämän pohjalta toteutetaan kaksi prototyyppijärjestelmää, joiden avulla arvioidaan arkkitehtuurin toteutuskelpoisuutta, turvallisuutta sekä toimintakykyä.
Toinen kontribuutio on esitetyn hermostopohjaisen turvallisuusratkaisun toteuttaminen IoT-testialustalla. Kehitettyyn arkkitehtuuriin perustuva ja tunkeutumisen estojärjestelmän (intrusion detection system, IDS) sisältävä lämpötilan seurantasovellus toteutetaan käyttäen Contiki OS -käytöjärjestelmää. 6LoWPAN protokollapinoa muokataan tarpeen mukaan kehitysprosessin aikana. IDS:n lisäksi sovellukseen kuuluu aivo-osajärjestelmä (Brain subsystem, BrSS), selkäydinosajärjestelmä (Spinal cord subsystem, SCSS), sekä muita hermoston kaltaisia toimintoja. Nämä toiminnot jaetaan reunareitittimen ja resurssirajoitteisten laitteiden kesken. Tuloksia arvioidaan sekä simulaatioiden että testialustan tulosten perusteella. Testialustaa varten 6LoWPAN verkon toteutukseen valittiin Zolertia Z1 ja reunareititin on toteutettu Pandaboardin ja Z1:n yhdistelmällä. Cooja-simulaattorissa käytettiin mallinnukseen ymp-äristönä kahta erillistä ja erikokoisuta sensoriverkkoa.
Kolmas tämän väitöskirjan kontribuutio on kehitetyn hermostopohjaisen arkkitehtuurin toteuttaminen mobiilialustassa. Toteutuksen alustaksi valitaan Android-käyttöjärjestelmä, ja kehitetty arkkitehtuuri räätälöidään Androidille. Tuloksena on kontekstipohjainen dynaamisesti uudelleen konfiguroitava pääsynvalvontajärjestelmä (context-based dynamically reconfigurable access control system, CoDRA). CoDRA toteutetaan mukauttamalla Androidin käyttöjärjestelmää ja toteutuksen toimivuutta arvioidaan reaaliaikaisissa käyttöolosuhteissa testialustaympäristöissä.
Toteutusta arvioitaessa havaittiin, että kehitetty prototyyppi jäljitteli ihmishermoston toimintaa kohdesovelluksen suojaamisessa, suoriutui tehtävästään vähäisillä resurssivaatimuksilla ja onnistui sisällyttämään turvallisuuden järjestelmän ydintoimintoihin. Tulokset osoittivat, että tämän tyyppinen järjestelmä on toteutettavissa sekä sen, että järjestelmän hermostonkaltainen toiminnallisuus säilyy siirryttäessä sovellusalueelta toiselle, erityisesti resursseiltaan rajoittuneissa IoT-järjestelmissä
Integration of heterogeneous data sources and automated reasoning in healthcare and domotic IoT systems
In recent years, IoT technology has radically transformed many crucial industrial and service sectors such as healthcare. The multi-facets heterogeneity of the devices and the collected information provides important opportunities to develop innovative systems and services. However, the ubiquitous presence of data silos and the poor semantic interoperability in the IoT landscape constitute a significant obstacle in the pursuit of this goal. Moreover, achieving actionable knowledge from the collected data requires IoT information sources to be analysed using appropriate artificial intelligence techniques such as automated reasoning. In this thesis work, Semantic Web technologies have been investigated as an approach to address both the data integration and reasoning aspect in modern IoT systems. In particular, the contributions presented in this thesis are the following: (1) the IoT Fitness Ontology, an OWL ontology that has been developed in order to overcome the issue of data silos and enable semantic interoperability in the IoT fitness domain; (2) a Linked Open Data web portal for collecting and sharing IoT health datasets with the research community; (3) a novel methodology for embedding knowledge in rule-defined IoT smart home scenarios; and (4) a knowledge-based IoT home automation system that supports a seamless integration of heterogeneous devices and data sources
Blockchain Technology: Disruptor or Enhnancer to the Accounting and Auditing Profession
The unique features of blockchain technology (BCT) - peer-to-peer network, distribution ledger, consensus decision-making, transparency, immutability, auditability, and cryptographic security - coupled with the success enjoyed by Bitcoin and other cryptocurrencies have encouraged many to assume that the technology would revolutionise virtually all aspects of business. A growing body of scholarship suggests that BCT would disrupt the accounting and auditing fields by changing accounting practices, disintermediating auditors, and eliminating financial fraud. BCT disrupts audits (Lombard et al.,2021), reduces the role of audit firms (Yermack 2017), undermines accountants' roles with software developers and miners (Fortin & Pimentel 2022); eliminates many management functions, transforms businesses (Tapscott & Tapscott, 2017), facilitates a triple-entry accounting system (Cai, 2021), and prevents fraudulent transactions (Dai, et al., 2017; Rakshit et al., 2022). Despite these speculations, scholars have acknowledged that the application of BCT in the accounting and assurance industry is underexplored and many existing studies are said to lack engagement with practitioners (Dai & Vasarhelyi, 2017; Lombardi et al., 2021; Schmitz & Leoni, 2019).
This study empirically explored whether BCT disrupts or enhances accounting and auditing fields. It also explored the relevance of audit in a BCT environment and the effectiveness of the BCT mechanism for fraud prevention and detection. The study further examined which technical skillsets accountants and auditors require in a BCT environment, and explored the incentives, barriers, and unintended consequences of the adoption of BCT in the accounting and auditing professions. The current COVID-19 environment was also investigated in terms of whether the pandemic has improved BCT adoption or not.
A qualitative exploratory study used semi-structured interviews to engage practitioners from blockchain start-ups, IT experts, financial analysts, accountants, auditors, academics, organisational leaders, consultants, and editors who understood the technology. With the aid of NVIVO qualitative analysis software, the views of 44 participants from 13 countries: New Zealand, Australia, United States, United Kingdom, Canada, Germany, Italy, Ireland, Hong Kong, India, Pakistan, United Arab Emirates, and South Africa were analysed.
The Technological, Organisational, and Environmental (TOE) framework with consequences of innovation context was adopted for this study. This expanded TOE framework was used as the theoretical lens to understand the disruption of BCT and its adoption in the accounting and auditing fields. Four clear patterns emerged. First, BCT is an emerging tool that accountants and auditors use mainly to analyse financial records because technology cannot disintermediate auditors from the financial system. Second, the technology can detect anomalies but cannot prevent financial fraud. Third, BCT has not been adopted by any organisation for financial reporting and accounting purposes, and accountants and auditors do not require new skillsets or an understanding of the BCT programming language to be able to operate in a BCT domain. Fourth, the advent of COVID-19 has not substantially enhanced the adoption of BCT. Additionally, this study highlights the incentives, barriers, and unintended consequences of adopting BCT as financial technology (FinTech). These findings shed light on important questions about BCT disrupting and disintermediating auditors, the extent of adoption in the accounting industry, preventing fraud and anomalies, and underscores the notion that blockchain, as an emerging technology, currently does not appear to be substantially disrupting the accounting and auditing profession.
This study makes methodological, theoretical, and practical contributions. At the methodological level, the study adopted the social constructivist-interpretivism paradigm with an exploratory qualitative method to engage and understand BCT as a disruptive innovation in the accounting industry. The engagement with practitioners from diverse fields, professions, and different countries provides a distinctive and innovative contribution to methodological and practical knowledge. At the theoretical level, the findings contribute to the literature by offering an integrated conceptual TOE framework. The framework offers a reference for practitioners, academics and policymakers seeking to appraise comprehensive factors influencing BCT adoption and its likely unintended consequences. The findings suggest that, at present, no organisations are using BCT for financial reporting and accounting systems. This study contributes to practice by highlighting the differences between initial expectations and practical applications of what BCT can do in the accounting and auditing fields. The study could not find any empirical evidence that BCT will disrupt audits, eliminate the roles of auditors in a financial system, and prevent and detect financial fraud. Also, there was no significant evidence that accountants and auditors required higher-level skillsets and an understanding of BCT programming language to be able to use the technology. Future research should consider the implications of an external audit firm as a node in a BCT network on the internal audit functions. It is equally important to critically examine the relevance of including programming languages or codes in the curriculum of undergraduate accounting students. Future research could also empirically evaluate if a BCT-enabled triple-entry system could prevent financial statements and management fraud
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A microcredentials-based Postgraduate Certificate of Academic Practice (PGCAP)
This paper presents a new certificate that consists entirely of microcredentials: a stackable model. The postgraduate qualification was piloted extensively with staff members at the Open University (OU) and will soon become available for a global audience. The successful completion of study entitles the certificate holder to become a Fellow of the Higher Education Agency in the UK, a highly regarded first stage professional membership and a proxy for teaching excellence. We will present key elements of the programme, key steps in the approval of the qualification and initial feedback from the pilot cohorts
The Development of a Primer Payload with Microparticles for UTI Pathogen Identification Using Polythymidine- Modified LAMP Primers in Droplet LAMP
Nucleic acid amplification tests (NAATs) are among the diagnostic tests with the highest sensitivity and specificity. However, they are more complex to develop than other diagnostic tests such as biochemical tests and lateral flow immunoassay tests. Polymerase chain reaction (PCR) is the gold standard for NAATs. PCR requires thermal cycling to achieve clonal amplification of the target pathogen DNA for diagnosis. Thermal cycling poses a challenge in the development of PCR diagnostics for point-of-care (POC) settings. Loop-mediated isothermal amplification (LAMP) offers an isothermal method for NAATs diagnostics. The advancement of the microfluidics field significantly enhances the development of LAMP diagnostics devices for POC testing. Another challenge with NAATs, is the limitation in the development of multiplex NAATs. Multiplexing however, occupies an important role in the efforts to address the antimicrobial resistance global crisis. Multiplexing will help to provide more thorough and complete diagnostics of infections, and enable doctors to prescribe the most effective antibiotics to the patients. This will help slow the emergence of antibiotic resistant pathogens. We are currently in a period of discovery void, with regards to antibiotics discovery. At this rate, more pathogens are becoming resistant to the antibiotics that we have, faster than we are developing new classes of antibiotics. According to the World Health Organization (WHO) interagency coordination group on AMR report to the secretary general of the United Nations, by 2050, there will be 10 million annual deaths globally, as a result of AMR-related events. There will also be 1 trillion in healthcare costs, and 28 million people will be living in poverty, as a result of the economic impact of uncontrolled AMR. Another area where multiplex diagnostics play a crucial role is infection control in the era of epidemics and pandemics. The increasing prevailing frequency of global pandemics stresses the need for the development of highly accurate and decentralized POC diagnostics. Over the last ten years, there have been more than 30 epidemics and pandemics around the world, including SARS-CoV-2, Monkey pox, India black fungus, Dengue fever, Measles, Zika, Avian influenza, Influenza A and Ebola. With advancing technology and international commerce and relations, we are now more connected than ever. This means that if there are no developments to make molecular tests more accessible at the POC, the future waves of epidemics and pandemics will have faster spread, further reach and more devastating impacts on the lives of the 8 billion people on our planet. We have developed a diagnostic method for executing droplet microfluidics LAMP via a microparticle primer payload mechanism and have demonstrated it with urinary tract infection (UTI) pathogens. With inspiration from overhang PCR and RNA-Seq, we engineered LAMP primers with 5’ polythymidine (PolyT) oligonucleotide (PolyT is placed in the middle of the Forward inner primers and Backward inner primers). The PolyT sequence is recognized by a biotinylated capture oligonucleotide engineered with a polyadenylated (PolyA) polynucleotide on the 3’ end. The streptavidin-coated microparticles functionalized with the PolyA oligonucleotide and PolyT primers, capture their specific target DNA and deliver the cargo into emulsion droplets of LAMP reagents for amplification. This platform provides the ability to multiplex by coding specific pathogen target DNA with different fluorescent signatures of the microparticles
A fault tolerant, peer-to-peer based scheduler for home grids
This thesis presents a fault-tolerant, Peer-to-Peer (P2P) based grid scheduling system for highly dynamic and highly heterogeneous environments, such as home networks, where we can find a variety of devices (laptops, PCs, game consoles, etc.) and networks.
The number of devices found in a house that are capable of processing data has been increasing in the last few years. However, being able to process data does not mean that these devices are powerful, and, in a home environment, there will be a demand for some applications that need significant computing resources, beyond the capabilities of a single domestic device, such as a set top box (examples of such applications are TV recommender systems, image processing and photo indexing systems). A computational grid is a possible solution for this problem, but the constrained environment in the home makes it difficult to use conventional grid scheduling technologies, which demand a powerful infrastructure.
Our solution is based on the distribution of the matchmaking task among providers, leaving the final allocation decision to a central scheduler that can be running on a limited device without a big loss in performance.
We evaluate our solution by simulating different scenarios and configurations against the Opportunistic Load Balance (OLB) scheduling heuristic, which we found to be the best option for home grids from the existing solutions that we analysed. The results have shown that our solution performs similar or better to OLB. Furthermore, our solution also provides fault tolerance, which is not achieved with OLB, and we have formally verified the behaviour our solution against two cases of network partition failure
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